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Volumn 22, Issue 27, 2016, Pages 6100-6113

Diabetes mellitus and metformin in hepatocellular carcinoma

Author keywords

Diabetes mellitus; Hepatocellular carcinoma; Metformin; Risk

Indexed keywords

ADEFOVIR; ADIPOCYTOKINE; ENTECAVIR; ESTROGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LAMIVUDINE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MICRORNA; PLACEBO; PROTEIN KINASE LKB1; ROSIGLITAZONE; SOMATOMEDIN C; SORAFENIB; TENOFOVIR; ANTIDIABETIC AGENT;

EID: 84978474612     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v22.i27.6100     Document Type: Article
Times cited : (55)

References (170)
  • 1
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • PMID: 22537432
    • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012; 142: 1264-1273.e1 [PMID: 22537432 DOI: 10.1200/JCO.2008.20.7753]
    • (2012) Gastroenterology , vol.142 , pp. 1264e1-1273e1
    • El-Serag, H.B.1
  • 2
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • PMID: 19224838
    • Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009; 27: 1485-1491 [PMID: 19224838]
    • (2009) J Clin Oncol , vol.27 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 4
    • 0036120649 scopus 로고    scopus 로고
    • Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma
    • PMID: 11894036
    • Regimbeau JM, Kianmanesh R, Farges O, Dondero F, Sauvanet A, Belghiti J. Extent of liver resection influences the outcome in patients with cirrhosis and small hepatocellular carcinoma. Surgery 2002; 131: 311-317 [PMID: 11894036 DOI: 10.1067/msy.2002.121892]
    • (2002) Surgery , vol.131 , pp. 311-317
    • Regimbeau, J.M.1    Kianmanesh, R.2    Farges, O.3    Dondero, F.4    Sauvanet, A.5    Belghiti, J.6
  • 6
    • 84880948632 scopus 로고    scopus 로고
    • Comparison of resection and ablation for hepatocellular carcinoma: A cohort study based on a Japanese nationwide survey
    • PMID: 23178708
    • Hasegawa K, Kokudo N, Makuuchi M, Izumi N, Ichida T, Kudo M, Ku Y, Sakamoto M, Nakashima O, Matsui O, Matsuyama Y. Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey. J Hepatol 2013; 58: 724-729 [PMID: 23178708 DOI: 10.1016/j.jhep.2012.11.009]
    • (2013) J Hepatol , vol.58 , pp. 724-729
    • Hasegawa, K.1    Kokudo, N.2    Makuuchi, M.3    Izumi, N.4    Ichida, T.5    Kudo, M.6    Ku, Y.7    Sakamoto, M.8    Nakashima, O.9    Matsui, O.10    Matsuyama, Y.11
  • 8
    • 22644441192 scopus 로고    scopus 로고
    • Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less
    • PMID: 16009687
    • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less. Gut 2005; 54: 1151-1156 [PMID: 16009687 DOI: 10.1136/gut.2004.045203]
    • (2005) Gut , vol.54 , pp. 1151-1156
    • Lin, S.M.1    Lin, C.J.2    Lin, C.C.3    Hsu, C.W.4    Chen, Y.C.5
  • 9
    • 0036189906 scopus 로고    scopus 로고
    • Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: Implications for a strategy of salvage transplantation
    • PMID: 11882759
    • Poon RT, Fan ST, Lo CM, Liu CL, Wong J. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation. Ann Surg 2002; 235: 373-382 [PMID: 11882759 DOI: 10.1097/00000658-200203000-00009]
    • (2002) Ann Surg , vol.235 , pp. 373-382
    • Poon, R.T.1    Fan, S.T.2    Lo, C.M.3    Liu, C.L.4    Wong, J.5
  • 10
    • 33847610604 scopus 로고    scopus 로고
    • Factors predictive for long-term survival of male patients with hepatocellular carcinoma after curative resection
    • PMID: 17326130
    • Zhou L, Rui JA, Wang SB, Chen SG, Qu Q, Chi TY, Wei X, Han K, Zhang N, Zhao HT. Factors predictive for long-term survival of male patients with hepatocellular carcinoma after curative resection. J Surg Oncol 2007; 95: 298-303 [PMID: 17326130 DOI: 10.1002/jso.20678]
    • (2007) J Surg Oncol , vol.95 , pp. 298-303
    • Zhou, L.1    Rui, J.A.2    Wang, S.B.3    Chen, S.G.4    Qu, Q.5    Chi, T.Y.6    Wei, X.7    Han, K.8    Zhang, N.9    Zhao, H.T.10
  • 11
    • 84897962235 scopus 로고    scopus 로고
    • Postoperative recurrence pattern and prognosis of patients with hepatocellular carcinoma, with particular reference to the hepatitis viral infection status
    • PMID: 24350618
    • Naito S, Imamura H, Tukada A, Matsuyama Y, Yoshimoto J, Sugo H, Ishizaki Y, Kawasaki S. Postoperative recurrence pattern and prognosis of patients with hepatocellular carcinoma, with particular reference to the hepatitis viral infection status. Liver Int 2014; 34: 802-813 [PMID: 24350618 DOI: 10.1111/liv.12447]
    • (2014) Liver Int , vol.34 , pp. 802-813
    • Naito, S.1    Imamura, H.2    Tukada, A.3    Matsuyama, Y.4    Yoshimoto, J.5    Sugo, H.6    Ishizaki, Y.7    Kawasaki, S.8
  • 12
    • 84924902011 scopus 로고    scopus 로고
    • Short-and longterm outcomes of hepatectomy with or without radiofrequencyassist for the treatment of hepatocellular carcinomas: A retrospective comparative cohort study
    • PMID: 25787911
    • Guo R, Feng X, Xiao S, Yan J, Xia F, Ma K, Li X. Short-and longterm outcomes of hepatectomy with or without radiofrequencyassist for the treatment of hepatocellular carcinomas: a retrospective comparative cohort study. Biosci Trends 2015; 9: 65-72 [PMID: 25787911 DOI: 10.5582/bst.2014.01142]
    • (2015) Biosci Trends , vol.9 , pp. 65-72
    • Guo, R.1    Feng, X.2    Xiao, S.3    Yan, J.4    Xia, F.5    Ma, K.6    Li, X.7
  • 13
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
    • PMID: 12049862
    • Llovet JM, Real MI, Montaña X, Planas R, Coll S, Aponte J, Ayuso C, Sala M, Muchart J, Solà R, Rodés J, Bruix J. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002; 359: 1734-1739 [PMID: 12049862 DOI: 10.1016/S0140-6736(02)08649-X]
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montaña, X.3    Planas, R.4    Coll, S.5    Aponte, J.6    Ayuso, C.7    Sala, M.8    Muchart, J.9    Solà, R.10    Rodés, J.11    Bruix, J.12
  • 14
    • 0036237822 scopus 로고    scopus 로고
    • Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    • PMID: 11981766
    • Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT, Fan ST, Wong J. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002; 35: 1164-1171 [PMID: 11981766 DOI: 10.1053/jhep.2002.33156]
    • (2002) Hepatology , vol.35 , pp. 1164-1171
    • Lo, C.M.1    Ngan, H.2    Tso, W.K.3    Liu, C.L.4    Lam, C.M.5    Poon, R.T.6    Fan, S.T.7    Wong, J.8
  • 18
    • 36849048122 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular carcinoma in Asia
    • PMID: 18055852
    • de Villa V, Lo CM. Liver transplantation for hepatocellular carcinoma in Asia. Oncologist 2007; 12: 1321-1331 [PMID: 18055852 DOI: 10.1634/theoncologist.12-11-1321]
    • (2007) Oncologist , vol.12 , pp. 1321-1331
    • De Villa, V.1    Lo, C.M.2
  • 24
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomised, phase 2 trial
    • PMID: 24209977
    • Lawitz E, Poordad FF, Pang PS, Hyland RH, Ding X, Mo H, Symonds WT, McHutchison JG, Membreno FE. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial. Lancet 2014; 383: 515-523 [PMID: 24209977 DOI: 10.1016/S0140-6736(13)62121-2]
    • (2014) Lancet , vol.383 , pp. 515-523
    • Lawitz, E.1    Poordad, F.F.2    Pang, P.S.3    Hyland, R.H.4    Ding, X.5    Mo, H.6    Symonds, W.T.7    McHutchison, J.G.8    Membreno, F.E.9
  • 26
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • PMID: 15849206
    • Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330: 1304-1305 [PMID: 15849206 DOI: 10.1136/bmj.38415.708634.F7]
    • (2005) BMJ , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3    Alessi, D.R.4    Morris, A.D.5
  • 28
    • 84898017095 scopus 로고    scopus 로고
    • Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States
    • PMID: 24513805
    • Altekruse SF, Henley SJ, Cucinelli JE, McGlynn KA. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol 2014; 109: 542-553 [PMID: 24513805 DOI: 10.1038/ajg.2014.11]
    • (2014) Am J Gastroenterol , vol.109 , pp. 542-553
    • Altekruse, S.F.1    Henley, S.J.2    Cucinelli, J.E.3    McGlynn, K.A.4
  • 29
    • 84920955313 scopus 로고    scopus 로고
    • Emerging trends in hepatocellular carcinoma incidence and mortality
    • PMID: 25142309
    • Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology 2015; 61: 191-199 [PMID: 25142309 DOI: 10.1002/hep.27388]
    • (2015) Hepatology , vol.61 , pp. 191-199
    • Njei, B.1    Rotman, Y.2    Ditah, I.3    Lim, J.K.4
  • 30
    • 79952277505 scopus 로고    scopus 로고
    • The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective
    • PMID: 21115576
    • Venook AP, Papandreou C, Furuse J, de Guevara LL. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 2010; 15. Suppl 4: 5-13 [PMID: 21115576 DOI: 10.1634/theoncologist.2010-S4-05]
    • (2010) Oncologist , vol.15 , pp. 5-13
    • Venook, A.P.1    Papandreou, C.2    Furuse, J.3    De Guevara, L.L.4
  • 31
    • 84892971035 scopus 로고    scopus 로고
    • Local geographic variation in chronic liver disease and hepatocellular carcinoma: Contributions of socioeconomic deprivation, alcohol retail outlets, and lifestyle
    • PMID: 24332863
    • Major JM, Sargent JD, Graubard BI, Carlos HA, Hollenbeck AR, Altekruse SF, Freedman ND, McGlynn KA. Local geographic variation in chronic liver disease and hepatocellular carcinoma: contributions of socioeconomic deprivation, alcohol retail outlets, and lifestyle. Ann Epidemiol 2014; 24: 104-110 [PMID: 24332863 DOI: 10.1016/j.annepidem.2013.11.006]
    • (2014) Ann Epidemiol , vol.24 , pp. 104-110
    • Major, J.M.1    Sargent, J.D.2    Graubard, B.I.3    Carlos, H.A.4    Hollenbeck, A.R.5    Altekruse, S.F.6    Freedman, N.D.7    McGlynn, K.A.8
  • 32
    • 34547095281 scopus 로고    scopus 로고
    • Distinctive change in male liver cancer incidence rate between the 1970s and 1990s in Japan: Comparison with Japanese-Americans and US whites
    • PMID: 17332055
    • Tanaka H, Uera F, Tsukuma H, Ioka A, Oshima A. Distinctive change in male liver cancer incidence rate between the 1970s and 1990s in Japan: comparison with Japanese-Americans and US whites. Jpn J Clin Oncol 2007; 37: 193-196 [PMID: 17332055 DOI: 10.1093/jjco/hyl148]
    • (2007) Jpn J Clin Oncol , vol.37 , pp. 193-196
    • Tanaka, H.1    Uera, F.2    Tsukuma, H.3    Ioka, A.4    Oshima, A.5
  • 33
    • 17344369924 scopus 로고    scopus 로고
    • Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C Osaka Liver Disease Study Group
    • PMID: 9581697
    • Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, Urushihara A, Kiyosawa K, Okuda M, Hino K, Okita K. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology 1998; 27: 1394-1402 [PMID: 9581697 DOI: 10.1002/hep.510270529]
    • (1998) Hepatology , vol.27 , pp. 1394-1402
    • Kasahara, A.1    Hayashi, N.2    Mochizuki, K.3    Takayanagi, M.4    Yoshioka, K.5    Kakumu, S.6    Iijima, A.7    Urushihara, A.8    Kiyosawa, K.9    Okuda, M.10    Hino, K.11    Okita, K.12
  • 38
    • 51349107091 scopus 로고    scopus 로고
    • Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigenpositive chronic hepatitis B
    • PMID: 18752330
    • Marcellin P, Chang TT, Lim SG, Sievert W, Tong M, Arterburn S, Borroto-Esoda K, Frederick D, Rousseau F. Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigenpositive chronic hepatitis B. Hepatology 2008; 48: 750-758 [PMID: 18752330 DOI: 10.1002/hep.22414]
    • (2008) Hepatology , vol.48 , pp. 750-758
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3    Sievert, W.4    Tong, M.5    Arterburn, S.6    Borroto-Esoda, K.7    Frederick, D.8    Rousseau, F.9
  • 39
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • PMID: 9727886
    • King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998; 21: 1414-1431 [PMID: 9727886 DOI: 10.2337/diacare.21.9.1414]
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 40
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • PMID: 19896746
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010; 87: 4-14 [PMID: 19896746 DOI: 10.1016/j.diabres.2009.10.007]
    • (2010) Diabetes Res Clin Pract , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 41
    • 51849146897 scopus 로고    scopus 로고
    • Global burden of obesity in 2005 and projections to 2030
    • PMID: 18607383
    • Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008; 32: 1431-1437 [PMID: 18607383 DOI: 10.1038/ijo.2008.102]
    • (2008) J Obes (Lond) , vol.32 , pp. 1431-1437
    • Kelly, T.1    Yang, W.2    Chen, C.S.3    Reynolds, K.4    He, J.5
  • 42
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • PMID: 15111519
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-1053 [PMID: 15111519 DOI: 10.2337/diacare.27.5.1047]
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 43
    • 77957102090 scopus 로고
    • A statistical study in cancer death-rates
    • Maynard GD. A statistical study in cancer death-rates. Biometrik 1910: 7: 276-304 [DOI: 10.1093/biomet/7.3.276]
    • (1910) Biometrik , vol.7 , pp. 276-304
    • Maynard, G.D.1
  • 44
    • 84863744857 scopus 로고
    • The Relation between the Cancer and Diabetes Death-rates
    • PMID: 20474569
    • Greenwood M, Wood F. The Relation between the Cancer and Diabetes Death-rates. J Hyg (Lond) 1914; 14: 83-118 [PMID: 20474569]
    • (1914) J Hyg (Lond) , vol.14 , pp. 83-118
    • Greenwood, M.1    Wood, F.2
  • 45
    • 0006660588 scopus 로고
    • Diabetes and cancer
    • Marble A. Diabetes and cancer. N Engl J Med 1934; 211: 339-349 [DOI: 10.1056/NEJM193408232110801]
    • (1934) N Engl J Med , vol.211 , pp. 339-349
    • Marble, A.1
  • 46
    • 0014761971 scopus 로고
    • Cancer mortality among diabetics
    • PMID: 11515436
    • Kessler II. Cancer mortality among diabetics. J Natl Cancer Inst 1970; 44: 673-686 [PMID: 11515436]
    • (1970) J Natl Cancer Inst , vol.44 , pp. 673-686
    • Kessler, I.I.1
  • 50
    • 0030774675 scopus 로고    scopus 로고
    • Cancer incidence in a populationbased cohort of patients hospitalized with diabetes mellitus in Denmark
    • PMID: 9308706
    • Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, Borch-Johnsen K, Olsen JH. Cancer incidence in a populationbased cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 1997; 89: 1360-1365 [PMID: 9308706 DOI: 10.1093/jnci/89.18.1360]
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1360-1365
    • Wideroff, L.1    Gridley, G.2    Mellemkjaer, L.3    Chow, W.H.4    Linet, M.5    Keehn, S.6    Borch-Johnsen, K.7    Olsen, J.H.8
  • 51
    • 0028047034 scopus 로고
    • A casecontrol study of diabetes mellitus and cancer risk
    • PMID: 7947103
    • La Vecchia C, Negri E, Franceschi S, D'Avanzo B, Boyle P. A casecontrol study of diabetes mellitus and cancer risk. Br J Cancer 1994; 70: 950-953 [PMID: 7947103 DOI: 10.1038/bjc.1994.427]
    • (1994) Br J Cancer , vol.70 , pp. 950-953
    • La Vecchia, C.1    Negri, E.2    Franceschi, S.3    D'Avanzo, B.4    Boyle, P.5
  • 52
    • 0035346964 scopus 로고    scopus 로고
    • Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: The Paris Prospective Study
    • PMID: 11347741
    • Balkau B, Kahn HS, Courbon D, Eschwège E, Ducimetière P. Hyperinsulinemia predicts fatal liver cancer but is inversely associated with fatal cancer at some other sites: the Paris Prospective Study. Diabetes Care 2001; 24: 843-849 [PMID: 11347741 DOI: 10.2337/diacare.24.5.843]
    • (2001) Diabetes Care , vol.24 , pp. 843-849
    • Balkau, B.1    Kahn, H.S.2    Courbon, D.3    Eschwège, E.4    Ducimetière, P.5
  • 53
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • PMID: 21241523
    • Lee MS, Hsu CC, Wahlqvist ML, Tsai HN, Chang YH, Huang YC. Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 2011; 11: 20 [PMID: 21241523 DOI: 10.1186/1471-2407-11-20]
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 55
    • 0842309669 scopus 로고    scopus 로고
    • Diabetes mellitus is a recurrence-independent risk factor in patients with hepatitis B virus-related hepatocellular carcinoma undergoing resection
    • PMID: 14560154
    • Huo TI, Wu JC, Lui WY, Lee PC, Huang YH, Chau GY, Tsay SH, Chang FY, Lee SD. Diabetes mellitus is a recurrence-independent risk factor in patients with hepatitis B virus-related hepatocellular carcinoma undergoing resection. Eur J Gastroenterol Hepatol 2003; 15: 1203-1208 [PMID: 14560154 DOI: 10.1097/01. meg.0000085498.01212.6a]
    • (2003) Eur J Gastroenterol Hepatol , vol.15 , pp. 1203-1208
    • Huo, T.I.1    Wu, J.C.2    Lui, W.Y.3    Lee, P.C.4    Huang, Y.H.5    Chau, G.Y.6    Tsay, S.H.7    Chang, F.Y.8    Lee, S.D.9
  • 57
    • 56549090051 scopus 로고    scopus 로고
    • Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis
    • PMID: 18713301
    • Kawamura Y, Ikeda K, Arase Y, Yatsuji H, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Saitoh S, Suzuki F, Suzuki Y, Kumada H. Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis. J Gastroenterol Hepatol 2008; 23: 1739-1746 [PMID: 18713301 DOI: 10.1111/j.1440-1746.2008.05436.x]
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1739-1746
    • Kawamura, Y.1    Ikeda, K.2    Arase, Y.3    Yatsuji, H.4    Sezaki, H.5    Hosaka, T.6    Akuta, N.7    Kobayashi, M.8    Saitoh, S.9    Suzuki, F.10    Suzuki, Y.11    Kumada, H.12
  • 58
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
    • PMID: 15191933
    • Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol 2004; 159: 1160-1167 [PMID: 15191933 DOI: 10.1093/aje/kwh161]
    • (2004) Am J Epidemiol , vol.159 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3    Petrelli, J.4    Thun, M.J.5
  • 59
    • 77951520019 scopus 로고    scopus 로고
    • The relationship between glycaemic control and mortality in patients with type 2 diabetes in general practice (ZODIAC-11)
    • PMID: 20202363
    • Landman GW, van Hateren KJ, Kleefstra N, Groenier KH, Gans RO, Bilo HJ. The relationship between glycaemic control and mortality in patients with type 2 diabetes in general practice (ZODIAC-11). Br J Gen Pract 2010; 60: 172-175 [PMID: 20202363 DOI: 10.3399/bjgp10X483517]
    • (2010) Br J Gen Pract , vol.60 , pp. 172-175
    • Landman, G.W.1    Van Hateren, K.J.2    Kleefstra, N.3    Groenier, K.H.4    Gans, R.O.5    Bilo, H.J.6
  • 60
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence
    • PMID: 16527702
    • El-Serag HB, Hampel H, Javadi F. The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 2006; 4: 369-380 [PMID: 16527702 DOI: 10.1016/j.cgh.2005.12.007]
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 63
    • 84875463056 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study
    • PMID: 23370206
    • Koh WP, Wang R, Jin A, Yu MC, Yuan JM. Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study. Br J Cancer 2013; 108: 1182-1188 [PMID: 23370206 DOI: 10.1038/bjc.2013.25]
    • (2013) Br J Cancer , vol.108 , pp. 1182-1188
    • Koh, W.P.1    Wang, R.2    Jin, A.3    Yu, M.C.4    Yuan, J.M.5
  • 64
    • 33749031867 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of cancer: Results from a large-scale population-based cohort study in Japan
    • PMID: 17000944
    • Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S. Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 2006; 166: 1871-1877 [PMID: 17000944 DOI: 10.1001/archinte.166.17.1871]
    • (2006) Arch Intern Med , vol.166 , pp. 1871-1877
    • Inoue, M.1    Iwasaki, M.2    Otani, T.3    Sasazuki, S.4    Noda, M.5    Tsugane, S.6
  • 65
    • 0028302476 scopus 로고
    • Obesity and cancer risk: A Danish record-linkage study
    • PMID: 8204357
    • Møller H, Mellemgaard A, Lindvig K, Olsen JH. Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer 1994; 30A: 344-350 [PMID: 8204357]
    • (1994) Eur J Cancer , vol.30 A , pp. 344-350
    • Møller, H.1    Mellemgaard, A.2    Lindvig, K.3    Olsen, J.H.4
  • 67
    • 0025379453 scopus 로고
    • Post-load plasma glucose and cancer mortality in middle-aged men and women 12-year follow-up findings of the Chicago Heart Association Detection Project in Industry
    • PMID: 2296978
    • Levine W, Dyer AR, Shekelle RB, Schoenberger JA, Stamler J. Post-load plasma glucose and cancer mortality in middle-aged men and women. 12-year follow-up findings of the Chicago Heart Association Detection Project in Industry. Am J Epidemiol 1990; 131: 254-262 [PMID: 2296978]
    • (1990) Am J Epidemiol , vol.131 , pp. 254-262
    • Levine, W.1    Dyer, A.R.2    Shekelle, R.B.3    Schoenberger, J.A.4    Stamler, J.5
  • 68
    • 10844253820 scopus 로고    scopus 로고
    • Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: Findings from the original Whitehall study
    • PMID: 15577289
    • Batty GD, Shipley MJ, Marmot M, Smith GD. Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study. Cancer Causes Control 2004; 15: 873-881 [PMID: 15577289 DOI: 10.1007/s10552-004-1050-z]
    • (2004) Cancer Causes Control , vol.15 , pp. 873-881
    • Batty, G.D.1    Shipley, M.J.2    Marmot, M.3    Smith, G.D.4
  • 69
    • 84921901606 scopus 로고    scopus 로고
    • Cancer risk among people with type 1 and type 2 diabetes: Disentangling true associations, detection bias, and reverse causation
    • PMID: 25488912
    • Harding JL, Shaw JE, Peeters A, Cartensen B, Magliano DJ. Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation. Diabetes Care 2015; 38: 264-270 [PMID: 25488912 DOI: 10.2337/dc14-1996]
    • (2015) Diabetes Care , vol.38 , pp. 264-270
    • Harding, J.L.1    Shaw, J.E.2    Peeters, A.3    Cartensen, B.4    Magliano, D.J.5
  • 70
    • 80054693912 scopus 로고    scopus 로고
    • Time-varying incidence of cancer after the onset of type 2 diabetes: Evidence of potential detection bias
    • PMID: 21748485
    • Johnson JA, Bowker SL, Richardson K, Marra CA. Time-varying incidence of cancer after the onset of type 2 diabetes: evidence of potential detection bias. Diabetologia 2011; 54: 2263-2271 [PMID: 21748485 DOI: 10.1007/s00125-011-2242-1]
    • (2011) Diabetologia , vol.54 , pp. 2263-2271
    • Johnson, J.A.1    Bowker, S.L.2    Richardson, K.3    Marra, C.A.4
  • 71
    • 49649092692 scopus 로고    scopus 로고
    • Obesity and diabetes epidemics: Cancer repercussions
    • PMID: 18637486
    • Hjartåker A, Langseth H, Weiderpass E. Obesity and diabetes epidemics: cancer repercussions. Adv Exp Med Biol 2008; 630: 72-93 [PMID: 18637486]
    • (2008) Adv Exp Med Biol , vol.630 , pp. 72-93
    • Hjartåker, A.1    Langseth, H.2    Weiderpass, E.3
  • 72
    • 54349093798 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors and neoplasia
    • PMID: 18971123
    • Pollak M. Insulin, insulin-like growth factors and neoplasia. Best Pract Res Clin Endocrinol Metab 2008; 22: 625-638 [PMID: 18971123 DOI: 10.1016/j.beem.2008.08.004]
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 625-638
    • Pollak, M.1
  • 73
    • 0026052697 scopus 로고
    • Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1
    • PMID: 1717456
    • Powell DR, Suwanichkul A, Cubbage ML, DePaolis LA, Snuggs MB, Lee PD. Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1. J Biol Chem 1991; 266: 18868-18876 [PMID: 1717456]
    • (1991) J Biol Chem , vol.266 , pp. 18868-18876
    • Powell, D.R.1    Suwanichkul, A.2    Cubbage, M.L.3    DePaolis, L.A.4    Snuggs, M.B.5    Lee, P.D.6
  • 74
    • 0027051126 scopus 로고
    • Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats
    • PMID: 1283442
    • Ooi GT, Tseng LY, Tran MQ, Rechler MM. Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats. Mol Endocrinol 1992; 6: 2219-2228 [PMID: 1283442 DOI: 10.1210/mend.6.12.1283442]
    • (1992) Mol Endocrinol , vol.6 , pp. 2219-2228
    • Ooi, G.T.1    Tseng, L.Y.2    Tran, M.Q.3    Rechler, M.M.4
  • 75
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • PMID: 22500797
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149: 274-293 [PMID: 22500797 DOI: 10.1016/j.cell.2012.03.017]
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 76
    • 84942365068 scopus 로고    scopus 로고
    • Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma
    • PMID: 26123841
    • Chettouh H, Lequoy M, Fartoux L, Vigouroux C, Desbois-Mouthon C. Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma. Liver Int 2015; 35: 2203-2217 [PMID: 26123841 DOI: 10.1111/liv.12903]
    • (2015) Liver Int , vol.35 , pp. 2203-2217
    • Chettouh, H.1    Lequoy, M.2    Fartoux, L.3    Vigouroux, C.4    Desbois-Mouthon, C.5
  • 77
    • 84909991205 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor pathway in hepatocellular carcinoma
    • PMID: 25349643
    • Enguita-Germán M, Fortes P. Targeting the insulin-like growth factor pathway in hepatocellular carcinoma. World J Hepatol 2014; 6: 716-737 [PMID: 25349643 DOI: 10.4254/wjh.v6.i10.716]
    • (2014) World J Hepatol , vol.6 , pp. 716-737
    • Enguita-Germán, M.1    Fortes, P.2
  • 79
    • 84892476014 scopus 로고    scopus 로고
    • Diabetes and cancer: Two diseases with obesity as a common risk factor
    • PMID: 23668396
    • Garg SK, Maurer H, Reed K, Selagamsetty R. Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab 2014; 16: 97-110 [PMID: 23668396 DOI: 10.1111/dom.12124]
    • (2014) Diabetes Obes Metab , vol.16 , pp. 97-110
    • Garg, S.K.1    Maurer, H.2    Reed, K.3    Selagamsetty, R.4
  • 80
    • 84862819412 scopus 로고    scopus 로고
    • Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells
    • PMID: 22289780
    • Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. Biochim Biophys Acta 2012; 1825: 207-222 [PMID: 22289780 DOI: 10.1016/j.bbcan.2012.01.002]
    • (2012) Biochim Biophys Acta , vol.1825 , pp. 207-222
    • Guo, S.1    Liu, M.2    Wang, G.3    Torroella-Kouri, M.4    Gonzalez-Perez, R.R.5
  • 81
    • 68149131125 scopus 로고    scopus 로고
    • Obesity related hyperinsulinaemia and hyperglycaemia and cancer development
    • PMID: 19485704
    • Becker S, Dossus L, Kaaks R. Obesity related hyperinsulinaemia and hyperglycaemia and cancer development. Arch Physiol Biochem 2009; 115: 86-96 [PMID: 19485704 DOI: 10.1080/13813450902878 054]
    • (2009) Arch Physiol Biochem , vol.115 , pp. 86-96
    • Becker, S.1    Dossus, L.2    Kaaks, R.3
  • 82
    • 84881558451 scopus 로고    scopus 로고
    • Obesity, adipokines and hepatocellular carcinoma
    • PMID: 23404222
    • Duan XF, Tang P, Li Q, Yu ZT. Obesity, adipokines and hepatocellular carcinoma. Int J Cancer 2013; 133: 1776-1783 [PMID: 23404222 DOI: 10.1002/ijc.28105]
    • (2013) J Cancer , vol.133 , pp. 1776-1783
    • Duan, X.F.1    Tang, P.2    Li, Q.3    Yu, Z.T.4
  • 83
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • PMID: 13298683
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314 [PMID: 13298683 DOI: 10.1126/science.123.3191.309]
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 84
    • 42049121240 scopus 로고    scopus 로고
    • Warburg revisited: Imaging tumour blood flow and metabolism
    • PMID: 18390391
    • Miles KA, Williams RE. Warburg revisited: imaging tumour blood flow and metabolism. Cancer Imaging 2008; 8: 81-86 [PMID: 18390391 DOI: 10.1102/1470-7330.2008.0011]
    • (2008) Cancer Imaging , vol.8 , pp. 81-86
    • Miles, K.A.1    Williams, R.E.2
  • 86
    • 84924968664 scopus 로고    scopus 로고
    • Hyperglycemia and chronic liver diseases on risk of hepatocellular carcinoma in Chinese patients with type 2 diabetes-National cohort of Taiwan Diabetes Study
    • PMID: 25387451
    • Li CI, Chen HJ, Lai HC, Liu CS, Lin WY, Li TC, Lin CC. Hyperglycemia and chronic liver diseases on risk of hepatocellular carcinoma in Chinese patients with type 2 diabetes-National cohort of Taiwan Diabetes Study. Int J Cancer 2015; 136: 2668-2679 [PMID: 25387451 DOI: 10.1002/ijc.29321]
    • (2015) J Cancer , vol.136 , pp. 2668-2679
    • Li, C.I.1    Chen, H.J.2    Lai, H.C.3    Liu, C.S.4    Lin, W.Y.5    Li, T.C.6    Lin, C.C.7
  • 88
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: A meta-analysis of major trials
    • PMID: 20959956
    • Johnson JA, Bowker SL. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 2011; 54: 25-31 [PMID: 20959956 DOI: 10.1007/s00125-010-1933-3]
    • (2011) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 89
    • 79953764330 scopus 로고    scopus 로고
    • Meta-analysis of trial data may support a causal role of hyperglycaemia in cancer
    • author reply 711-712, [PMID: 21153895]
    • Yang XL, Ma RC, Chan JC. Meta-analysis of trial data may support a causal role of hyperglycaemia in cancer. Diabetologia 2011; 54: 709-710; author reply 711-712 [PMID: 21153895 DOI: 10.1007/s00125-010-2017-0]
    • (2011) Diabetologia , vol.54 , pp. 709-710
    • Yang, X.L.1    Ma, R.C.2    Chan, J.C.3
  • 90
    • 84929961472 scopus 로고    scopus 로고
    • Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers
    • PMID: 25555473
    • Brown SB, Hankinson SE. Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids 2015; 99: 8-10 [PMID: 25555473 DOI: 10.1016/j.steroids.2014.12.013]
    • (2015) Steroids , vol.99 , pp. 8-10
    • Brown, S.B.1    Hankinson, S.E.2
  • 91
    • 0035200712 scopus 로고    scopus 로고
    • Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States
    • PMID: 11124821
    • El-Serag HB, Mason AC, Key C. Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States. Hepatology 2001; 33: 62-65 [PMID: 11124821 DOI: 10.1053/jhep.2001.21041]
    • (2001) Hepatology , vol.33 , pp. 62-65
    • El-Serag, H.B.1    Mason, A.C.2    Key, C.3
  • 93
    • 84899493218 scopus 로고    scopus 로고
    • Role of estrogen in hepatocellular carcinoma: Is inflammation the key
    • PMID: 24708807
    • Shi L, Feng Y, Lin H, Ma R, Cai X. Role of estrogen in hepatocellular carcinoma: is inflammation the key? J Transl Med 2014; 12: 93 [PMID: 24708807 DOI: 10.1186/1479-5876-12-93]
    • (2014) J Transl Med , vol.12 , pp. 93
    • Shi, L.1    Feng, Y.2    Lin, H.3    Ma, R.4    Cai, X.5
  • 94
    • 57349160286 scopus 로고    scopus 로고
    • Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • PMID: 18941734
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2009; 52: 17-30 [PMID: 18941734 DOI: 10.1007/s00125-008-1157-y]
    • (2009) Diabetologia , vol.52 , pp. 17-30
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 95
    • 0024330279 scopus 로고
    • Traditional plant medicines as treatments for diabetes
    • PMID: 2673695
    • Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989; 12: 553-564 [PMID: 2673695 DOI: 10.2337/diacare.12.8.553]
    • (1989) Diabetes Care , vol.12 , pp. 553-564
    • Bailey, C.J.1    Day, C.2
  • 96
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • PMID: 16443869
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006; 29: 254-258 [PMID: 16443869 DOI: 10.2337/diacare.29.02.06.dc05-1558]
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 97
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • PMID: 19564453
    • Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009; 32: 1620-1625 [PMID: 19564453 DOI: 10.2337/dc08-2175]
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 99
    • 77954365681 scopus 로고    scopus 로고
    • Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
    • PMID: 20331505
    • Donadon V, Balbi M, Mas MD, Casarin P, Zanette G. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int 2010; 30: 750-758 [PMID: 20331505 DOI: 10.1111/j.1478-3231.2010.02223.x]
    • (2010) Liver Int , vol.30 , pp. 750-758
    • Donadon, V.1    Balbi, M.2    Mas, M.D.3    Casarin, P.4    Zanette, G.5
  • 101
    • 84855432249 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: A population-based cohort study
    • PMID: 22085817
    • Lai SW, Chen PC, Liao KF, Muo CH, Lin CC, Sung FC. Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study. Am J Gastroenterol 2012; 107: 46-52 [PMID: 22085817 DOI: 10.1038/ajg.2011.384]
    • (2012) Am J Gastroenterol , vol.107 , pp. 46-52
    • Lai, S.W.1    Chen, P.C.2    Liao, K.F.3    Muo, C.H.4    Lin, C.C.5    Sung, F.C.6
  • 102
    • 84869788946 scopus 로고    scopus 로고
    • Metformin and the risk of cancer: Time-related biases in observational studies
    • PMID: 23173135
    • Suissa S, Azoulay L. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care 2012; 35: 2665-2673 [PMID: 23173135 DOI: 10.2337/dc12-0788]
    • (2012) Diabetes Care , vol.35 , pp. 2665-2673
    • Suissa, S.1    Azoulay, L.2
  • 103
    • 84865414136 scopus 로고    scopus 로고
    • Diabetes and cancer (1): Evaluating the temporal relationship between type 2 diabetes and cancer incidence
    • PMID: 22476947
    • Johnson JA, Carstensen B, Witte D, Bowker SL, Lipscombe L, Renehan AG. Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence. Diabetologia 2012; 55: 1607-1618 [PMID: 22476947 DOI: 10.1007/s00125-012-2525-1]
    • (2012) Diabetologia , vol.55 , pp. 1607-1618
    • Johnson, J.A.1    Carstensen, B.2    Witte, D.3    Bowker, S.L.4    Lipscombe, L.5    Renehan, A.G.6
  • 106
    • 84907296915 scopus 로고    scopus 로고
    • Metformin and cancer risk and mortality: A systematic review and meta-analysis taking into account biases and confounders
    • PMID: 24985407
    • Gandini S, Puntoni M, Heckman-Stoddard BM, Dunn BK, Ford L, DeCensi A, Szabo E. Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res (Phila) 2014; 7: 867-885 [PMID: 24985407 DOI: 10.1158/1940-6207.CAPR-13-0424]
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 867-885
    • Gandini, S.1    Puntoni, M.2    Heckman-Stoddard, B.M.3    Dunn, B.K.4    Ford, L.5    DeCensi, A.6    Szabo, E.7
  • 107
    • 77955558076 scopus 로고    scopus 로고
    • Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials
    • PMID: 20532476
    • Home PD, Kahn SE, Jones NP, Noronha D, Beck-Nielsen H, Viberti G. Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials. Diabetologia 2010; 53: 1838-1845 [PMID: 20532476 DOI: 10.1007/s00125-010-1804-y]
    • (2010) Diabetologia , vol.53 , pp. 1838-1845
    • Home, P.D.1    Kahn, S.E.2    Jones, N.P.3    Noronha, D.4    Beck-Nielsen, H.5    Viberti, G.6
  • 109
    • 84879552899 scopus 로고    scopus 로고
    • Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: A meta-analysis using primary data of published studies
    • PMID: 23419783
    • Thakkar B, Aronis KN, Vamvini MT, Shields K, Mantzoros CS. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism 2013; 62: 922-934 [PMID: 23419783 DOI: 10.1016/j.metabol.2013.01.014]
    • (2013) Metabolism , vol.62 , pp. 922-934
    • Thakkar, B.1    Aronis, K.N.2    Vamvini, M.T.3    Shields, K.4    Mantzoros, C.S.5
  • 110
    • 84890016628 scopus 로고    scopus 로고
    • Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and meta-analysis
    • PMID: 24258613
    • Yin M, Zhou J, Gorak EJ, Quddus F. Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis. Oncologist 2013; 18: 1248-1255 [PMID: 24258613 DOI: 10.1634/theoncologist.2013-0111]
    • (2013) Oncologist , vol.18 , pp. 1248-1255
    • Yin, M.1    Zhou, J.2    Gorak, E.J.3    Quddus, F.4
  • 111
    • 84957578772 scopus 로고    scopus 로고
    • The Impact of Diabetes Mellitus and Metformin Treatment on Survival of Patients with Advanced Pancreatic Cancer Undergoing Chemotherapy
    • PMID: 25779362
    • Choi Y, Kim TY, Oh DY, Lee KH, Han SW, Im SA, Kim TY, Bang YJ. The Impact of Diabetes Mellitus and Metformin Treatment on Survival of Patients with Advanced Pancreatic Cancer Undergoing Chemotherapy. Cancer Res Treat 2016; 48: 171-179 [PMID: 25779362 DOI: 10.4143/crt.2014.292]
    • (2016) Cancer Res Treat , vol.48 , pp. 171-179
    • Choi, Y.1    Kim, T.Y.2    Oh, D.Y.3    Lee, K.H.4    Han, S.W.5    Im, S.A.6    Kim, T.Y.7    Bang, Y.J.8
  • 113
  • 114
    • 84861576077 scopus 로고    scopus 로고
    • The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
    • PMID: 21913184
    • Lee JH, Kim TI, Jeon SM, Hong SP, Cheon JH, Kim WH. The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus. Int J Cancer 2012; 131: 752-759 [PMID: 21913184 DOI: 10.1002/ijc.26421]
    • (2012) J Cancer , vol.131 , pp. 752-759
    • Lee, J.H.1    Kim, T.I.2    Jeon, S.M.3    Hong, S.P.4    Cheon, J.H.5    Kim, W.H.6
  • 115
  • 122
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • PMID: 14511394
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2: 28 [PMID: 14511394 DOI: 10.1186/1475-4924-2-28]
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Mäkelä, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 124
    • 0037276069 scopus 로고    scopus 로고
    • A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
    • PMID: 12558800
    • Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K, Kemp BE, Witters LA, Mimura O, Yonezawa K. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 2003; 8: 65-79 [PMID: 12558800 DOI: 10.1046/j.1365-2443.2003.00615.x]
    • (2003) Genes Cells , vol.8 , pp. 65-79
    • Kimura, N.1    Tokunaga, C.2    Dalal, S.3    Richardson, C.4    Yoshino, K.5    Hara, K.6    Kemp, B.E.7    Witters, L.A.8    Mimura, O.9    Yonezawa, K.10
  • 125
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • PMID: 14651849
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-590 [PMID: 14651849 DOI: 10.1016/S0092-8674(03)00929-2]
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 126
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • PMID: 16308421
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310: 1642-1646 [PMID: 16308421 DOI: 10.1126/science.1120781]
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 127
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • PMID: 20577053
    • Foretz M, Hébrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010; 120: 2355-2369 [PMID: 20577053 DOI: 10.1172/JCI40671]
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hébrard, S.2    Leclerc, J.3    Zarrinpashneh, E.4    Soty, M.5    Mithieux, G.6    Sakamoto, K.7    Andreelli, F.8    Viollet, B.9
  • 128
    • 0034947869 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
    • PMID: 11438661
    • Takano A, Usui I, Haruta T, Kawahara J, Uno T, Iwata M, Kobayashi M. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 2001; 21: 5050-5062 [PMID: 11438661 DOI: 10.1128/MCB.21.15.5050-5062.2001]
    • (2001) Mol Cell Biol , vol.21 , pp. 5050-5062
    • Takano, A.1    Usui, I.2    Haruta, T.3    Kawahara, J.4    Uno, T.5    Iwata, M.6    Kobayashi, M.7
  • 129
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • PMID: 17882277
    • Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7: 763-777 [PMID: 17882277 DOI: 10.1038/nrc2222]
    • (2007) Nat Rev Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 130
    • 84892484894 scopus 로고    scopus 로고
    • Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells
    • PMID: 24482631
    • Cantoria MJ, Boros LG, Meuillet EJ. Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells. Metabolomics 2014; 10: 91-104 [PMID: 24482631 DOI: 10.1007/s11306-013-0555-4]
    • (2014) Metabolomics , vol.10 , pp. 91-104
    • Cantoria, M.J.1    Boros, L.G.2    Meuillet, E.J.3
  • 131
    • 84885078113 scopus 로고    scopus 로고
    • Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo
    • PMID: 24008375
    • Cai X, Hu X, Cai B, Wang Q, Li Y, Tan X, Hu H, Chen X, Huang J, Cheng J, Jing X. Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo. Oncol Rep 2013; 30: 2449-2457 [PMID: 24008375 DOI: 10.3892/or.2013.2718]
    • (2013) Oncol Rep , vol.30 , pp. 2449-2457
    • Cai, X.1    Hu, X.2    Cai, B.3    Wang, Q.4    Li, Y.5    Tan, X.6    Hu, H.7    Chen, X.8    Huang, J.9    Cheng, J.10    Jing, X.11
  • 132
    • 84941287211 scopus 로고    scopus 로고
    • Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas in Vitro and in Vivo
    • PMID: 26196392
    • Cai X, Hu X, Tan X, Cheng W, Wang Q, Chen X, Guan Y, Chen C, Jing X. Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo. PLoS One 2015; 10: e0133349 [PMID: 26196392 DOI: 10.1371/journal.pone.0133349]
    • (2015) PLoS One , vol.10 , pp. e0133349
    • Cai, X.1    Hu, X.2    Tan, X.3    Cheng, W.4    Wang, Q.5    Chen, X.6    Guan, Y.7    Chen, C.8    Jing, X.9
  • 135
    • 44849099894 scopus 로고    scopus 로고
    • The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
    • PMID: 18212742
    • Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27: 3576-3586 [PMID: 18212742 DOI: 10.1038/sj.onc.1211024]
    • (2008) Oncogene , vol.27 , pp. 3576-3586
    • Ben, S.I.1    Laurent, K.2    Loubat, A.3    Giorgetti-Peraldi, S.4    Colosetti, P.5    Auberger, P.6    Tanti, J.F.7    Le Marchand-Brustel, Y.8    Bost, F.9
  • 137
    • 84896776849 scopus 로고    scopus 로고
    • Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
    • PMID: 24577086
    • Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin W, Ke J, Huang J, Yeung SC, Zhang H. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell Death Dis 2014; 5: e1088 [PMID: 24577086 DOI: 10.1038/cddis.2014.59]
    • (2014) Cell Death Dis , vol.5 , pp. e1088
    • Feng, Y.1    Ke, C.2    Tang, Q.3    Dong, H.4    Zheng, X.5    Lin, W.6    Ke, J.7    Huang, J.8    Yeung, S.C.9    Zhang, H.10
  • 139
    • 84921614011 scopus 로고    scopus 로고
    • MiRNA in hepatocellular carcinoma
    • PMID: 25040738
    • Morishita A, Masaki T. miRNA in hepatocellular carcinoma. Hepatol Res 2015; 45: 128-141 [PMID: 25040738 DOI: 10.1111/hepr.12386]
    • (2015) Hepatol Res , vol.45 , pp. 128-141
    • Morishita, A.1    Masaki, T.2
  • 145
    • 84955462884 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin
    • PMID: 26708419
    • Kato K, Iwama H, Yamashita T, Kobayashi K, Fujihara S, Fujimori T, Kamada H, Kobara H, Masaki T. The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin. Oncol Rep 2016; 35: 1582-1592 [PMID: 26708419 DOI: 10.3892/or.2015.4496]
    • (2016) Oncol Rep , vol.35 , pp. 1582-1592
    • Kato, K.1    Iwama, H.2    Yamashita, T.3    Kobayashi, K.4    Fujihara, S.5    Fujimori, T.6    Kamada, H.7    Kobara, H.8    Masaki, T.9
  • 147
    • 84879607251 scopus 로고    scopus 로고
    • MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma
    • PMID: 23401231
    • Yang H, Fang F, Chang R, Yang L. MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. Hepatology 2013; 58: 205-217 [PMID: 23401231 DOI: 10.1002/hep.26315]
    • (2013) Hepatology , vol.58 , pp. 205-217
    • Yang, H.1    Fang, F.2    Chang, R.3    Yang, L.4
  • 150
    • 84862777219 scopus 로고    scopus 로고
    • Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells
    • PMID: 22245693
    • Li W, Yuan Y, Huang L, Qiao M, Zhang Y. Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells. Diabetes Res Clin Pract 2012; 96: 187-195 [PMID: 22245693 DOI: 10.1016/j.diabres.2011.12.028]
    • (2012) Diabetes Res Clin Pract , vol.96 , pp. 187-195
    • Li, W.1    Yuan, Y.2    Huang, L.3    Qiao, M.4    Zhang, Y.5
  • 151
    • 85015504020 scopus 로고    scopus 로고
    • MicroRNAs and cancer metabolism reprogramming: The paradigm of metformin
    • PMID: 25333033
    • Pulito C, Donzelli S, Muti P, Puzzo L, Strano S, Blandino G. microRNAs and cancer metabolism reprogramming: the paradigm of metformin. Ann Transl Med 2014; 2: 58 [PMID: 25333033 DOI: 10.3978/j.issn.2305-5839.2014.06.03]
    • (2014) Ann Transl Med , vol.2 , pp. 58
    • Pulito, C.1    Donzelli, S.2    Muti, P.3    Puzzo, L.4    Strano, S.5    Blandino, G.6
  • 152
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • PMID: 11689955
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111 [PMID: 11689955 DOI: 10.1038/35102167]
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 153
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • PMID: 18784658
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-768 [PMID: 18784658 DOI: 10.1038/nrc2499]
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 154
    • 45549084904 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • PMID: 18539957
    • Sell S, Leffert HL. Liver cancer stem cells. J Clin Oncol 2008; 26: 2800-2805 [PMID: 18539957 DOI: 10.1200/JCO.2007.15.5945]
    • (2008) J Clin Oncol , vol.26 , pp. 2800-2805
    • Sell, S.1    Leffert, H.L.2
  • 155
    • 45549096766 scopus 로고    scopus 로고
    • Cancer stem cells: A step toward the cure
    • PMID: 18539956
    • Boman BM, Wicha MS. Cancer stem cells: a step toward the cure. J Clin Oncol 2008; 26: 2795-2799 [PMID: 18539956 DOI: 10.1200/JCO.2008.17.7436]
    • (2008) J Clin Oncol , vol.26 , pp. 2795-2799
    • Boman, B.M.1    Wicha, M.S.2
  • 157
    • 84947461013 scopus 로고    scopus 로고
    • Research progress and prospects of markers for liver cancer stem cells
    • PMID: 26576103
    • Zhu CP, Wang AQ, Zhang HH, Wan XS, Yang XB, Chen SG, Zhao HT. Research progress and prospects of markers for liver cancer stem cells. World J Gastroenterol 2015; 21: 12190-12196 [PMID: 26576103 DOI: 10.3748/wjg.v21.i42.12190]
    • (2015) World J Gastroenterol , vol.21 , pp. 12190-12196
    • Zhu, C.P.1    Wang, A.Q.2    Zhang, H.H.3    Wan, X.S.4    Yang, X.B.5    Chen, S.G.6    Zhao, H.T.7
  • 158
    • 84959304460 scopus 로고    scopus 로고
    • Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology
    • PMID: 26123821
    • Chiba T, Iwama A, Yokosuka O. Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology. Hepatol Res 2016; 46: 50-57 [PMID: 26123821 DOI: 10.1111/hepr.12548]
    • (2016) Hepatol Res , vol.46 , pp. 50-57
    • Chiba, T.1    Iwama, A.2    Yokosuka, O.3
  • 159
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • PMID: 19752085
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009; 69: 7507-7511 [PMID: 19752085 DOI: 10.1158/0008-5472.CAN-09-2994]
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 161
    • 84911999849 scopus 로고    scopus 로고
    • Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes
    • PMID: 24798175
    • Zhang X, Harmsen WS, Mettler TA, Kim WR, Roberts RO, Therneau TM, Roberts LR, Chaiteerakij R. Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology 2014; 60: 2008-2016 [PMID: 24798175 DOI: 10.1002/hep.27199]
    • (2014) Hepatology , vol.60 , pp. 2008-2016
    • Zhang, X.1    Harmsen, W.S.2    Mettler, T.A.3    Kim, W.R.4    Roberts, R.O.5    Therneau, T.M.6    Roberts, L.R.7    Chaiteerakij, R.8
  • 162
    • 77950868733 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
    • PMID: 20393934
    • Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2010; (4): CD002967 [PMID: 20393934 DOI: 10.1001/archinte.163.21.2594]
    • (2010) Cochrane Database Syst Rev , Issue.4 , pp. CD002967
    • Salpeter, S.R.1    Greyber, E.2    Pasternak, G.A.3    Salpeter, E.E.4
  • 164
    • 0026619814 scopus 로고
    • Post-challenge glucose concentration, impaired glucose tolerance, diabetes, and cancer mortality in men
    • PMID: 1462971
    • Smith GD, Egger M, Shipley MJ, Marmot MG. Post-challenge glucose concentration, impaired glucose tolerance, diabetes, and cancer mortality in men. Am J Epidemiol 1992; 136: 1110-1114 [PMID: 1462971]
    • (1992) Am J Epidemiol , vol.136 , pp. 1110-1114
    • Smith, G.D.1    Egger, M.2    Shipley, M.J.3    Marmot, M.G.4
  • 165
    • 0030768876 scopus 로고    scopus 로고
    • Diabetes mellitus and the risk of primary liver cancer
    • PMID: 9335443
    • La Vecchia C, Negri E, Decarli A, Franceschi S. Diabetes mellitus and the risk of primary liver cancer. Int J Cancer 1997; 73: 204-207 [PMID: 9335443]
    • (1997) J Cancer , vol.73 , pp. 204-207
    • La Vecchia, C.1    Negri, E.2    Decarli, A.3    Franceschi, S.4
  • 166
    • 79960147420 scopus 로고    scopus 로고
    • Cancer incidence in type 2 diabetes patients-First results from a feasibility study of the D2C cohort
    • PMID: 21752291
    • Hense HW, Kajüter H, Wellmann J, Batzler WU. Cancer incidence in type 2 diabetes patients-first results from a feasibility study of the D2C cohort. Diabetol Metab Syndr 2011; 3: 15 [PMID: 21752291 DOI: 10.1186/1758-5996-3-15]
    • (2011) Diabetol Metab Syndr , vol.3 , pp. 15
    • Hense, H.W.1    Kajüter, H.2    Wellmann, J.3    Batzler, W.U.4
  • 167
    • 84863010936 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of hepatocellular carcinoma: A systematic review and meta-analysis
    • PMID: 21898753
    • Wang P, Kang D, Cao W, Wang Y, Liu Z. Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis. Diabetes Metab Res Rev 2012; 28: 109-122 [PMID: 21898753 DOI: 10.1002/dmrr.1291]
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 109-122
    • Wang, P.1    Kang, D.2    Cao, W.3    Wang, Y.4    Liu, Z.5
  • 168
    • 79961218135 scopus 로고    scopus 로고
    • Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta-analysis of cohort studies
    • PMID: 21544812
    • Wang C, Wang X, Gong G, Ben Q, Qiu W, Chen Y, Li G, Wang L. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer 2012; 130: 1639-1648 [PMID: 21544812 DOI: 10.1002/ijc.26165]
    • (2012) J Cancer , vol.130 , pp. 1639-1648
    • Wang, C.1    Wang, X.2    Gong, G.3    Ben, Q.4    Qiu, W.5    Chen, Y.6    Li, G.7    Wang, L.8
  • 169
    • 84901301642 scopus 로고    scopus 로고
    • Diabetes mellitus and poorer prognosis in hepatocellular carcinoma: A systematic review and meta-analysis
    • PMID: 24830459
    • Wang YG, Wang P, Wang B, Fu ZJ, Zhao WJ, Yan SL. Diabetes mellitus and poorer prognosis in hepatocellular carcinoma: a systematic review and meta-analysis. PLoS One 2014; 9: e95485 [PMID: 24830459 DOI: 10.1371/journal.pone.0095485]
    • (2014) PLoS One , vol.9 , pp. e95485
    • Wang, Y.G.1    Wang, P.2    Wang, B.3    Fu, Z.J.4    Zhao, W.J.5    Yan, S.L.6


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