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This article reports the complete structure of a GT-C glycosyltransferase, that of the oligosaccharyltransferase ArnT, involved in lipid A glycosylation in bacteria.
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22 Gómez, H., Polyak, I., Thiel, W., Lluch, J.M., Masgrau, L., Retaining glycosyltransferase mechanism studied by QM/MM methods: lipopolysaccharyl-α-1,4-galactosyltransferase C transfers α-galactose via an oxocarbenium ion-like transition state. J Am Chem Soc 134 (2012), 4743–4752.
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27 Sobhanifar, S., Worrall, L.J., Gruninger, R.J., Wasney, G.A., Blaukopf, M., Baumann, L., Lameignere, E., Solomonson, M., Brown, E.D., Withers, S.G., et al. Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase. Proc Natl Acad Sci U S A 112 (2015), E576–E585.
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28 Volkers, G., Worrall, L.J., Kwan, D.H., Yu, C.C., Baumann, L., Lameignere, E., Wasney, G.A., Scott, N.E., Wakarchuk, W., Foster, L.J., et al. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nat Struct Mol Biol 22 (2015), 627–635.
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