DHF-18, a new synthetic flavonoid, induced a mitochondrial-mediated apoptosis of hepatocarcinoma cells in vivo and in vitro

European Journal of Pharmacology

Volumn 651, Issue 1-3, 2011, Pages 33-40

  Zhang, Lin Bo ^a   Qiang, Lei ^a   Chen, Fei Hong ^a   Wu, Tian ^a   Rong, Jing Jing ^a   Zhao, Qing ^a   Zou, Mei Juan ^a   Yang, Zhen ^a   You, Qi Dong ^a   Li, Zhi Yu ^a   Wu, Yu Lin ^a   Guo, Qing Long ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase cascade; Flavonoid; Mitochondria

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOPHOSPHAMIDE; CYTOCHROME C; DHF 18; FLAVONOID; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL NUCLEUS; CELL STRAIN HEPG2; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; FLAVONES; FLAVONOIDS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MITOCHONDRIA; PIPERAZINES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650678550     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.067     Document Type: Article

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