Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5188-5195

  Voss, Jarrod E ^a   Scally, Stephen W ^a   Taylor, Nicole L ^a   Atkinson, Sarah C ^a   Griffin, Michael D W ^a   Hutton, Craig A ^a   Parker, Michael W ^a,b   Alderton, Malcolm R ^c   Gerrard, Juliet A ^d   Dobson, Renwick C J ^a   Dogovski, Con ^a   Perugini, Matthew A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^d UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACHILLES HEEL; ANALYTICAL ULTRACENTRIFUGATION; ANTHRACIS; ANTIMICROBIAL TARGETS; BACILLUS ANTHRACIS; BIOWARFARES; CD SPECTROSCOPY; DIMER DISSOCIATION; DRUG TARGETS; HIGH RESOLUTION; NEW MECHANISMS; PYRUVATES; SPORE-FORMING BACTERIA; STRUCTURE-BASED DRUG DESIGN; SURFACE AREA; SYNTHASES; TETRAMERIZATION; TETRAMERS; WILD TYPES;

AMINO ACIDS; BACTERIA; BACTERIOLOGY; BARIUM; CENTRIFUGATION; DISSOCIATION; ENZYMES; MACHINE DESIGN; STABILIZATION; SUBSTRATES; TARGETS;

CRYSTAL STRUCTURE;

DIAMINOPIMELIC ACID; DIHYDRODIPICOLINATE SYNTHASE; DIMER; ENZYME; LYSINE; MUTANT PROTEIN; PYRUVIC ACID; TETRAMER; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; HYDROLYASE;

ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; CATALYSIS; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME SUBSTRATE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; THERMOSTABILITY; ULTRACENTRIFUGATION; AMINO ACID SUBSTITUTION; BIOLOGICAL WARFARE AGENT; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

AMINO ACID SUBSTITUTION; ANTHRAX; ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; BACTERIAL PROTEINS; BIOLOGICAL WARFARE AGENTS; DIAMINOPIMELIC ACID; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; LYSINE; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY; PYRUVIC ACID;

EID: 77949314517     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038166     Document Type: Article

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