-
2
-
-
84864465226
-
Clinical implications of cancer stem cell biology in hepatocellular carcinoma
-
Ji J, Wang XW, (2012) Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Semin Oncol 39: 461-472.
-
(2012)
Semin Oncol
, vol.39
, pp. 461-472
-
-
Ji, J.1
Wang, X.W.2
-
3
-
-
52549087785
-
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
-
Visvader JE, Lindeman GJ, (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 755-768
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
5
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1184.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1184
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
-
6
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD, (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
7
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker SL, Majumdar SR, Veugelers P, Johnson JA, (2006) Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258.
-
(2006)
Diabetes Care
, vol.29
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
8
-
-
77955923866
-
Metformin: taking away the candy for cancer?
-
Jalving M, Gietema JA, Lefrandt JD, de Jong S, Reyners AK, et al. (2010) Metformin: taking away the candy for cancer? Eur J Cancer 46: 2369-2380.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2369-2380
-
-
Jalving, M.1
Gietema, J.A.2
Lefrandt, J.D.3
de Jong, S.4
Reyners, A.K.5
-
9
-
-
15544382574
-
Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
-
Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB, (2005) Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 54: 533-539.
-
(2005)
Gut
, vol.54
, pp. 533-539
-
-
Davila, J.A.1
Morgan, R.O.2
Shaib, Y.3
McGlynn, K.A.4
El-Serag, H.B.5
-
10
-
-
77954365681
-
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease
-
Donadon V, Balbi M, Mas MD, Casarin P, Zanette G, (2010) Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int 30: 750-758.
-
(2010)
Liver Int
, vol.30
, pp. 750-758
-
-
Donadon, V.1
Balbi, M.2
Mas, M.D.3
Casarin, P.4
Zanette, G.5
-
11
-
-
79954478103
-
Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation
-
Chen TM, Lin CC, Huang PT, Wen CF, (2011) Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation. J Gastroenterol Hepatol 26: 858-865.
-
(2011)
J Gastroenterol Hepatol
, vol.26
, pp. 858-865
-
-
Chen, T.M.1
Lin, C.C.2
Huang, P.T.3
Wen, C.F.4
-
12
-
-
60449087921
-
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
-
Yamashita T, Ji J, Budhu A, Forgues M, Yang W, et al. (2009) EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136: 1012-1024.
-
(2009)
Gastroenterology
, vol.136
, pp. 1012-1024
-
-
Yamashita, T.1
Ji, J.2
Budhu, A.3
Forgues, M.4
Yang, W.5
-
13
-
-
34249980343
-
Identification and characterization of tumorigenic liver cancer stem/progenitor cells
-
Ma S, Chan KW, Hu L, Lee TK, Wo JY, et al. (2007) Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132: 2542-2556.
-
(2007)
Gastroenterology
, vol.132
, pp. 2542-2556
-
-
Ma, S.1
Chan, K.W.2
Hu, L.3
Lee, T.K.4
Wo, J.Y.5
-
14
-
-
84865131639
-
In vitro and in vivo antitumoral action of metformin on hepatocellular carcinoma
-
Qu Z, Zhang Y, Liao M, Chen Y, Zhao J, et al. (2012) In vitro and in vivo antitumoral action of metformin on hepatocellular carcinoma. Hepatol Res 42: 922-933.
-
(2012)
Hepatol Res
, vol.42
, pp. 922-933
-
-
Qu, Z.1
Zhang, Y.2
Liao, M.3
Chen, Y.4
Zhao, J.5
-
15
-
-
84867405520
-
Metformin targets ovarian cancer stem cells in vitro and in vivo
-
Shank JJ, Yang K, Ghannam J, Cabrera L, Johnston CJ, et al. (2012) Metformin targets ovarian cancer stem cells in vitro and in vivo. Gynecol Oncol 127: 390-397.
-
(2012)
Gynecol Oncol
, vol.127
, pp. 390-397
-
-
Shank, J.J.1
Yang, K.2
Ghannam, J.3
Cabrera, L.4
Johnston, C.J.5
-
16
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K, (2009) Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69: 7507-7511.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
17
-
-
33746565515
-
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
-
Gollob JA, Wilhelm S, Carter C, Kelley SL, (2006) Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol 33: 392-406.
-
(2006)
Semin Oncol
, vol.33
, pp. 392-406
-
-
Gollob, J.A.1
Wilhelm, S.2
Carter, C.3
Kelley, S.L.4
-
18
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, et al. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441: 475-482.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
-
19
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, et al. (2007) Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A 104: 16158-16163.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16158-16163
-
-
Zhou, J.1
Wulfkuhle, J.2
Zhang, H.3
Gu, P.4
Yang, Y.5
-
20
-
-
58549108859
-
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
-
Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, et al. (2009) The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A 106: 268-273.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 268-273
-
-
Dubrovska, A.1
Kim, S.2
Salamone, R.J.3
Walker, J.R.4
Maira, S.M.5
-
21
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
Villanueva A, Chiang DY, Newell P, Peix J, Thung S, et al. (2008) Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135: 1972-1983.
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
Peix, J.4
Thung, S.5
-
23
-
-
80555126830
-
Phase 1/2 study of everolimus in advanced hepatocellular carcinoma
-
Zhu AX, Abrams TA, Miksad R, Blaszkowsky LS, Meyerhardt JA, et al. (2011) Phase 1/2 study of everolimus in advanced hepatocellular carcinoma. Cancer 117: 5094-5102.
-
(2011)
Cancer
, vol.117
, pp. 5094-5102
-
-
Zhu, A.X.1
Abrams, T.A.2
Miksad, R.3
Blaszkowsky, L.S.4
Meyerhardt, J.A.5
-
24
-
-
77949484645
-
Rapamycin inhibits proliferation and migration of hepatoma cells in vitro
-
Shirouzu Y, Ryschich E, Salnikova O, Kerkadze V, Schmidt J, et al. (2010) Rapamycin inhibits proliferation and migration of hepatoma cells in vitro. J Surg Res 159: 705-713.
-
(2010)
J Surg Res
, vol.159
, pp. 705-713
-
-
Shirouzu, Y.1
Ryschich, E.2
Salnikova, O.3
Kerkadze, V.4
Schmidt, J.5
-
25
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
Villanueva A, Chiang DY, Newell P, Peix J, Thung S, et al. (2008) Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135: 1972-1983.
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
Peix, J.4
Thung, S.5
-
26
-
-
0346362997
-
Rapamycins: mechanism of action and cellular resistance
-
Huang S, Bjornsti MA, Houghton PJ, (2003) Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2: 222-232.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 222-232
-
-
Huang, S.1
Bjornsti, M.A.2
Houghton, P.J.3
-
27
-
-
58149354390
-
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
-
Zhuang Y, Miskimins WK, (2008) Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal 3: 18.
-
(2008)
J Mol Signal
, vol.3
, pp. 18
-
-
Zhuang, Y.1
Miskimins, W.K.2
-
28
-
-
84874660234
-
Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies
-
Chen HP, Shieh JJ, Chang CC, Chen TT, Lin JT, et al. (2013) Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut 62: 606-615.
-
(2013)
Gut
, vol.62
, pp. 606-615
-
-
Chen, H.P.1
Shieh, J.J.2
Chang, C.C.3
Chen, T.T.4
Lin, J.T.5
-
29
-
-
84872529696
-
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
-
Hirsch HA, Iliopoulos D, Struhl K, (2013) Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A 110: 972-977.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 972-977
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Struhl, K.3
-
30
-
-
84873707522
-
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
-
Miller RA, Chu Q, Xie J, Foretz, Viollet B, et al. (2013) Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 494: 256-260.
-
(2013)
Nature
, vol.494
, pp. 256-260
-
-
Miller, R.A.1
Chu, Q.2
Xie, J.3
Foretz, V.B.4
-
31
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, et al. (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10: 25-34.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
-
32
-
-
47949116252
-
SHARP Investigators Study Group, Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, et al. (2008) SHARP Investigators Study Group, Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359: 378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
-
33
-
-
34547803161
-
Human hepatic stem cells from fetal and postnatal donors
-
Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, et al. (2007) Human hepatic stem cells from fetal and postnatal donors. J Exp Med 204: 1973-1987.
-
(2007)
J Exp Med
, vol.204
, pp. 1973-1987
-
-
Schmelzer, E.1
Zhang, L.2
Bruce, A.3
Wauthier, E.4
Ludlow, J.5
|