메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6 RECEPTOR; LMOD1 PROTEIN; PLATELET DERIVED GROWTH FACTOR D; PROCOLLAGEN C PROTEINASE; PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; TCF21 PROTEIN, HUMAN; TRANSCRIPTION FACTOR AP 1;

EID: 84978091648     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12092     Document Type: Article
Times cited : (100)

References (70)
  • 1
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy, M. I. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet. 9, 356-369 (2008)
    • (2008) Nat. Rev. Genet , vol.9 , pp. 356-369
    • McCarthy, M.I.1
  • 2
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander, E. S. & Schork, N. J. Genetic dissection of complex traits. Science 265, 2037-2048 (1994)
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.S.1    Schork, N.J.2
  • 3
    • 84871969762 scopus 로고    scopus 로고
    • Large-scale association analysis identifies new risk loci for coronary artery disease
    • Deloukas, P. et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 45, 25-33 (2013)
    • (2013) Nat. Genet , vol.45 , pp. 25-33
    • Deloukas, P.1
  • 4
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338 (2011)
    • (2011) Nat. Genet , vol.43 , pp. 333-338
    • Schunkert, H.1
  • 5
    • 84942987885 scopus 로고    scopus 로고
    • A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
    • Nikpay, M. et al. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121-1130 (2015)
    • (2015) Nat. Genet , vol.47 , pp. 1121-1130
    • Nikpay, M.1
  • 6
    • 84905491435 scopus 로고    scopus 로고
    • Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease
    • Makinen, V. P. et al. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 10, e1004502 (2014)
    • (2014) PLoS Genet , vol.10 , pp. e1004502
    • Makinen, V.P.1
  • 7
    • 84933052819 scopus 로고    scopus 로고
    • Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease
    • Ghosh, S. et al. Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease. Arterioscler. Thrombo Vasc. Biol. 35, 1712-1722 (2015)
    • (2015) Arterioscler. Thrombo Vasc. Biol , vol.35 , pp. 1712-1722
    • Ghosh, S.1
  • 8
    • 84920804189 scopus 로고    scopus 로고
    • Approaches for establishing the function of regulatory genetic variants involved in disease
    • Knight, J. C. Approaches for establishing the function of regulatory genetic variants involved in disease. Genome Med. 6, 92 (2014)
    • (2014) Genome Med , vol.6 , pp. 92
    • Knight, J.C.1
  • 9
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    • Musunuru, K. et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466, 714-719 (2010)
    • (2010) Nature , vol.466 , pp. 714-719
    • Musunuru, K.1
  • 10
    • 84880779995 scopus 로고    scopus 로고
    • Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus
    • Miller, C. L. et al. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genet. 9, e1003652 (2013)
    • (2013) PLoS Genet , vol.9 , pp. e1003652
    • Miller, C.L.1
  • 11
    • 77949775636 scopus 로고    scopus 로고
    • Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
    • Visel, A. et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464, 409-412 (2010)
    • (2010) Nature , vol.464 , pp. 409-412
    • Visel, A.1
  • 12
    • 84862777063 scopus 로고    scopus 로고
    • Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
    • Schodel, J. et al. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat. Genet. 44, s421-s422 (2012)
    • (2012) Nat. Genet , vol.44 , pp. s421-s422
    • Schodel, J.1
  • 13
    • 84897855294 scopus 로고    scopus 로고
    • Obesity-associated variants within FTO form long-range functional connections with IRX3
    • Smemo, S. et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375 (2014)
    • (2014) Nature , vol.507 , pp. 371-375
    • Smemo, S.1
  • 14
    • 84885620722 scopus 로고    scopus 로고
    • An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
    • Bauer, D. E. et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 342, 253-257 (2013)
    • (2013) Science , vol.342 , pp. 253-257
    • Bauer, D.E.1
  • 16
    • 77950458649 scopus 로고    scopus 로고
    • Transcriptome genetics using second generation sequencing in a Caucasian population
    • Montgomery, S. B. et al. Transcriptome genetics using second generation sequencing in a Caucasian population. Nature 464, 773-777 (2010)
    • (2010) Nature , vol.464 , pp. 773-777
    • Montgomery, S.B.1
  • 17
    • 84871601885 scopus 로고    scopus 로고
    • Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression
    • Almlof, J. C. et al. Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression. PLoS ONE 7, e52260 (2012)
    • (2012) PLoS ONE , vol.7 , pp. e52260
    • Almlof, J.C.1
  • 18
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190-1195 (2012)
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1
  • 19
    • 77950833803 scopus 로고    scopus 로고
    • Variation in transcription factor binding among humans
    • Kasowski, M. et al. Variation in transcription factor binding among humans. Science 328, 232-235 (2010)
    • (2010) Science , vol.328 , pp. 232-235
    • Kasowski, M.1
  • 20
    • 77649086970 scopus 로고    scopus 로고
    • A map of open chromatin in human pancreatic islets
    • Gaulton, K. J. et al. A map of open chromatin in human pancreatic islets. Nat. Genet. 42, 255-259 (2010)
    • (2010) Nat. Genet , vol.42 , pp. 255-259
    • Gaulton, K.J.1
  • 21
    • 84887072795 scopus 로고    scopus 로고
    • Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
    • Parker, S. C. et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc. Natl Acad. Sci. USA 110, 17921-17926 (2013)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 17921-17926
    • Parker, S.C.1
  • 22
    • 84896742056 scopus 로고    scopus 로고
    • Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
    • Fairfax, B. P. et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 343, 1246949 (2014)
    • (2014) Science , vol.343 , pp. 1246949
    • Fairfax, B.P.1
  • 23
    • 84923342405 scopus 로고    scopus 로고
    • Genome-wide significant loci: How important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders
    • Bjorkegren, J. L., Kovacic, J. C., Dudley, J. T. & Schadt, E. E. Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J. Am. Coll. Cardiol. 65, 830-845 (2015)
    • (2015) J. Am. Coll. Cardiol , vol.65 , pp. 830-845
    • Bjorkegren, J.L.1    Kovacic, J.C.2    Dudley, J.T.3    Schadt, E.E.4
  • 24
    • 84857293493 scopus 로고    scopus 로고
    • Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease
    • Alexander, M. R. & Owens, G. K. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Ann. Rev. Physiol. 74, 13-40 (2012)
    • (2012) Ann. Rev. Physiol , vol.74 , pp. 13-40
    • Alexander, M.R.1    Owens, G.K.2
  • 25
    • 84930758301 scopus 로고    scopus 로고
    • KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
    • Shankman, L. S. et al. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat. Med. 21, 628-637 (2015)
    • (2015) Nat. Med , vol.21 , pp. 628-637
    • Shankman, L.S.1
  • 26
    • 84924365586 scopus 로고    scopus 로고
    • The genetic and mechanistic basis for variation in gene regulation
    • Pai, A. A., Pritchard, J. K. & Gilad, Y. The genetic and mechanistic basis for variation in gene regulation. PLoS Genet. 11, e1004857 (2015)
    • (2015) PLoS Genet , vol.11 , pp. e1004857
    • Pai, A.A.1    Pritchard, J.K.2    Gilad, Y.3
  • 27
    • 84857111200 scopus 로고    scopus 로고
    • DNase i sensitivity QTLs are a major determinant of human expression variation
    • Degner, J. F. et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482, 390-394 (2012)
    • (2012) Nature , vol.482 , pp. 390-394
    • Degner, J.F.1
  • 28
    • 84888877924 scopus 로고    scopus 로고
    • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin DNA-binding proteins and nucleosome position
    • Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y. & Greenleaf, W. J. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 10, 1213-1218 (2013)
    • (2013) Nat. Methods , vol.10 , pp. 1213-1218
    • Buenrostro, J.D.1    Giresi, P.G.2    Zaba, L.C.3    Chang, H.Y.4    Greenleaf, W.J.5
  • 29
    • 84861889354 scopus 로고    scopus 로고
    • Differential DNase i hypersensitivity reveals factor-dependent chromatin dynamics
    • He, H. H. et al. Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics. Genome Res. 22, 1015-1025 (2012)
    • (2012) Genome Res , vol.22 , pp. 1015-1025
    • He, H.H.1
  • 30
    • 3042588831 scopus 로고    scopus 로고
    • Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    • Owens, G. K., Kumar, M. S. & Wamhoff, B. R. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol. Rev. 84, 767-801 (2004)
    • (2004) Physiol. Rev , vol.84 , pp. 767-801
    • Owens, G.K.1    Kumar, M.S.2    Wamhoff, B.R.3
  • 31
    • 84862874415 scopus 로고    scopus 로고
    • Vascular smooth muscle cell phenotypic plasticity: Focus on chromatin remodelling
    • Spin, J. M., Maegdefessel, L. & Tsao, P. S. Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling. Cardiovasc. Res. 95, 147-155 (2012)
    • (2012) Cardiovasc. Res , vol.95 , pp. 147-155
    • Spin, J.M.1    Maegdefessel, L.2    Tsao, P.S.3
  • 32
    • 27644527760 scopus 로고    scopus 로고
    • EPCR Ser219Gly: Elevated sEPCR, prothrombin F1p2, risk for coronary heart disease, and increased sEPCR shedding in vitro
    • Ireland, H. et al. EPCR Ser219Gly: elevated sEPCR, prothrombin F1p2, risk for coronary heart disease, and increased sEPCR shedding in vitro. Atherosclerosis 183, 283-292 (2005)
    • (2005) Atherosclerosis , vol.183 , pp. 283-292
    • Ireland, H.1
  • 33
    • 84885346937 scopus 로고    scopus 로고
    • The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis
    • Lopez-Mejias, R. et al. The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis. Arthritis Res. Ther. 15, R152 (2013)
    • (2013) Arthritis Res. Ther , vol.15 , pp. R152
    • Lopez-Mejias, R.1
  • 34
    • 84928924946 scopus 로고    scopus 로고
    • Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms
    • del Rosario, R. C. et al. Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms. Nat. Methods 12, 458-464 (2015)
    • (2015) Nat. Methods , vol.12 , pp. 458-464
    • Del Rosario, R.C.1
  • 35
    • 84930789026 scopus 로고    scopus 로고
    • Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci
    • Sazonova, O. et al. Characterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci. PLoS Genet. 11, e1005202 (2015)
    • (2015) PLoS Genet , vol.11 , pp. e1005202
    • Sazonova, O.1
  • 36
    • 84946541115 scopus 로고    scopus 로고
    • Disproportionate contributions of select genomic compartments and cell types to genetic risk for coronary artery disease
    • Won, H. H. et al. Disproportionate contributions of select genomic compartments and cell types to genetic risk for coronary artery disease. PLoS Genet. 11, e1005622 (2015)
    • (2015) PLoS Genet , vol.11 , pp. e1005622
    • Won, H.H.1
  • 37
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012)
    • (2012) Nature , vol.489 , pp. 57-74
    • Project Consortium, E.1
  • 38
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Kundaje, A. et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317-330 (2015)
    • (2015) Nature , vol.518 , pp. 317-330
    • Kundaje, A.1
  • 39
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012)
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1
  • 40
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohns disease susceptibility loci
    • Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohns disease susceptibility loci. Nat. Genet. 42, 1118-1125 (2010)
    • (2010) Nat. Genet , vol.42 , pp. 1118-1125
    • Franke, A.1
  • 41
    • 34547623750 scopus 로고    scopus 로고
    • Genomewide association analysis of coronary artery disease
    • Samani, N. J. et al. Genomewide association analysis of coronary artery disease. N. Engl. J. Med. 357, 443-453 (2007)
    • (2007) N. Engl. J. Med , vol.357 , pp. 443-453
    • Samani, N.J.1
  • 42
    • 84893682691 scopus 로고    scopus 로고
    • The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function
    • Liu, F., Wang, X., Hu, G., Wang, Y. & Zhou, J. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. J. Biol. Chem. 289, 3308-3316 (2014)
    • (2014) J. Biol. Chem , vol.289 , pp. 3308-3316
    • Liu, F.1    Wang, X.2    Hu, G.3    Wang, Y.4    Zhou, J.5
  • 43
    • 79953221100 scopus 로고    scopus 로고
    • A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
    • Artery Disease (c4d) Genetics Consortium C.
    • Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43, 339-344 (2011)
    • (2011) Nat. Genet , vol.43 , pp. 339-344
  • 44
    • 84946197772 scopus 로고    scopus 로고
    • Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation
    • Gaidatzis, D., Burger, L., Florescu, M. & Stadler, M. B. Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation. Nat. Biotechnol. 33, 722-729 (2015)
    • (2015) Nat. Biotechnol , vol.33 , pp. 722-729
    • Gaidatzis, D.1    Burger, L.2    Florescu, M.3    Stadler, M.B.4
  • 45
    • 84897379124 scopus 로고    scopus 로고
    • Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation
    • Miller, C. L. et al. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet. 10, e1004263 (2014)
    • (2014) PLoS Genet , vol.10 , pp. e1004263
    • Miller, C.L.1
  • 46
    • 74249091032 scopus 로고    scopus 로고
    • Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) study
    • Hagg, S. et al. Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study. PLoS Genet. 5, e1000754 (2009)
    • (2009) PLoS Genet , vol.5 , pp. e1000754
    • Hagg, S.1
  • 47
    • 84864407698 scopus 로고    scopus 로고
    • Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
    • Lu, X. et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat. Genet. 44, 890-894 (2012)
    • (2012) Nat. Genet , vol.44 , pp. 890-894
    • Lu, X.1
  • 48
    • 0031980818 scopus 로고    scopus 로고
    • Capsulin: A novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs
    • Lu, J., Richardson, J. A. & Olson, E. N. Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs. Mech. Dev. 73, 23-32 (1998)
    • (1998) Mech. Dev , vol.73 , pp. 23-32
    • Lu, J.1    Richardson, J.A.2    Olson, E.N.3
  • 49
    • 0031966326 scopus 로고    scopus 로고
    • Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries
    • Hidai, H., Bardales, R., Goodwin, R., Quertermous, T. & Quertermous, E. E. Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries. Mech. Dev. 73, 33-43 (1998)
    • (1998) Mech. Dev , vol.73 , pp. 33-43
    • Hidai, H.1    Bardales, R.2    Goodwin, R.3    Quertermous, T.4    Quertermous, E.E.5
  • 50
    • 84864067904 scopus 로고    scopus 로고
    • Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardiumderived cells into smooth muscle in the developing heart
    • Braitsch, C. M., Combs, M. D., Quaggin, S. E. & Yutzey, K. E. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardiumderived cells into smooth muscle in the developing heart. Dev. Biol. 368, 345-357 (2012)
    • (2012) Dev. Biol , vol.368 , pp. 345-357
    • Braitsch, C.M.1    Combs, M.D.2    Quaggin, S.E.3    Yutzey, K.E.4
  • 51
    • 84930814579 scopus 로고    scopus 로고
    • Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
    • Nurnberg, S. T. et al. Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap. PLoS Genet. 11, e1005155 (2015)
    • (2015) PLoS Genet , vol.11 , pp. e1005155
    • Nurnberg, S.T.1
  • 52
    • 79959911826 scopus 로고    scopus 로고
    • Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
    • Biddie, S. C. et al. Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. Mol. Cell 43, 145-155 (2011)
    • (2011) Mol. Cell , vol.43 , pp. 145-155
    • Biddie, S.C.1
  • 53
    • 84892814234 scopus 로고    scopus 로고
    • Chromatin modifiers and remodellers: Regulators of cellular differentiation
    • Chen, T. & Dent, S. Y. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat. Rev. Genet. 15, 93-106 (2014)
    • (2014) Nat. Rev. Genet , vol.15 , pp. 93-106
    • Chen, T.1    Dent, S.Y.2
  • 54
    • 84923326765 scopus 로고    scopus 로고
    • Genetic and epigenetic fine mapping of causal autoimmune disease variants
    • Farh, K. K. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337-343 (2015)
    • (2015) Nature , vol.518 , pp. 337-343
    • Farh, K.K.1
  • 55
    • 84891697734 scopus 로고    scopus 로고
    • Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
    • Corradin, O. et al. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Genome Res. 24, 1-13 (2014)
    • (2014) Genome Res , vol.24 , pp. 1-13
    • Corradin, O.1
  • 56
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross, R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999)
    • (1999) N. Engl. J. Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 57
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore, K. J. & Tabas, I. Macrophages in the pathogenesis of atherosclerosis. Cell 145, 341-355 (2011)
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 58
    • 84910137512 scopus 로고    scopus 로고
    • Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis
    • Feil, S. et al. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ. Res. 115, 662-667 (2014)
    • (2014) Circ. Res , vol.115 , pp. 662-667
    • Feil, S.1
  • 59
    • 84896744423 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
    • Kojima, Y. et al. Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. J. Clin. Invest. 124, 1083-1097 (2014)
    • (2014) J. Clin. Invest , vol.124 , pp. 1083-1097
    • Kojima, Y.1
  • 60
    • 84873473857 scopus 로고    scopus 로고
    • Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study
    • Pechlivanis, S. et al. Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study. BMC Med. Genet. 14, 23 (2013)
    • (2013) BMC Med. Genet , vol.14 , pp. 23
    • Pechlivanis, S.1
  • 61
    • 0035826891 scopus 로고    scopus 로고
    • Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes
    • Uutela, M. et al. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes. Circulation 103, 2242-2247 (2001)
    • (2001) Circulation , vol.103 , pp. 2242-2247
    • Uutela, M.1
  • 62
    • 84937598288 scopus 로고    scopus 로고
    • PDGFRbeta signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis
    • He, C. et al. PDGFRbeta signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat. Commun. 6, 7770 (2015)
    • (2015) Nat. Commun , vol.6 , pp. 7770
    • He, C.1
  • 63
    • 84856078064 scopus 로고    scopus 로고
    • Leiomodin 1, a new serum response factordependent target gene expressed preferentially in differentiated smooth muscle cells
    • Nanda, V. & Miano, J. M. Leiomodin 1, a new serum response factordependent target gene expressed preferentially in differentiated smooth muscle cells. J. Biol. Chem. 287, 2459-2467 (2012)
    • (2012) J. Biol. Chem , vol.287 , pp. 2459-2467
    • Nanda, V.1    Miano, J.M.2
  • 64
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter, C. A. & Jones, S. A. IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16, 448-457 (2015)
    • (2015) Nat. Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 66
    • 84922061336 scopus 로고    scopus 로고
    • CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice-brief report
    • Han, Y., Slivano, O. J., Christie, C. K., Cheng, A. W. & Miano, J. M. CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice-brief report. Arterioscler. Thromb. Vasc. Biol. 35, 312-315 (2015)
    • (2015) Arterioscler. Thromb. Vasc. Biol , vol.35 , pp. 312-315
    • Han, Y.1    Slivano, O.J.2    Christie, C.K.3    Cheng, A.W.4    Miano, J.M.5
  • 67
    • 84944028847 scopus 로고    scopus 로고
    • Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability
    • Das, A. et al. Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability. Nat. Commun. 6, 8555 (2015)
    • (2015) Nat. Commun , vol.6 , pp. 8555
    • Das, A.1
  • 68
    • 84942242979 scopus 로고    scopus 로고
    • Prediction of Causal Candidate Genes in Coronary Artery Disease Loci
    • Braenne, I. et al. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler. Thromb. Vasc. Biol. 35, 2207-2217 (2015)
    • (2015) Arterioscler. Thromb. Vasc. Biol , vol.35 , pp. 2207-2217
    • Braenne, I.1
  • 69
    • 84942940566 scopus 로고    scopus 로고
    • Defining cell types and states with single-cell genomics
    • Trapnell, C. Defining cell types and states with single-cell genomics. Genome Res. 25, 1491-1498 (2015)
    • (2015) Genome Res , vol.25 , pp. 1491-1498
    • Trapnell, C.1
  • 70
    • 84865777819 scopus 로고    scopus 로고
    • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
    • Landt, S. G. et al. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 22, 1813-1831 (2012)
    • (2012) Genome Res , vol.22 , pp. 1813-1831
    • Landt, S.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.