Metformin induced AMPK activation, G0/G1 phase cell cycle arrest and the inhibition of growth of Esophageal squamous cell carcinomas in vitro and in vivo

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Cai, Xianbin ^a   Hu, Xi ^a   Tan, Xiaojun ^b   Cheng, Weijie ^a   Wang, Qinjia ^a   Chen, Xiaofeng ^a   Guan, Yinghong ^a   Chen, Chong ^a   Jing, Xubin ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b Department of Internal Medicine Chancheng District Central Hospital ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PROTEIN P53; ANTIDIABETIC AGENT; CDKN1A PROTEIN, HUMAN; CDKN1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CARCINOMA, SQUAMOUS CELL; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; ESOPHAGEAL NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR VOLUME; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME ACTIVATION; ESOPHAGEAL NEOPLASMS; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; MICE, NUDE; RESTING PHASE, CELL CYCLE; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84941287211     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133349     Document Type: Article

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