From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Dogovski, Con ^a,b   Gorman, Michael A ^c   Ketaren, Natalia E ^b   Praszkier, Judy ^d   Zammit, Leanne M ^a   Mertens, Haydyn D ^e   Bryant, Gary ^f   Yang, Ji ^d   Griffin, Michael D W ^b   Pearce, F Grant ^g   Gerrard, Juliet A ^g,h   Jameson, Geoffrey B ⁱ   Parker, Michael W ^b,c   Robins Browne, Roy M ^d   Perugini, Matthew A ^a,b  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e AUSTRALIAN SYNCHROTRON   (Australia)

^f RMIT UNIVERSITY   (Australia)

^g UNIVERSITY OF CANTERBURY   (New Zealand)

^h CALLAGHAN INNOVATION   (New Zealand)

ⁱ MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDRODIPICOLINATE SYNTHASE; DIPICOLINIC ACID; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DENSITY; CELL SIZE; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DAPA GENE; DHDPS GENE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME DENATURATION; ENZYME MECHANISM; ENZYME STABILITY; ESCHERICHIA COLI; GENE; GENE INACTIVATION; HYDRODYNAMICS; NONHUMAN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; ESCHERICHIA COLI; GENE KNOCKDOWN TECHNIQUES; HYDRO-LYASES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PNEUMONIAE;

EID: 84892534088     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083419     Document Type: Article

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