Phenolic constituents from apple tree leaves and their in vitro biological activity

Industrial Crops and Products

Volumn 90, Issue , 2016, Pages 118-125

  Rana, Shalika ^a,b   Kumar, Shiv ^a,b   Rana, Ajay ^b   Sharma, Vivek ^c   Katoch, Preeti ^b   Padwad, Yogendra ^a,b   Bhushan, Shashi ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

^c CSK HIMACHAL PRADESH AGRICULTURAL UNIVERSITY   (India)

Author keywords

Antiinflammatory; Antimicrobial; Antioxidant; Apple leaves; Cytotoxicity; Phenolics

Indexed keywords

ANTIOXIDANTS; CELL CULTURE; CELL PROLIFERATION; CYTOTOXICITY; EXTRACTION; FLAVONOIDS; FRUITS; MICROORGANISMS; NITRIC OXIDE; PHENOLS; SOLVENT EXTRACTION;

ANTI-INFLAMMATORIES; ANTIMICROBIAL; ANTIMICROBIAL TESTING; APPLE LEAVES; LYMPHOCYTE PROLIFERATION; MALUS DOMESTICA BORKH; PHENOLICS; SCAVENGING ACTIVITIES;

BIOACTIVITY;

ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; BIOLOGICAL ANALYSIS; DECIDUOUS TREE; LEAF; PHENOLIC COMPOUND; PHYTOCHEMISTRY; SOLVENT; TOXICITY;

LONCHOCARPUS CAPASSA; MALUS X DOMESTICA;

EID: 84977665513     PISSN: 09266690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.indcrop.2016.06.027     Document Type: Article

References (38)

1. Alissa, E.M., Ferns, G.A., Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases. J. Nutr. Metab., 2012, 16 Article ID 569486.
2. Barreca, D., Bellocco, E., Lagana, G., Ginestra, G., Bisignano, C., Biochemical and antimicrobial activity of phloretin and its glycosilated derivatives present in apple and kumquat. Food Chem. 160 (2014), 292–297.
3. Bonarska-Kujawa, D., Cyboran, S., Oszmianski, J., Kleszczynska, H., Extracts from apple leaves and fruits as effective antioxidants. J. Med. Plant Res. 5 (2011), 2339–2347.
4. Chang, W.-T., Huang, W.-T., Liou, C.-J., Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. Food Chem. 134 (2012), 972–979.
5. Cohn, Z., The activation of mononuclear phagocytes: fact, fancy, and future. J. Immunol. 121 (1978), 813–816.
6. Dahmoune, F., Spigno, G., Moussi, K., Remini, H., Cherbal, H., Madani, K., Pistacia lentiscus leaves as a source of phenolic compounds: microwave-assisted extraction optimized and compared with ultrasound-assisted and conventional solvent extraction. Ind. Crops Prod. 61 (2014), 31–40.
7. Ding, A.H., Nathan, C.F., Stuehr, D.J., Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141 (1988), 2407–2412.
8. Fratianni, F., Coppola, R., Nazzaro, F., Phenolic composition and antimicrobial and antiquorum sensing activity of an ethanolic extract of peels from the apple cultivar Annurca. J. Med. Food. 14 (2011), 957–963.
9. George, T.W., Niwat, C., Waroonphan, S., Gordon, M.H., Lovegrove, J.A., Effects of chronic and acute consumption of fruit- and vegetable-puree- based drinks on vasodilation: risk factors for CVD and the response as a result of the eNOS G298T polymorphism. Proc. Nutr. Soc. 68 (2009), 148–161.
10. Kazan, A., Koyu, H., Turu, I.C., Yesil-Celiktas, O., Supercritical fluid extraction of Prunus persica leaves and utilization possibilities as a source of phenolic compounds. J. Supercrit. Fluids 92 (2014), 55–59.
11. Kosalec, I., Bakmaz, M., Pepeljnjak, S., Quantitative analysis of the flavonoid in raw propolis from northern Croatia. Acta Pharm. 54 (2004), 65–72.
12. Liaudanskas, M., Viskelis, P., Raudonis, R., Kviklys, D., Uselis, N., Janulis, V., Phenolic composition and antioxidant activity of Malus domestica leaves. Sci. World J., 306217, 2014, 10.
13. Lin, B.F., Chiang, B.L., Lin, J.Y., Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro. Int. Immunopharmacol. 5 (2005), 711–722.
14. Liu, R.H., Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am. J. Clin. Nutr. 78 (2003), 517S–520S.
15. M&M, 2014. http://www.marketsandmarkets.com/Market-Reports/phytochemical-plant-extract-market-268182066.html.
16. Mayr, U., Michalek, S., Treutter, D., Feucht, W., Phenolic compounds of apple and their relationship to scab resistance. J. Phytopathol. 145 (1997), 69–75.
17. Melguizo-Melguizo, D., Diaz-de-Cerio, E., Quirantes-Piné, R.J., Svarc-Gajić, A., Segura-Carretero, The potential of Artemisia vulgaris leaves as a source of antioxidant phenolic compounds. J. Funct. Foods. 10 (2014), 192–200.
18. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983), 55–63.
19. 2+ handling, the action potential, and ion currents in rat ventricular myocytes. J. Pharmacol. Exp. Ther. 321 (2007), 921–929.
20. Padwad, Y., Ganju, L., Jain, M., Chanda, S., Karan, D., Banerjee, P.K., Sawhney, R.C., Effect of leaf extract of Seabuckthorn on lipopolysaccharide induced inflammatory response in murine macrophages. Int. Immunopharmacol. 5 (2005), 46–52.
21. Pandey, K.B., Rizvi, S.I., Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev. 2 (2009), 270–278.
22. Park, A., Jeong, H.H., Lee, J., Lee, C.S., The inhibitory effect of phloretin on the formation of Escherichia coli O157:H7 biofilm in a microfluidic system. BioChip J. 6 (2012), 299–305.
23. Petkovsek, M.M., Stampar, F., Veberic, R., Increased phenolic content in apple leaves infected with the apple scab pathogen. J. Plant Pathol. 90 (2008), 49–55.
24. Petkovsek, M.M., Slatnar, A., Stampar, F., Veberic, R., The influence of organic/integrated production on the content of phenolic compounds in apple leaves and fruits in four different varieties over a 2-year period. J. Sci. Food Agric. 90 (2010), 2366–2378.
25. Petkovsek, M.M., Slatnar, A., Stampar, F., Veberic, R., Phenolic compounds in apple leaves after infection with apple scab. Biol. Plant. 55 (2011), 725–730.
26. Piccinelli, A., Dapena, E., Mangas, J.J., Polyphenolic pattern in apple tree leaves in relation to scab resistance: a preliminary study. J. Agric. Food Chem. 43 (1995), 2273–2278.
27. Rana, A., Bhangalia, S., Singh, H.P., A new phenylethanoid glucoside from Jacranda Mimosifolia. Nat. Prod. Res., 27, 2013, 1167.
28. Rana, S., Rana, A., Gulati, A., Bhushan, S., RP-HPLC-DAD determination of phenolics in industrial apple pomace. Food Anal. Methods 7 (2014), 1424–1432.
29. Ray, A., Dittel, B.N., Isolation of mouse peritoneal cavity cells. J. Vis. Exp. 35 (2010), 1–3.
30. Re, R., Pellegrini, N., Proteggente, A., Penal, A., Yang, M., Rice-Evans, C., Antioxidant activity applying an improved ABTS radical cation decolourisation assay. Free Radic. Bio. Med. 26 (1999), 1231–1237.
31. Rezik, B.M., Haenen, G.R., Vander, V.W.J., Bast, A., The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids. Biochem. Biophys. Res. Commun. 295 (2002), 9–13.
32. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J.T., Bokesch, H., Kenney, S., Boyd, M.R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82 (1990), 1107–1112.
33. Swain, T., Hillis, E., The Phenolic constituents of Prunus domestica. I. The quantitative analysis of phenolic constituents. J. Sci. Food Agric. 10 (1959), 63–68.
34. WHO Fact Sheet, The Top 10 Causes of Death. 2014, WHO.
35. Walia, M., Mann, T.S., Kumar, D., Agnihotri, V.K., Singh, B., Chemical composition and in vitro cytotoxic activity of essential oil of leaves of Malus domestica growing in Western Himalaya (India). Evid. Based Complement. Alternat. Med., 2012, 6 Article ID 649727.
36. Walia, M., Kumar, S., Agnihotria, V.K., UPLC-PDA quantification of chemical constituents of two different varieties (golden and royal) of apple leaves and their antioxidant activity. J. Sci. Food Agric., 2015, 10.1002/jsfa.7239.
37. Wiegand, I., Hilpert, K., Hancock, R.E., Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat. Protoc. 3 (2008), 163–175.
38. Wu, C.H., Ho, Y.S., Tsai, C.Y., Wang, Y.J., Tseng, H., Wei, P.L., Lee, C.H., Liu, R.S., Lin, S.Y., In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter. Int. J. Cancer 124 (2009), 2210–2219.