Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora

Drug Metabolism and Pharmacokinetics

Volumn 24, Issue 3, 2009, Pages 201-208

  Toda, Takahiro ^a   Ohi, Kanna ^a   Kudo, Toshiyuki ^a   Yoshida, Tomoyuki ^a   Ikarashi, Nobutomo ^a   Ito, Kiyomi ^a   Sugiyama, Kiyoshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Ciprofloxacin; Cyp3a; Germ free; Intestinal flora; Lithocholic acid; PXR

Indexed keywords

7 ALPHA DEHYDROXYLASE; BACTERIAL DNA; CIPROFLOXACIN; CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A25; FARNESOID X RECEPTOR; GLYCOLITHOCHOLIC ACID; LITHOCHOLIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3; OXYGENASE; PREGNANE X RECEPTOR; TAUROLITHOCHOLIC ACID; TRIAZOLAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTEROIDES FRAGILIS; CLOSTRIDIUM; CLOSTRIDIUM SCINDENS; CLOSTRIDIUM SORDELLII; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; FECES MICROFLORA; GENE EXPRESSION REGULATION; GENE TARGETING; GERMFREE ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; INTESTINE FLORA; LIVER LEVEL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 69949190575     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.24.201     Document Type: Article

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