How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?

Biochimie

Volumn 92, Issue 7, 2010, Pages 837-845

  Soares da Costa, Tatiana P ^a   Muscroft Taylor, Andrew C ^a   Dobson, Renwick C J ^a,b,c   Devenish, Sean R A ^a   Jameson, Geoffrey B ^d   Gerrard, Juliet A ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MASSEY UNIVERSITY   (New Zealand)

Author keywords

Aldolase; Antibiotic target; Dihydrodipicolinate synthase; Enzyme catalysis

Indexed keywords

ALDEHYDE; ASPARTATE SEMIALDEHYDE; DIHYDRODIPICOLINATE SYNTHASE; LYSINE; PYRUVIC ACID; SYNTHETASE; UNCLASSIFIED DRUG; HYDROLYASE;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ESCHERICHIA COLI; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE; THERMODYNAMICS; WILD TYPE; X RAY CRYSTALLOGRAPHY; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS;

CALORIMETRY; CATALYTIC DOMAIN; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HYDRO-LYASES; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; THERMODYNAMICS;

EID: 77953544755     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.03.004     Document Type: Article

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