Intestinal flora induces the expression of Cyp3a in the mouse liver

Xenobiotica

Volumn 39, Issue 4, 2009, Pages 323-334

  Toda, T ^a   Saito, N ^a   Ikarashi, N ^a   Ito, K ^a   Yamamoto, M ^b   Ishige, A ^c   Watanabe, K ^c   Sugiyama, K ^a  

^a HOSHI UNIVERSITY   (Japan)

^b TSUMURA AND CO   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Cyp3a; Germ free; Intestinal flora; Lithocholic acid; Nuclear transcription factors; Pregnane X receptor (PXR)

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A; LITHOCHOLIC ACID; MESSENGER RNA; PREGNANE X RECEPTOR; TRIAZOLAM; CELL RECEPTOR; CYP3A PROTEIN, MOUSE; CYTOCHROME P450; ISOENZYME; PRIMER DNA; STEROID RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; INTESTINE FLORA; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; ANIMAL; BACTERIUM; CHEMISTRY; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE; KINETICS; METABOLISM; MICROBIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; BACTERIA; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GERM-FREE LIFE; INTESTINES; ISOENZYMES; KINETICS; LITHOCHOLIC ACID; LIVER; MALE; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSCRIPTION FACTORS;

EID: 66149103220     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802651984     Document Type: Article

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