The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36022-36028

  Sobhany, Mack ^a   Kakuta, Yoshimitsu ^b   Sugiura, Nobuo ^c   Kimata, Koji ^c   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; C-TERMINAL PEPTIDES; CHONDROITIN; CHONDROITIN SYNTHASE; COORDINATED REACTIONS; DONOR BINDING; ENZYME REACTION; GLUCURONIC ACIDS; GLYCOSYL TRANSFERASE; GLYCOSYLTRANSFERASE ACTIVITY; N-TERMINALS; POLYMERASE ACTIVITIES; STRUCTURAL BASIS; TRANSFER ACTIVITIES; TRANSFER REACTION;

BIOCHEMISTRY; CATALYSIS; GLUCOSE; PEPTIDES;

COORDINATION REACTIONS;

ASPARTYLALANYLTRYPTOPHANYLGLUTAMYLASPARTYLISOLEUCINE; ASPARTYLTRYPTOPHANYLPROLYLSERYLASPARTYLLEUCINE; CHONDROITIN; GLUCOSYLTRANSFERASE; GLUCURONIC ACID; MUTANT PROTEIN; N ACETYLGALACTOSAMINE; POLYPEPTIDE; PROTEIN K4CP; TYROSYLTHREONYLTRYPTOPHANYLGLUTAMYLLYSYLISOLEUCINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; CATALYSIS; CHONDROITIN; ESCHERICHIA COLI; GLYCOSYLATION; HEXOSYLTRANSFERASES; MUTATION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867756236     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.375873     Document Type: Article

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