Structure-based evolutionary relationship of glycosyltransferases: a case study of vertebrate β1,4-galactosyltransferase, invertebrate β1,4-N-acetylgalactosaminyltransferase and α-polypeptidyl-N-acetylgalactosaminyltransferase

Current Opinion in Structural Biology

Volumn 20, Issue 5, 2010, Pages 536-542

  Ramakrishnan, Boopathy ^a,b   Qasba, Pradman K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LACTALBUMIN; ALPHA POLYPETIDYL N ACETYLGALACTOSAMINYLTRANSFERASE; BETA 1,4 GALACTOSYLTRANSFERASE; BETA 1,4 N ACETYLGALACTOSAMINYLTRANSFERASE; GLYCOSYLTRANSFERASE; LEUCINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME SYNTHESIS; HUMAN; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; EVOLUTION, MOLECULAR; GLYCOSYLTRANSFERASES; HUMANS; INVERTEBRATES; MOLECULAR SEQUENCE DATA; N-ACETYLGALACTOSAMINYLTRANSFERASES; N-ACETYLLACTOSAMINE SYNTHASE; VERTEBRATES;

INVERTEBRATA; VERTEBRATA;

EID: 78049437295     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2010.07.004     Document Type: Review

References (42)

1. Cantarel B.L., Coutinho P.M., Rancurel C., Bernard T., Lombard V., Henrissat B. The carbohydrate-active EnZymes database (CAZy): an expert resource for glycogenomics. Nucleic Acids Res 2008, 37:D233-238.
2. Kaneko M., Nishihara S., Narimatsu H., Saitou N. The evolutionary history of glycosyltransferase genes. Trends Glycosci Gycotechnol 2001, 13:147-155.
3. Togayachi A., Sato T., Narimatsu H. Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif. Methods Enzymol 2006, 416:91-102.
4. Hennet T. The galactosyltransferase family. Cell Mol Life Sci 2002, 59:1081-1095.
5. Varki A., Lowe J.B. Biological role of glycans. Essentials of Glycobiology 2009, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 75-88. edn 2.
6. Galili U., Macher B.A., Buehler J., Shohet S.B. Human natural anti-α-galactosyl IgG. II. The specific recognition of α(1-3)-linked galactose residues. J Exp Med 1985, 162:573-582.
7. Larsen R.D., Rivera-Marrero C.A., Ernst L.K., Cummings R.D., Lowe J.B. Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:β-d-Gal(1,4)-d-GlcNAc α(1,3)-galactosyltransferase cDNA. J Biol Chem 1990, 2657055-2657061.
8. Varki A. Multiple changes in sialic acid biology during human evolution. Glycoconj J 2009, 26:231-245.
9. Varki A. Uniquely human evolution of sialic acid genetics and biology. Proc Natl Acad Sci U S A 2010, 107:8939-8946.
10. Turcot-Dubois A.L., Le Moullac-Vaidye B., Despiau S., Roubinet F., Bovin N., Le Pendu J., Blancher A. Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals-a birth-and-death evolution model. Glycobiology 2007, 17:516-528.
11. Ashwell G., Morell A.G. Adv Enzymol Relat Areas Mol Biol 1974, 41:99-128.
12. Crocker P.R., Paulson J.C., Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol 2007, 7:255-266.
13. Liu F.T., Rabinovich G.A. Galectins: regulators of acute and chronic inflammation. Ann N Y Acad Sci 2010, 1183:158-182.
14. Vasta G.R. Roles of galectins in infection. Nat Rev Microbiol 2009, 7:424-438.
15. Brew K., Vanaman T.C., Hill R.L. The role of alpha-lactalbumin and the A protein in lactose synthetase: a unique mechanism for the control of a biological reaction. Proc Natl Acad Sci U S A 1968, 59:491-497.
16. Do K.Y., Do S.I., Cummings R.D. Alpha-lactalbumin induces bovine milk beta 1,4-galactosyltransferase to utilize UDP-GalNAc. J Biol Chem 1995, 270:18447-18451.
17. Ramakrishnan B., Qasba P.K. Structure-based design of beta-1,4-galactosyl-transferase (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity. J Biol Chem 2002, 277:20833-20840.
18. Betenbaugh M.J., Tomiya N., Narang S., Hsu J.T., Lee Y.C. Biosynthesis of human-type N-glycans in heterologous systems. Curr Opin Struct Biol 2004, 14601-14606.
19. Haines N., Irvine K.D. Functional analysis of Drosophila β1,4-N-acetlygalactosaminyltransferases. Glycobiology 2004, 15:335-346.
20. Kawar Z.S., van Die I., Cummings R.D. Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc-R β1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. J Biol Chem 2002, 277:34924-34932.
21. Vadaie N., Jarvis D.L. Molecular cloning and functional characterization of a lepidopteran insect β4-N-acetylgalactosaminyltransferase with broad substrate specificity, a functional role in glycoprotein biosynthesis, and a potential functional role in glycolipid biosynthesis. J Biol Chem 2004, 279:33501-33518.
22. Bakker H., Van Tetering A., Agterberg M., Smit A.B., Van den Eijnden D.H., Van Die I. Deletion of two exons from the Lymnaea stagnalis beta1→4-N-acetylglucosaminyltransferase gene elevates the kinetic efficiency of the encoded enzyme for both UDP-sugar donor and acceptor substrates. J Biol Chem 1997, 272:18580-18585.
23. Ramakrishnan B., Qasba P.K. Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates. J Mol Biol 2007, 365:570-576.
24. Qasba P.K., Kumar S. Molecular divergence of lysozymes and alpha-lactalbumin. Crit Rev Biochem Mol Biol 1997, 32:255-306.
25. Brodbeck U., Denton W.L., Tanahashi N., Ebner K.E. The isolation and identification of the B protein of lactose synthetase as alpha-lactalbumin. J Biol Chem 1967, 242:1391-1397.
26. Shaper N.L., Meurer J.A., Joziasse D.H., Chou T.D., Smith E.J., Schnaar R.L., Shaper J.H. The chicken genome contains two functional nonallelic β1,4-galactosyltransferase genes. Chromosomal assignment to syntenic regions tracks fate of the two gene lineages in the human genome. J Biol Chem 1997, 272:31389-31399.
27. Ten Hagen K.G., Fritz T.A., Tabak L.A. All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. Glycobiology 2003, 13:1R-16R.
28. Imberty A., Piller V., Piller F., Breton C. Fold recognition and molecular modeling of a lectin-like domain in UDP-GalNac:polypeptide N-acetylgalactosaminyltransferases. Protein Eng 1997, 10:1353-1356.
29. Kubota T., Shiba T., Sugioka S., Furukawa S., Sawaki H., Kato R., Wakatsuki S., Narimatsu H. Structural basis of carbohydrate transfer activity by human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase (pp-GalNAc-T10). J Mol Biol 2006, 359:708-727.
30. Fritz T.A., Raman J., Tabak L.A. Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. J Biol Chem 2006, 281:8613-8619.
31. Ihara H., Ikeda Y., Toma S., Wang X., Suzuki T., Gu J., Miyoshi E., Tsukihara T., Honke K., Matsumoto A., et al. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. Glycobiology 2007, 17:455-466.
32. Qasba P.K., Ramakrishnan B. Letter to the Glyco-Forum: catalytic domains of glycosyltransferases with 'add-on' domains. Glycobiology 2007, 17:7G-9G.
33. Martinez-Fleites C., He Y., Davies G.J. Structural analyses of enzymes involved in the O-GlcNAc modification. Biochim Biophys Acta 2010, 1800:122-133.
34. Almeida R., Levery S.B., Mandel U., Kresse H., Schwientek T., Bennett E.P., Clausen H. Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. J Biol Chem 1999, 274:26165-26171.
35. Vadaie N., Hulinsky R.S., Jarvis J.D. Identification and characterization of a Drosophila melanogaster ortholog of human beta1,4-galactosyltransferase VII. Glycobiology 2002, 12:589-597.
36. Nakamura Y., Haines N., Chen J., Okajima T., Furukawa K., Urano T., Stanley P., Irvine K.D., Furukawa K. Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. J Biol Chem 2002, 277:46280-46288.
37. Takemae H., Ueda R., Okubo R., Nakato H., Izumi S., Saigo K., Nishihara S. Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster. J Biol Chem 2003, 278:15571-15578.
38. Herman T., Horvitz H.R. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. Proc Natl Acad Sci U S A 1999, 96:974-979.
39. Okajima T., Yoshida K., Kondo T., Furukawa K. Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem 1999, 274:22915-22918.
40. Okajima T., Fukumoto S., Furukawa K., Urano T. Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. J Biol Chem 1999, 274:28841-28844.
41. Seidler D.G., Faiyaz-Ul-Haque M., Hansen U., Yip G.W., Zaidi S.H., Teebi A.S., Kiesel L., Götte M. Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). J Mol Med 2006, 84:583-594.
42. Ramakrishnan B., Qasba P.K. Crystal structure of the catalytic domain of Drosophila β1,4-galactosyltransferase-7. J Biol Chem 2010, 285:15619-15626.