Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin- resistant Staphylococcus aureus

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 64, Issue 7, 2008, Pages 659-661

  Burgess, Benjamin R ^a,b   Dobson, Renwick C J ^a,b   Dogovski, Con ^a,b   Jameson, Geoffrey B ^c   Parker, Michael W ^a,b,d   Perugini, Matthew A ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MASSEY UNIVERSITY   (New Zealand)

^d ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Antibiotic resistance; Antibiotics; Dihydrodipicolinate synthase; Drug discovery; Lysine biosynthesis; Staphylococcus aureus

Indexed keywords

BACTERIAL PROTEIN; DIHYDRODIPICOLINATE SYNTHASE; HYDROLYASE; MACROGOL DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECT; ENZYMOLOGY; ISOLATION AND PURIFICATION; PATHOGENICITY; PENICILLIN RESISTANCE; STAPHYLOCOCCUS AUREUS; X RAY DIFFRACTION;

BACTERIAL PROTEINS; CRYSTALLIZATION; HYDRO-LYASES; METHICILLIN RESISTANCE; MICROSCOPY, ATOMIC FORCE; POLYETHYLENE GLYCOLS; STAPHYLOCOCCUS AUREUS; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 46949085899     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309108016746     Document Type: Article

References (32)

1. Barnes, I. J., Bondi, A. & Moat, A. G. (1969). J. Bacteriol. 99, 169-174.
2. Blagova, E., Levdikov, V., Milioti, N., Fogg, M. J., Kalliomaa, A. K., Brannigan, J. A., Wilson, K. S. & Wilkinson, A. J. (2006). Proteins, 62, 297-301.
3. Blickling, S., Beisel, H., Bozic, D., Knablein, J., Laber, B. & Huber, R. (1998). J. Mol. Biol. 274, 608-621.
4. Blickling, S., Renner, C., Laber, B., Pohlenz, H.-D., Holak, T. A. & Huber, R. (1997). Biochemistry, 36, 24-33.
5. Cohen, A. E., Ellis, P. J., Miller, M. D., Deacon, A. M. & Phizackerley, R. P. (2002). J. Appl. Cryst. 35, 720-726.
6. Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.
7. Dereppe, C., Bold, G., Ghisalba, O., Ebert, E. & Schar, H. P. (1992). Plant Physiol. 98, 813-821.
8. Dobson, R. C. J., Devenish, S. R. A., Turner, L. A., Clifford, V. R., Pearce, F. G., Jameson, G. B. & Gerrard, J. A. (2005). Biochemistry, 44, 13007-13013.
9. Dobson, R. C. J., Gerrard, J. A. & Pearce, F. G. (2004). Biochem. J. 377, 757-762.
10. Dobson, R. C. J., Griffin, M. D. W., Jameson, G. B. & Gerrard, J. A. (2005). Acta Cryst. D61, 1116-1124.
11. Dobson, R. C. J., Griffin, M., Roberts, S. J. & Gerrard, J. A. (2004). Biochimie, 86, 311-315.
12. Dobson, R. C. J., Valega° rd, K. & Gerrard, J. A. (2004). J. Mol. Biol. 338, 329-339.
13. Evans, G. & Pettifer, R. F. (2001). J. Appl. Cryst. 34, 82-86.
14. Frisch, D. A., Gengenbach, B. G., Tommey, A. M., Sellner, J. M., Somers, D. A. & Myers, D. E. (1991). Plant Physiol. 96, 444-452.
15. Ghislain, M., Frankard, V. & Jacobs, M. (1990). Planta, 180, 480-486.
16. Griffin, M. D. W., Dobson, R. C. J., Pearce, F. G., Antonio, L., Whitten, A. E., Liew, C. K., Mackay, J. P., Trewhella, J., Jameson, G. B., Perugini, M. A. & Gerrard, J. A. (2008). In the press.
17. Hutton, C. A., Perugini, M. A. & Gerrard, J. A. (2007). Mol. Biosyst. 3, 458-465.
18. Hutton, C. A., Southwood, T. J. & Turner, J. J. (2003). Mini Rev. Med. Chem. 3, 115-127.
19. Kefala, G., Evans, G. L., Griffin, M. D. W., Devenish, S. R. A., Pearce, F. G., Perugini, M. A., Gerrard, J. A., Weiss, M. S. & Dobson, R. C. J. (2008). Biochem. J. 411, 351-360.
20. Kumpaisal, R., Hashimoto, T. & Yamada, Y. (1989). Agric. Biol. Chem. 53, 355-359.
21. Laber, B., Gomis-Rüth, F.-X., Româo, M. J. & Huber, R. (1992). Biochem. J. 288, 691-695.
22. Leslie, A. G. W. (1992). Jnt CCP4/ESF-EACBM Newsl. Protein Crystallogr. 26.
23. McPhillips, T. M., McPhillips, S. E., Chiu, H.-J., Cohen, A. E., Deacon, A. M., Ellis, P. J., Garman, E., Gonzalez, A., Sauter, N. K., Phizackerley, R. P., Soltis, S. M. & Kuhn, P. (2002). J. Synchrotron Rad. 9, 401-406.
24. Matthews, B. F. & Widholm, J. M. (1978). Planta, 141, 315-321.
25. Matthews, B. W. (1968). J. Mol. Biol. 33, 491-497.
26. Mirwaldt, C., Korndorfer, I. & Huber, R. (1995). J. Mol. Biol. 246, 227-239.
27. Mitsakos, V., Dobson, R. C. J., Pearce, F. G., Devenish, S. R., Evans, G., Burgess, B. R., Perugini, M. A., Gerrard, J. A. & Hutton, C. A. (2008). Bioorg. Med. Chem. Lett. 18, 842-844.
28. Newman, J., Egan, D., Walter, T. S., Meged, R., Berry, I., Ben Jelloul, M., Sussman, J. L., Stuart, D. I. & Perrakis, A. (2005). Acta Cryst. D61, 1426-1431.
29. Pearce, F. G., Perugini, M. A., McKerchar, H. J. & Gerrard, J. A. (2006). Biochem. J. 400, 359-366.
30. Stahly, D. P. (1969). Biochim. Biophys. Acta, 191, 439-451.
31. Wallsgrove, R. M. & Mazelis, M. (1981). Phytochemistry, 20, 2651-2655.
32. Yugari, Y. & Gilvarg, C. (1965). J. Biol. Chem. 240, 4710-4716.