Variation in transcription factor binding among humans

Science

Volumn 328, Issue 5975, 2010, Pages 232-235

  Kasowski, Maya ^a   Grubert, Fabian ^a,b   Heffelfinger, Christopher ^a   Hariharan, Manoj ^a,b   Asabere, Akwasi ^a   Waszak, Sebastian M ^c,d   Habegger, Lukas ^a   Rozowsky, Joel ^a   Shi, Minyi ^a,b   Urban, Alexander E ^a,e   Hong, Mi Young ^a   Karczewski, Konrad J ^b   Huber, Wolfgang ^c   Weissman, Sherman M ^e   Gerstein, Mark B ^a,f   Korbel, Jan O ^c,g   Snyder, Michael ^a,b  

^a YALE UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF APPLIED SCIENCES WEIHENSTEPHAN TRIESDORF   (Germany)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Yale University   (United States)

^g WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR;

CHROMOSOME; DIVERGENCE; GENE EXPRESSION; GENETIC VARIATION; GENOME; IMMUNE RESPONSE; POLYMORPHISM; PRIMATE;

ARTICLE; BINDING SITE; CHIMPANZEE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC VARIABILITY; GENOME; HUMAN; IMMUNE RESPONSE; LYMPHOBLASTOID CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BINDING SITES; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DNA COPY NUMBER VARIATIONS; DNA, INTERGENIC; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; PAN TROGLODYTES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; RNA POLYMERASE II; SEQUENCE ANALYSIS, DNA; SPECIES SPECIFICITY; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION INITIATION SITE;

PAN;

EID: 77950833803     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1183621     Document Type: Article

References (19)

1. B. E. Stranger et. al Science 315, 848 (2007).
2. M. V. Rockman, L. Kruglyak, Nat. Rev. Genet. 7, 862 (2006).
3. D. A. Skelly, J. Ronald, J. M. Akey, Annu. Rev. Genomics Hum. Genet. 10, 313 (2009).
4. A. R. Borneman et. al Science 317, 815 (2007).
5. International HapMap Consortium, Nature 449, 851 (2007).
6. More information on the 1000 Genomes project can be found at http://1000genomes.org.
7. J. O. Korbel et.al., Science 318,'420 (2007).
8. E. Tuzun et.al., Nat. Genet. 37, 727 (2005).
9. J. Rozowsky et.al., Nat. Biotechnol 27, 66 (2009).
10. Materials and methods and supporting data are available on Science Online.
11. O.H. Krämer et.al.,Genes Dev. 20, 473 (2006).
12. A. Sandelln, W. Alkema, P. Engström, W. W. Wasserman, B. Lenhard, Nucleic Adds Res. 32 (Database issue), D91 (2004).
13. M. C. Faniello et.al., J. Biol. Chem. 274, 7623 (1999).
14. J. M. Kidd et al., Nature 453, 56 (2008).
15. S. A. McCarroll et.al., Nat. Genet. 40, 1166 (2008).
16. H. Creely, P. Khaltovlch, Prog. Brain Res. 158, 295 (2006).
17. S. Levy et al. PLOS Biol. 5, e254 (2007).
18. H. Watanabe et.al., Nature 429, 382 (2004).
19. We thank the 1000 Genomes project for early data access. This research was funded by grants from NIH (M.S., S.W., and M.G.), and by funding from the European Molecular Biology Laboratory (J.K.), a March of Dimes Foundation Grant (A.U.), and the NIH Medical Scientist Training Program grant TG T32GM07205 (M.K.). M.K. was a Howard Hughes Medical Institute Medical Research Training Fellow. Data sets are available at the Gene Expression Omnibus (GEO) database with accession number GSE19486. M.S. is on the Scientific Advisory Board and a founder for both Affymetrix and Metagenomix.