Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

Life Sciences

Volumn 92, Issue 4-5, 2013, Pages 298-304

  Sripetchwandee, Jirapas ^a   Sanit, Jantira ^a   Chattipakorn, Nipon ^a   Chattipakorn, Siriporn C ^a  

^a CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Brain mitochondria; Iron dyshomeostasis; Keywords; Mitochondrial calcium uniporter (MCU); Mitochondrial membrane potential; Mitochondrial swelling; Reactive oxygen species (ROS)

Indexed keywords

CALCIUM CHANNEL; DEFEROXAMINE; IRON; MITOCHONDRIAL CALCIUM UNIPORTER; REACTIVE OXYGEN METABOLITE; RUTHENIUM 360; RUTHENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BRAIN MITOCHONDRION; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; INCUBATION TIME; IRON OVERLOAD; MALE; MITOCHONDRION SWELLING; NONHUMAN; RAT;

ANIMALS; BRAIN; CALCIUM CHANNELS; CITRATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRIC COMPOUNDS; FERROUS COMPOUNDS; IRON CHELATING AGENTS; IRON OVERLOAD; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL SWELLING; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RUTHENIUM COMPOUNDS; TIME FACTORS;

RATTUS NORVEGICUS;

EID: 84873713188     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.01.004     Document Type: Article

References (41)

1. M.A. Aon, S. Cortassa, E. Marban, and B. O'Rourke Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes J Biol Chem 278 2003 44735 44744
2. E.E. Benarroch Brain iron homeostasis and neurodegenerative disease Neurology 72 2009 1436 1440
3. M.O. Bostanci, O. Bas, and F. Bagirici Alpha-tocopherol decreases iron-induced hippocampal and nigral neuron loss Cell Mol Neurobiol 30 2011 389 394
4. N.R. Brady, A. Hamacher-Brady, H.V. Westerhoff, and R.A. Gottlieb A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria Antioxid Redox Signal 8 2006 1651 1665
5. Z.I. Cabantchik, H. Glickstein, P. Milgram, and W. Breuer A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells Anal Biochem 233 1996 221 227
6. B. Chelli, A. Falleni, F. Salvetti, V. Gremigni, A. Lucacchini, and C. Martini Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue Biochem Pharmacol 61 2001 695 705
7. J.R. Connor, and S.L. Menzies Relationship of iron to oligodendrocytes and myelination Glia 17 1996 83 93
8. D. De Stefani, A. Raffaello, E. Teardo, I. Szabo, and R. Rizzuto A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter Nature 476 2010 336 340
9. L.L. Dunn, Y.S. Rahmanto, and D.R. Richardson Iron uptake and metabolism in the new millennium Trends Cell Biol 17 2007 93 100
10. D.L. Garner, and C.A. Thomas Organelle-specific probe JC-1 identifies membrane potential differences in the mitochondrial function of bovine sperm Mol Reprod Dev 53 1999 222 229
11. G. Gille, and H. Reichmann Iron-dependent functions of mitochondria - relation to neurodegeneration J Neural Transm 118 2010 349 359
12. H.H. Hoepken, T. Korten, S.R. Robinson, and R. Dringen Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate J Neurochem 88 2004 1194 1202
13. Y. Ke, and Z. Ming Qian Iron misregulation in the brain: a primary cause of neurodegenerative disorders Lancet Neurol 2 2003 246 253
14. B. Kulawiak, A.P. Kudin, A. Szewczyk, and W.S. Kunz BK channel openers inhibit ROS production of isolated rat brain mitochondria Exp Neurol 212 2008 543 547
15. S. Kumfu, S. Chattipakorn, S. Srichairatanakool, J. Settakorn, S. Fucharoen, and N. Chattipakorn T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice Eur J Haematol 86 2011 156 166
16. Y.E. Kushnareva, S.E. Wiley, M.W. Ward, A.Y. Andreyev, and A.N. Murphy Excitotoxic injury to mitochondria isolated from cultured neurons J Biol Chem 280 2005 28894 28902
17. D.J. Lehmann, M. Worwood, R. Ellis, V.L. Wimhurst, A.T. Merryweather-Clarke, and D.R. Warden Iron genes, iron load and risk of Alzheimer's disease J Med Genet 43 2006 e52
18. L.P. Liang, S.G. Jarrett, and M. Patel Chelation of mitochondrial iron prevents seizure-induced mitochondrial dysfunction and neuronal injury J Neurosci 28 2008 11550 11556
19. J. Lifshitz, H. Friberg, R.W. Neumar, R. Raghupathi, F.A. Welsh, and P. Janmey Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus J Cereb Blood Flow Metab 23 2003 219 231
20. 2 + channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 Nat Med 13 2007 448 454
21. Z. Lv, H. Jiang, H. Xu, N. Song, and J. Xie Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease J Neural Transm 118 2010 361 369
22. C.J. Murphy, and G.Y. Oudit Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment J Card Fail 16 2010 888 900
23. E. Novalija, L.G. Kevin, J.T. Eells, M.M. Henry, and D.F. Stowe Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism Anesthesiology 98 2003 1155 1163
24. S. Palee, P. Weerateerangkul, S. Surinkeaw, S. Chattipakorn, and N. Chattipakorn Effect of rosiglitazone on cardiac electrophysiology, infarct size and mitochondrial function in ischaemia and reperfusion of swine and rat heart Exp Physiol 96 2011 778 789
25. I. Pelizzoni, R. Macco, M.F. Morini, D. Zacchetti, F. Grohovaz, and F. Codazzi Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity Aging Cell 10 2011 172 183
26. M.G. Perrelli, P. Pagliaro, and C. Penna Ischemia/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species World J Cardiol 3 2011 186 200
27. V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, and F. Di Lisa The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ J Biol Chem 276 2001 12030 12034
28. N. Pipatpiboon, W. Pratchayasakul, N. Chattipakorn, and S.C. Chattipakorn PPARgamma agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets Endocrinology 153 2012 329 338
29. P.H. Reddy, and T.P. Reddy Mitochondria as a therapeutic target for aging and neurodegenerative diseases Curr Alzheimer Res 2011 393 409
30. 2 + uptake during simulated ischemia does not affect permeability transition pore opening upon simulated reperfusion Cardiovasc Res 71 2006 715 724
31. S. Thummasorn, S. Kumfu, S. Chattipakorn, and N. Chattipakorn Granulocyte-colony stimulating factor attenuates mitochondrial dysfunction induced by oxidative stress in cardiac mitochondria Mitochondrion 11 2011 457 466
32. V. Tong, X.W. Teng, T.K. Chang, and F.S. Abbott Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes Toxicol Sci 86 2005 436 443
33. G.T. Vatassery, E.G. DeMaster, J.C. Lai, W.E. Smith, and H.T. Quach Iron uncouples oxidative phosphorylation in brain mitochondria isolated from vitamin E-deficient rats Biochim Biophys Acta 1688 2004 265 273
34. J.M. Walker The bicinchoninic acid (BCA) assay for protein quantitation Methods Mol Biol 32 1994 5 8
35. G. Weiss, G. Werner-Felmayer, E.R. Werner, K. Grunewald, H. Wachter, and M.W. Hentze Iron regulates nitric oxide synthase activity by controlling nuclear transcription J Exp Med 180 1994 969 976
36. C. Yarana, J. Sanit, N. Chattipakorn, and S. Chattipakorn Synaptic and nonsynaptic mitochondria demonstrate a different degree of calcium-induced mitochondrial dysfunction Life Sci 90 2012 808 814
37. C. Yarana, J. Sripetchwandee, J. Sanit, S. Chattipakorn, and N. Chattipakorn Calcium-induced cardiac mitochondrial dysfunction is predominantly mediated by cyclosporine A-dependent mitochondrial permeability transition pore Arch Med Res 43 2012 333 338
38. M.B. Youdim, and A.R. Green Iron deficiency and neurotransmitter synthesis and function Proc Nutr Soc 37 1978 173 179
39. S.Z. Zhang, Q. Gao, C.M. Cao, I.C. Bruce, and Q. Xia Involvement of the mitochondrial calcium uniporter in cardioprotection by ischemic preconditioning Life Sci 78 2006 738 745
40. L. Zhou, M.A. Aon, T. Almas, S. Cortassa, R.L. Winslow, and B. O'Rourke A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network PLoS Comput Biol 6 2011 e1000657
41. D.B. Zorov, M. Juhaszova, and S.J. Sollott Mitochondrial ROS-induced ROS release: an update and review Biochim Biophys Acta 1757 2006 509 517