Effects of the CYP2B6*6 allele on catalytic properties and inhibition of CYP2B6 in vitro: Implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo

Drug Metabolism and Disposition

Volumn 40, Issue 4, 2012, Pages 717-725

  Xu, Cong ^a   Ogburn, Evan T ^a,c   Guo, Yingying ^b   Desta, Zeruesenay ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c SSCI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYBUPROPION; 8 HYDROXYEFAVIRENZ; AMFEBUTAMONE; CYTOCHROME P450; CYTOCHROME P450 2B6; EFAVIRENZ; UNCLASSIFIED DRUG; VORICONAZOLE; BENZOXAZINE DERIVATIVE; CLOPIDOGREL; CYTOCHROME B5; DRUG DERIVATIVE; ENZYME INHIBITOR; N DEMETHYLASE; PYRIMIDINE DERIVATIVE; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; TICLOPIDINE; TRIAZOLE DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CATALYSIS; CENTRIFUGATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM MASS SPECTROMETRY; ALLELE; BIOTRANSFORMATION; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; BENZOXAZINES; BIOTRANSFORMATION; BUPROPION; CATALYSIS; CYTOCHROMES B5; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; KINETICS; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PYRIMIDINES; SUBSTRATE SPECIFICITY; TICLOPIDINE; TRIAZOLES;

EID: 84863364565     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042416     Document Type: Article

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