Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target

Structure

Volumn 24, Issue 8, 2016, Pages 1282-1291

  Soares da Costa, Tatiana P ^a   Desbois, Sebastien ^a   Dogovski, Con ^a,b   Gorman, Michael A ^c   Ketaren, Natalia E ^b   Paxman, Jason J ^a,g   Siddiqui, Tanzeela ^b   Zammit, Leanne M ^a   Abbott, Belinda M ^a   Robins Browne, Roy M ^d,e   Parker, Michael W ^b,c   Jameson, Geoffrey B ^f   Hall, Nathan E ^a   Panjikar, Santosh ^g,h   Perugini, Matthew A ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

^f MASSEY UNIVERSITY   (New Zealand)

^g AUSTRALIAN SYNCHROTRON   (Australia)

^h MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; DIHYDRODIPICOLINATE SYNTHASE; LYSINE; SYNTHETASE; UNCLASSIFIED DRUG; 4-HYDROXY-TETRAHYDRODIPICOLINATE SYNTHASE; HYDROLYASE; PROTEIN BINDING; RECOMBINANT PROTEIN;

ALLOSTERISM; AMINO ACID METABOLISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BIOINFORMATICS; CATALYSIS; CHROMATOPHORE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; GRAM STAINING; HYDROGEN BOND; IC50; LEGIONELLA PNEUMOPHILA; MOLECULAR MECHANICS; MOLECULAR WEIGHT; MUTAGENESIS; NEGATIVE FEEDBACK; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SEDIMENTATION RATE; STEREOSPECIFICITY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; ALLOSTERIC SITE; ALPHA HELIX; BETA SHEET; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR MODEL; PHYSIOLOGICAL FEEDBACK; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION; HYDRO-LYASES; KINETICS; LEGIONELLA PNEUMOPHILA; LYSINE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOCOCCUS PNEUMONIAE; SUBSTRATE SPECIFICITY;

EID: 84978966687     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2016.05.019     Document Type: Article

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