Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells

Brain Research

Volumn 1627, Issue , 2015, Pages 80-89

  Diaz, Brenda ^a   Fuentes Mera, Lizeth ^a   Tovar, Armando ^b   Montiel, Teresa ^c   Massieu, Lourdes ^c   Martínez Rodríguez, Herminia Guadalupe ^a   Camacho, Alberto ^a  

^a UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Endoplasmic reticulum stress; Hypothalamus; Insulin resistance; Mitofusin 2

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; INSULIN; MITOFUSIN 2; PALMITIC ACID; PALMITOLEIC ACID; SALICYLATE SODIUM; SATURATED FATTY ACID; ENZYME INHIBITOR; MTF2 PROTEIN, MOUSE; ONCOPROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPOTOXICITY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; ANIMAL; BODY WEIGHT; C57BL MOUSE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; TIME FACTOR; ULTRASTRUCTURE;

ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; HYPOTHALAMUS; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; NEURONS; ONCOGENE PROTEIN V-AKT; PALMITIC ACID; POLYCOMB REPRESSIVE COMPLEX 2; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84954222032     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.09.014     Document Type: Article

References (38)

1. A.P. Arruda, B.M. Pers, G. Parlakgul, E. Guney, K. Inouye, and G.S. Hotamisligil Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity Nat. Med. 20 2014 1427 1435
2. D. Bach, D. Naon, S. Pich, F.X. Soriano, N. Vega, J. Rieusset, M. Laville, C. Guillet, Y. Boirie, H. Wallberg-Henriksson, M. Manco, M. Calvani, M. Castagneto, M. Palacin, G. Mingrone, J.R. Zierath, H. Vidal, and A. Zorzano Expression of MTF2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 Diabetes 54 2005 2685 2693
3. R. Barazzoni, M. Zanetti, G. Gortan Cappellari, A. Semolic, M. Boschelle, E. Codarin, A. Pirulli, L. Cattin, and G. Guarnieri Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-kappaB inhibitor (IkappaB)-nuclear factor-kappaB (NFkappaB) activation in rat muscle, in the absence of mitochondrial dysfunction Diabetologia 55 2012 773 782
4. M. Bettscheider, A. Kuczynska, O. Almeida, and D. Spengler Optimized analysis of DNA methylation and gene expression from small, anatomically-defined areas of the brain J. Vis. Exp. 12 2012 e3938
5. S. Bi Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis Physiol. Behav. 121 2013 56 60
6. A. Camacho, S. Rodriguez-Cuenca, M. Blount, X. Prieur, N. Barbarroja, M. Fuller, G.E. Hardingham, and A. Vidal-Puig Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response Exp. Neurol. 237 2012 396 406
7. A. Camacho, J.K. Huang, I. Delint-Ramirez, C. Yew Tan, M. Fuller, C.J. Lelliott, A. Vidal-Puig, and R.J. Franklin Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis Eur. J. Neurosci. 38 2013 2672 2683
8. I. Delint-Ramirez, R. Maldonado Ruiz, I. Torre-Villalvazo, L. Fuentes-Mera, L. Garza Ocanas, A. Tovar, and A. Camacho Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains Neurochem. Int. 80 2015 23 32
9. M.O. Dietrich, Z.W. Liu, and T.L. Horvath Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity Cell 155 2013 188 199
10. R. Filadi, E. Greotti, G. Turacchio, A. Luini, T. Pozzan, and P. Pizzo Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling Proc. Natl. Acad. Sci. U.S.A. 112 2015 E2174 E2181
11. K.X. Gan, C. Wang, J.H. Chen, C.J. Zhu, and G.Y. Song Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats World J. Gastroenterol. 19 2013 1572 1581
12. C. Giorgi, S. Missiroli, S. Patergnani, J. Duszynski, M.R. Wieckowski, and P. Pinton Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications Antioxid. Redox Signal. 22 2015 995 1019
13. C.J. Green, K. Macrae, S. Fogarty, D.G. Hardie, K. Sakamoto, and H.S. Hundal Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappaB signalling in rat skeletal muscle cells by AMP-activated protein kinase Biochem. J. 435 2011 463 474
14. J. Kim, Y.J. Park, Y. Jang, and Y.H. Kwon AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells Brain Res. 1418 2011 42 51
15. B. Kwon, H.K. Lee, and H.W. Querfurth Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells Biochim. Biophys. Acta 1843 2014 1402 1413
16. P.J. Larsen, and N. Tennagels On ceramides, other sphingolipids and impaired glucose homeostasis Mol. Metab. 3 2014 252 260
17. V.S. Malik, W.C. Willett, and F.B. Hu Global obesity: trends, risk factors and policy implications Nat. Rev. Endocrinol. 9 2013 13 27
18. C.M. Mayer, and D.D. Belsham Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation Endocrinology 151 2010 576 585
19. G. Medina-Gomez, S.L. Gray, L. Yetukuri, K. Shimomura, S. Virtue, M. Campbell, R.K. Curtis, M. Jimenez-Linan, M. Blount, G.S. Yeo, M. Lopez, T. Seppanen-Laakso, F.M. Ashcroft, M. Oresic, and A. Vidal-Puig PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism PLoS Genet. 3 2007 e64
20. T.A. Miller, N.K. LeBrasseur, G.M. Cote, M.P. Trucillo, D.R. Pimentel, Y. Ido, N.B. Ruderman, and D.B. Sawyer Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes Biochem. Biophys. Res. Commun. 336 2005 309 315
21. Q. Nie, C. Wang, G. Song, H. Ma, D. Kong, X. Zhang, K. Gan, and Y. Tang Mitofusin 2 deficiency leads to oxidative stress that contributes to insulin resistance in rat skeletal muscle cells Mol. Biol. Rep. 41 2014 6975 6983
22. C.N. Poston, S.C. Krishnan, and C.R. Bazemore-Walker In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM) J. Proteom. 79 2013 219 230
23. L. Salvado, T. Coll, A.M. Gomez-Foix, E. Salmeron, E. Barroso, X. Palomer, and M. Vazquez-Carrera Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism Diabetologia 56 2013 1372 1382
24. J.M. Scarlett, and M.W. Schwartz Gut-brain mechanisms controlling glucose homeostasis F1000Prime Rep. 7 2015 12
25. M. Schneeberger, M.O. Dietrich, D. Sebastian, M. Imbernon, C. Castano, A. Garcia, Y. Esteban, A. Gonzalez-Franquesa, I.C. Rodriguez, A. Bortolozzi, P.M. Garcia-Roves, R. Gomis, R. Nogueiras, T.L. Horvath, A. Zorzano, and M. Claret Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance Cell 155 2013 172 187
26. D. Sebastian, M.I. Hernandez-Alvarez, J. Segales, E. Sorianello, J.P. Munoz, D. Sala, A. Waget, M. Liesa, J.C. Paz, P. Gopalacharyulu, M. Oresic, S. Pich, R. Burcelin, M. Palacin, and A. Zorzano Mitofusin 2 (MTF2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis Proc. Natl. Acad. Sci. U.S.A. 109 2012 5523 5528
27. D. Serra, P. Mera, M.I. Malandrino, J.F. Mir, and L. Herrero Mitochondrial fatty acid oxidation in obesity Antioxid. Redox Signal. 19 2013 269 284
28. E. Tubbs, P. Theurey, G. Vial, N. Bendridi, A. Bravard, M.A. Chauvin, J. Ji-Cao, F. Zoulim, B. Bartosch, M. Ovize, H. Vidal, and J. Rieusset Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance Diabetes 63 2014 3279 3294
29. A.R. van Vliet, T. Verfaillie, and P. Agostinis New functions of mitochondria associated membranes in cellular signaling Biochim. Biophys. Acta 1843 2014 2253 2262
30. A.J. Verberne, A. Sabetghadam, and W.S. Korim Neural pathways that control the glucose counterregulatory response Front. Neurosci. 8 2014 38
31. M.C. Vogt, and J.C. Bruning CNS insulin signaling in the control of energy homeostasis and glucose metabolism-from embryo to old age Trends Endocrinol. Metab. 24 2013 76 84
32. L.M. Williams Hypothalamic dysfunction in obesity Proc. Nutr. Soc. 71 2012 521 533
33. J. Yin, Z. Gao, D. Liu, Z. Liu, and J. Ye Berberine improves glucose metabolism through induction of glycolysis Am. J. Physiol. Endocrinol. Metab. 294 2008 E148 E156
34. L. Yuzefovych, G. Wilson, and L. Rachek Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress Am. J. Physiol. Endocrinol. Metab. 299 2010 E1096 E1105
35. L.V. Yuzefovych, V.A. Solodushko, G.L. Wilson, and L.I. Rachek Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells Endocrinology 153 2012 92 100
36. X. Zhang, C. Wang, G. Song, K. Gan, D. Kong, Q. Nie, and L. Ren Mitofusion-2-mediated alleviation of insulin resistance in rats through reduction in lipid intermediate accumulation in skeletal muscle J. Biomed. Sci. 20 2013 45
37. L. Zhao, X. Zou, Z. Feng, C. Luo, J. Liu, H. Li, L. Chang, H. Wang, Y. Li, J. Long, and F. Gao Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats Exp. Gerontol. 56 2014 3 12
38. A. Zorzano, M.I. Hernandez-Alvarez, M. Palacin, and G. Mingrone Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes Biochim. Biophys. Acta 1797 2010 1028 1033