Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding

Journal of Biological Chemistry

Volumn 288, Issue 44, 2013, Pages 31963-31970

  Tsutsui, Yuko ^a   Ramakrishnan, Boopathy ^a   Qasba, Pradman K ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC MECHANISMS; CONFORMATIONAL CHANGE; GALACTOSE MOIETIES; HYDROPHOBIC INTERACTIONS; MICHAELIS COMPLEX; PROTEIN MOLECULES; PROTEOGLYCAN SYNTHESIS; SUBSTRATE BINDING;

CATALYSIS; CONFORMATIONS; ENZYMES; HYDROGEN BONDS; HYDROPHOBICITY; MANGANESE; MOLECULES;

SUBSTRATES;

ASPARAGINE; ASPARTIC ACID; BETA 1,4 GALACTOSYLTRANSFERASE 7; DROSOPHILA PROTEIN; GALACTOSE; GALACTOSYLTRANSFERASE; HYDROGEN; MANGANESE; MUTANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GALACTOSE; XYLOSE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DROSOPHILA; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR CLONING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL;

CRYSTAL STRUCTURE; ENZYME MECHANISMS; GLYCOSAMINOGLYCAN; GLYCOSYLTRANSFERASES; PROTEIN STRUCTURE; PROTEOGLYCAN SYNTHESIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GALACTOSYLTRANSFERASES; HUMANS; HYDROGEN BONDING; MUTATION, MISSENSE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE GALACTOSE;

EID: 84887069059     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.509984     Document Type: Article

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