메뉴 건너뛰기




Volumn 46, Issue 1, 2016, Pages 50-57

Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology

Author keywords

Cancer stem cell; Hepatocellular carcinoma; Polycomb group gene product; Stem cell biology; Tumor initiating cell

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; DISULFIRAM; EPITHELIAL CELL ADHESION MOLECULE; ISOCITRATE DEHYDROGENASE; METFORMIN; MICRORNA; PTC 209; SAL LIKE PROTEIN 4; SALAZOSULFAPYRIDINE; THY 1 ANTIGEN; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT; ZEBULARINE; ZINC FINGER PROTEIN;

EID: 84959304460     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12548     Document Type: Review
Times cited : (54)

References (75)
  • 1
    • 84867878045 scopus 로고    scopus 로고
    • Cancer stem cell definitions and terminology: the devil is in the details
    • Valent P, Bonnet D, De Maria R, etal. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer 2012; 12: 767-75.
    • (2012) Nat Rev Cancer , vol.12 , pp. 767-775
    • Valent, P.1    Bonnet, D.2    De Maria, R.3
  • 3
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 4
    • 4644306516 scopus 로고    scopus 로고
    • A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    • Hirschmann-Jax C, Foster AE, Wulf GG, etal. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 2004; 101: 14228-33.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14228-14233
    • Hirschmann-Jax, C.1    Foster, A.E.2    Wulf, G.G.3
  • 5
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • Chiba T, Kita K, Zheng YW, etal. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006; 44: 240-51.
    • (2006) Hepatology , vol.44 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.W.3
  • 6
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, etal. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1: 555-67.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 7
    • 84855655864 scopus 로고    scopus 로고
    • Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice
    • Dollé L, Best J, Empsen C, etal. Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice. Hepatology 2012; 55: 540-52.
    • (2012) Hepatology , vol.55 , pp. 540-552
    • Dollé, L.1    Best, J.2    Empsen, C.3
  • 8
    • 51649119918 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    • Ma S, Chan KW, Lee TK, etal. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 2008; 6: 1146-53.
    • (2008) Mol Cancer Res , vol.6 , pp. 1146-1153
    • Ma, S.1    Chan, K.W.2    Lee, T.K.3
  • 9
    • 84879603091 scopus 로고    scopus 로고
    • Visualization of stem cell features in human hepatocellular carcinoma reveals in vivo significance of tumor-host interaction and clinical course
    • Muramatsu S, Tanaka S, Mogushi K, etal. Visualization of stem cell features in human hepatocellular carcinoma reveals in vivo significance of tumor-host interaction and clinical course. Hepatology 2013; 58: 218-28.
    • (2013) Hepatology , vol.58 , pp. 218-228
    • Muramatsu, S.1    Tanaka, S.2    Mogushi, K.3
  • 10
    • 33750809196 scopus 로고    scopus 로고
    • Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
    • Suetsugu A, Nagaki M, Aoki H, etal. Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells. Biochem Biophys Res Commun 2006; 351: 820-4.
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 820-824
    • Suetsugu, A.1    Nagaki, M.2    Aoki, H.3
  • 11
    • 49249122615 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells
    • Yang W, Yan HX, Chen L, etal. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res 2008; 68: 4287-95.
    • (2008) Cancer Res , vol.68 , pp. 4287-4295
    • Yang, W.1    Yan, H.X.2    Chen, L.3
  • 12
    • 40949160140 scopus 로고    scopus 로고
    • Identification of local and circulating cancer stem cells in human liver cancer
    • Yang ZF, Ngai P, Ho DW, etal. Identification of local and circulating cancer stem cells in human liver cancer. Hepatology 2008; 47: 919-28.
    • (2008) Hepatology , vol.47 , pp. 919-928
    • Yang, Z.F.1    Ngai, P.2    Ho, D.W.3
  • 13
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, etal. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009; 136: 1012-24.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 14
    • 77949891635 scopus 로고    scopus 로고
    • Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma
    • Zhu Z, Hao X, Yan M, etal. Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer 2010; 126: 2067-78.
    • (2010) Int J Cancer , vol.126 , pp. 2067-2078
    • Zhu, Z.1    Hao, X.2    Yan, M.3
  • 15
    • 77956388547 scopus 로고    scopus 로고
    • CD13 is a therapeutic target in human liver cancer stem cells
    • Haraguchi N, Ishii H, Mimori K, etal. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest 2010; 120: 3326-39.
    • (2010) J Clin Invest , vol.120 , pp. 3326-3339
    • Haraguchi, N.1    Ishii, H.2    Mimori, K.3
  • 16
    • 79960006754 scopus 로고    scopus 로고
    • CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation
    • Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell 2011; 9: 50-63.
    • (2011) Cell Stem Cell , vol.9 , pp. 50-63
    • Lee, T.K.1    Castilho, A.2    Cheung, V.C.3    Tang, K.H.4    Ma, S.5    Ng, I.O.6
  • 17
    • 84903318466 scopus 로고    scopus 로고
    • Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma
    • Lee TK, Cheung VC, Lu P, etal. Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma. Hepatology 2014; 60: 179-91.
    • (2014) Hepatology , vol.60 , pp. 179-191
    • Lee, T.K.1    Cheung, V.C.2    Lu, P.3
  • 18
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194: 23-8.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 19
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso A, Dick JE. Evolution of the cancer stem cell model. Cell Stem Cell 2014; 14: 275-91.
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 20
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, etal. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-92.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 21
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, etal. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467: 1114-7.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 22
    • 84876098953 scopus 로고    scopus 로고
    • Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma
    • Yamashita T, Honda M, Nakamoto Y, etal. Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma. Hepatology 2013; 57: 1484-97.
    • (2013) Hepatology , vol.57 , pp. 1484-1497
    • Yamashita, T.1    Honda, M.2    Nakamoto, Y.3
  • 23
    • 2942691389 scopus 로고    scopus 로고
    • Stem cell origin of cancer and differentiation therapy
    • Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 2004; 51: 1-28.
    • (2004) Crit Rev Oncol Hematol , vol.51 , pp. 1-28
    • Sell, S.1
  • 24
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • Yamashita T, Forgues M, Wang W, etal. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 2008; 68: 1451-61.
    • (2008) Cancer Res , vol.68 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3
  • 25
    • 34548471937 scopus 로고    scopus 로고
    • Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation
    • Chiba T, Zheng YW, Kita K, etal. Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology 2007; 133: 937-50.
    • (2007) Gastroenterology , vol.133 , pp. 937-950
    • Chiba, T.1    Zheng, Y.W.2    Kita, K.3
  • 26
    • 0036096420 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: diagnosis and treatment
    • Befeler AS, Di Bisceglie AM. Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 2002; 122: 1609-19.
    • (2002) Gastroenterology , vol.122 , pp. 1609-1619
    • Befeler, A.S.1    Di Bisceglie, A.M.2
  • 27
    • 71749118560 scopus 로고    scopus 로고
    • Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective
    • Chiba T, Kamiya A, Yokosuka O, Iwama A. Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective. Cancer Lett 2009; 286: 145-53.
    • (2009) Cancer Lett , vol.286 , pp. 145-153
    • Chiba, T.1    Kamiya, A.2    Yokosuka, O.3    Iwama, A.4
  • 29
    • 77954910364 scopus 로고    scopus 로고
    • Role of the polycomb group proteins in hematopoietic stem cells
    • Konuma T, Oguro H, Iwama A. Role of the polycomb group proteins in hematopoietic stem cells. Dev Growth Differ 2010; 52: 505-16.
    • (2010) Dev Growth Differ , vol.52 , pp. 505-516
    • Konuma, T.1    Oguro, H.2    Iwama, A.3
  • 30
    • 77956222562 scopus 로고    scopus 로고
    • Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer
    • Sauvageau M, Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010; 7: 299-313.
    • (2010) Cell Stem Cell , vol.7 , pp. 299-313
    • Sauvageau, M.1    Sauvageau, G.2
  • 31
    • 54249132606 scopus 로고    scopus 로고
    • The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma
    • Chiba T, Miyagi S, Saraya A, etal. The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res 2008; 68: 7742-9.
    • (2008) Cancer Res , vol.68 , pp. 7742-7749
    • Chiba, T.1    Miyagi, S.2    Saraya, A.3
  • 32
    • 77952430646 scopus 로고    scopus 로고
    • The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells
    • Aoki R, Chiba T, Miyagi S, etal. The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells. J Hepatol 2010; 52: 854-63.
    • (2010) J Hepatol , vol.52 , pp. 854-863
    • Aoki, R.1    Chiba, T.2    Miyagi, S.3
  • 33
    • 84859157028 scopus 로고    scopus 로고
    • 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells
    • Chiba T, Suzuki E, Negishi M, etal. 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells. Int J Cancer 2012; 130: 2557-67.
    • (2012) Int J Cancer , vol.130 , pp. 2557-2567
    • Chiba, T.1    Suzuki, E.2    Negishi, M.3
  • 35
    • 60449093350 scopus 로고    scopus 로고
    • Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    • Oikawa T, Kamiya A, Kakinuma S, etal. Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology 2009; 136: 1000-11.
    • (2009) Gastroenterology , vol.136 , pp. 1000-1011
    • Oikawa, T.1    Kamiya, A.2    Kakinuma, S.3
  • 36
    • 84876121571 scopus 로고    scopus 로고
    • Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers
    • Oikawa T, Kamiya A, Zeniya M, etal. Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology 2013; 57: 1469-83.
    • (2013) Hepatology , vol.57 , pp. 1469-1483
    • Oikawa, T.1    Kamiya, A.2    Zeniya, M.3
  • 37
    • 84878887042 scopus 로고    scopus 로고
    • Oncofetal gene SALL4 in aggressive hepatocellular carcinoma
    • Yong KJ, Gao C, Lim JS, etal. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med 2013; 368: 2266-76.
    • (2013) N Engl J Med , vol.368 , pp. 2266-2276
    • Yong, K.J.1    Gao, C.2    Lim, J.S.3
  • 38
    • 84890549194 scopus 로고    scopus 로고
    • The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma
    • Zeng SS, Yamashita T, Kondo M, etal. The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma. J Hepatol 2014; 60: 127-34.
    • (2014) J Hepatol , vol.60 , pp. 127-134
    • Zeng, S.S.1    Yamashita, T.2    Kondo, M.3
  • 39
    • 84902549483 scopus 로고    scopus 로고
    • SALL4 immunoreactivity predicts prognosis in Western hepatocellular carcinoma patients but is a rare event: a study of 236 cases
    • Liu TC, Vachharajani N, Chapman WC, Brunt EM. SALL4 immunoreactivity predicts prognosis in Western hepatocellular carcinoma patients but is a rare event: a study of 236 cases. Am J Surg Pathol 2014; 38: 966-72.
    • (2014) Am J Surg Pathol , vol.38 , pp. 966-972
    • Liu, T.C.1    Vachharajani, N.2    Chapman, W.C.3    Brunt, E.M.4
  • 40
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: from mechanism to therapy
    • Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012; 150: 12-27.
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 41
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358: 1148-59.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 42
    • 84922273765 scopus 로고    scopus 로고
    • Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma
    • Chiba T, Saito T, Yuki K, etal. Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. Int J Cancer 2015; 136: 289-98.
    • (2015) Int J Cancer , vol.136 , pp. 289-298
    • Chiba, T.1    Saito, T.2    Yuki, K.3
  • 43
    • 34548645031 scopus 로고    scopus 로고
    • Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
    • Kondo Y, Shen L, Suzuki S, etal. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res 2007; 37: 974-83.
    • (2007) Hepatol Res , vol.37 , pp. 974-983
    • Kondo, Y.1    Shen, L.2    Suzuki, S.3
  • 44
    • 79952366279 scopus 로고    scopus 로고
    • Metabolism unhinged: IDH mutations in cancer
    • Prensner JR, Chinnaiyan AM. Metabolism unhinged: IDH mutations in cancer. Nat Med 2011; 17: 291-3.
    • (2011) Nat Med , vol.17 , pp. 291-293
    • Prensner, J.R.1    Chinnaiyan, A.M.2
  • 45
    • 84907033777 scopus 로고    scopus 로고
    • Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
    • Saha SK, Parachoniak CA, Ghanta KS, etal. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature 2014; 513: 110-4.
    • (2014) Nature , vol.513 , pp. 110-114
    • Saha, S.K.1    Parachoniak, C.A.2    Ghanta, K.S.3
  • 46
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, Yamashita T, Budhu A, etal. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009; 50: 472-80.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3
  • 47
    • 78649681554 scopus 로고    scopus 로고
    • miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S, Tang KH, Chan YP, etal. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010; 7: 694-707.
    • (2010) Cell Stem Cell , vol.7 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3
  • 48
    • 44649107292 scopus 로고    scopus 로고
    • Mechanisms of Disease: cancer stem cells--targeting the evil twin
    • Trumpp A, Wiestler OD. Mechanisms of Disease: cancer stem cells--targeting the evil twin. Nat Clin Pract Oncol 2008; 5: 337-47.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 337-347
    • Trumpp, A.1    Wiestler, O.D.2
  • 49
    • 84891852738 scopus 로고    scopus 로고
    • Self-renewal as a therapeutic target in human colorectal cancer
    • Kreso A, van Galen P, Pedley NM, etal. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med 2014; 20: 29-36.
    • (2014) Nat Med , vol.20 , pp. 29-36
    • Kreso, A.1    van Galen, P.2    Pedley, N.M.3
  • 50
    • 73649102464 scopus 로고    scopus 로고
    • EZH2 is essential for glioblastoma cancer stem cell maintenance
    • Suvà ML, Riggi N, Janiszewska M, etal. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res 2009; 69: 9211-8.
    • (2009) Cancer Res , vol.69 , pp. 9211-9218
    • Suvà, M.L.1    Riggi, N.2    Janiszewska, M.3
  • 51
    • 84921000037 scopus 로고    scopus 로고
    • Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
    • Xu B, On DM, Ma A, etal. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 2015; 125: 346-57.
    • (2015) Blood , vol.125 , pp. 346-357
    • Xu, B.1    On, D.M.2    Ma, A.3
  • 52
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, etal. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-12.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3
  • 54
    • 84901428064 scopus 로고    scopus 로고
    • Epigenetic reprogramming modulates malignant properties of human liver cancer
    • Raggi C, Factor VM, Seo D, etal. Epigenetic reprogramming modulates malignant properties of human liver cancer. Hepatology 2014; 59: 2251-62.
    • (2014) Hepatology , vol.59 , pp. 2251-2262
    • Raggi, C.1    Factor, V.M.2    Seo, D.3
  • 55
    • 77953663505 scopus 로고    scopus 로고
    • Antibodies targeting cancer stem cells: a new paradigm in immunotherapy?
    • Deonarain MP, Kousparou CA, Epenetos AA. Antibodies targeting cancer stem cells: a new paradigm in immunotherapy? MAbs 2009; 1: 12-25.
    • (2009) MAbs , vol.1 , pp. 12-25
    • Deonarain, M.P.1    Kousparou, C.A.2    Epenetos, A.A.3
  • 56
    • 84896069457 scopus 로고    scopus 로고
    • EpCAM-targeted therapy for human hepatocellular carcinoma
    • Ogawa K, Tanaka S, Matsumura S, etal. EpCAM-targeted therapy for human hepatocellular carcinoma. Ann Surg Oncol 2014; 21: 1314-22.
    • (2014) Ann Surg Oncol , vol.21 , pp. 1314-1322
    • Ogawa, K.1    Tanaka, S.2    Matsumura, S.3
  • 57
    • 46349107401 scopus 로고    scopus 로고
    • CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers
    • Smith LM, Nesterova A, Ryan MC, etal. CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers. Br J Cancer 2008; 99: 100-9.
    • (2008) Br J Cancer , vol.99 , pp. 100-109
    • Smith, L.M.1    Nesterova, A.2    Ryan, M.C.3
  • 58
    • 56149088742 scopus 로고    scopus 로고
    • Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene
    • Yin C, Lin Y, Zhang X, etal. Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene. Hepatology 2008; 48: 1528-39.
    • (2008) Hepatology , vol.48 , pp. 1528-1539
    • Yin, C.1    Lin, Y.2    Zhang, X.3
  • 59
    • 77953155085 scopus 로고    scopus 로고
    • Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation
    • Yamashita T, Honda M, Nio K, etal. Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. Cancer Res 2010; 70: 4687-97.
    • (2010) Cancer Res , vol.70 , pp. 4687-4697
    • Yamashita, T.1    Honda, M.2    Nio, K.3
  • 60
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007; 7: 733-6.
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 61
    • 4944249117 scopus 로고    scopus 로고
    • Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, etal. Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099-109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 62
    • 79952250124 scopus 로고    scopus 로고
    • Glioma-initiating cells: a predominant role in microglia/macrophages tropism to glioma
    • Yi L, Xiao H, Xu M, etal. Glioma-initiating cells: a predominant role in microglia/macrophages tropism to glioma. J Neuroimmunol 2011; 232: 75-82.
    • (2011) J Neuroimmunol , vol.232 , pp. 75-82
    • Yi, L.1    Xiao, H.2    Xu, M.3
  • 64
    • 77955923866 scopus 로고    scopus 로고
    • Metformin: taking away the candy for cancer?
    • Jalving M, Gietema JA, Lefrandt JD, etal. Metformin: taking away the candy for cancer? Eur J Cancer 2010; 46: 2369-80.
    • (2010) Eur J Cancer , vol.46 , pp. 2369-2380
    • Jalving, M.1    Gietema, J.A.2    Lefrandt, J.D.3
  • 65
    • 84880842525 scopus 로고    scopus 로고
    • Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells
    • Saito T, Chiba T, Yuki K, etal. Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells. PLoS One 2013; 8: e70010.
    • (2013) PLoS One , vol.8
    • Saito, T.1    Chiba, T.2    Yuki, K.3
  • 66
    • 84881015181 scopus 로고    scopus 로고
    • The mTOR pathway in hepatic malignancies
    • Bhat M, Sonenberg N, Gores GJ. The mTOR pathway in hepatic malignancies. Hepatology 2013; 58: 810-8.
    • (2013) Hepatology , vol.58 , pp. 810-818
    • Bhat, M.1    Sonenberg, N.2    Gores, G.J.3
  • 67
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou J, Wulfkuhle J, Zhang H, etal. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A 2007; 104: 16158-63.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3
  • 68
    • 33751285781 scopus 로고    scopus 로고
    • Disulfiram, a clinically used antialcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
    • Chen D, Cui QC, Yang H, Dou QP. Disulfiram, a clinically used antialcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res 2009; 66: 10425-33.
    • (2009) Cancer Res , vol.66 , pp. 10425-10433
    • Chen, D.1    Cui, Q.C.2    Yang, H.3    Dou, Q.P.4
  • 69
    • 79951688311 scopus 로고    scopus 로고
    • Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome
    • Cvek B. Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome. Curr Cancer Drug Targets 2011; 11: 332-7.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 332-337
    • Cvek, B.1
  • 70
    • 79955805229 scopus 로고    scopus 로고
    • Disulfiram modulated ROS-MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties
    • Yip NC, Fombon IS, Liu P, etal. Disulfiram modulated ROS-MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br J Cancer 2011; 104: 1564-74.
    • (2011) Br J Cancer , vol.104 , pp. 1564-1574
    • Yip, N.C.1    Fombon, I.S.2    Liu, P.3
  • 71
    • 84898003500 scopus 로고    scopus 로고
    • Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners
    • Chiba T, Suzuki E, Yuki K, etal. Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners. PLoS One 2014; 9: e84807.
    • (2014) PLoS One , vol.9
    • Chiba, T.1    Suzuki, E.2    Yuki, K.3
  • 72
    • 84867897977 scopus 로고    scopus 로고
    • Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
    • Liu P, Brown S, Goktug T, etal. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br J Cancer 2012; 107: 1488-97.
    • (2012) Br J Cancer , vol.107 , pp. 1488-1497
    • Liu, P.1    Brown, S.2    Goktug, T.3
  • 73
    • 0026640364 scopus 로고
    • Sulfasalazine and 5-ASA compounds
    • Allgayer H. Sulfasalazine and 5-ASA compounds. Gastroenterol Clin North Am 1992; 21: 643-58.
    • (1992) Gastroenterol Clin North Am , vol.21 , pp. 643-658
    • Allgayer, H.1
  • 74
    • 84875454018 scopus 로고    scopus 로고
    • xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
    • Yoshikawa M, Tsuchihashi K, Ishimoto T, etal. xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. Cancer Res 2013; 73: 1855-66.
    • (2013) Cancer Res , vol.73 , pp. 1855-1866
    • Yoshikawa, M.1    Tsuchihashi, K.2    Ishimoto, T.3
  • 75
    • 0033962047 scopus 로고    scopus 로고
    • Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival
    • Endo K, Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J Hepatol 2000; 32: 78-84.
    • (2000) J Hepatol , vol.32 , pp. 78-84
    • Endo, K.1    Terada, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.