Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 842-844

  Mitsakos, Voula ^a,b   Dobson, Renwick C J ^a,b,c   Pearce, F Grant ^c   Devenish, Sean R ^c   Evans, Genevieve L ^c   Burgess, Benjamin R ^a,b   Perugini, Matthew A ^a,b   Gerrard, Juliet A ^c   Hutton, Craig A ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Antibacterials; DHDPS; Dihydrodipicolinate synthase; N Acetylneuraminate lyase; NAL; Species specificity

Indexed keywords

ANTIINFECTIVE AGENT; CHELIDAMIC ACID; DIHYDRODIPICOLINATE SYNTHASE; DIHYDRODIPICOLINATE SYNTHASE INHIBITOR; ENZYME INHIBITOR; LYASE; LYASE INHIBITOR; LYSINE; N ACETYLNEURAMINATE LYASE; N ACETYLNEURAMINIC ACID; PICOLINIC ACID; SULFONE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CATALYSIS; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SPECIES DIFFERENCE;

BACILLUS ANTHRACIS; ENZYME INHIBITORS; HYDRO-LYASES; MYCOBACTERIUM TUBERCULOSIS; SPECIES SPECIFICITY; STAPHYLOCOCCUS AUREUS;

BACILLUS ANTHRACIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM TUBERCULOSIS;

EID: 38149068994     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.026     Document Type: Article

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