Substrate-assisted and nucleophilically assisted catalysis in bovine α1,3-galactosyltransferase. Mechanistic implications for retaining glycosyltransferases

Journal of the American Chemical Society

Volumn 135, Issue 18, 2013, Pages 7053-7063

  Gómez, Hansel ^a,b   Lluch, José M ^a,b   Masgrau, Laura ^b  

^a Institut de Biotecnologia I de Biomedicina   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC MECHANISMS; COMPUTATIONAL DATA; DOUBLE-DISPLACEMENT MECHANISMS; GLYCOSYL-ENZYME INTERMEDIATE; GLYCOSYLTRANSFERASES; NUCLEOPHILIC STRENGTH; RETAINING GLYCOSYLTRANSFERASES; SUBSTRATE-ASSISTED CATALYSIS;

BIOCHEMISTRY; CATALYSIS; ENZYMES; MAMMALS; MOLECULES; QUANTUM CHEMISTRY;

SUBSTRATES;

ALPHA 1,3 GALACTOSYLTRANSFERASE; CARBON; GLUTAMINE; GLYCOSYLTRANSFERASE; HYDROGEN; HYDROXYL GROUP; PHOSPHATE; WATER;

ARTICLE; CALCULATION; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; COW; DENSITY FUNCTIONAL THEORY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; GLYCATION; HYDROLYSIS; MOLECULAR MECHANICS; NUCLEOPHILICITY; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; QUANTUM MECHANICS;

ANIMALS; BIOCATALYSIS; CATTLE; GALACTOSYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; SUBSTRATE SPECIFICITY;

EID: 84877299428     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4024447     Document Type: Article

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