Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca 2+ homeostasis

Cancer Research

Volumn 71, Issue 24, 2011, Pages 7659-7669

  Maddalena, Francesca ^a   Laudiero, Gabriella ^b   Piscazzi, Annamaria ^a   Secondo, Agnese ^b   Scorziello, Antonella ^b   Lombardi, Valentina ^a   Matassa, Danilo Swann ^b   Fersini, Alberto ^a   Neri, Vincenzo ^a   Esposito, Franca ^b   Landriscina, Matteo ^a,c  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c REFERRAL CANCER CENTER OF BASILICATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASPASE 12; CASPASE 3; FLUOROURACIL; GLUCOSE REGULATED PROTEIN 78; IRINOTECAN; OXALIPLATIN; SORCIN;

APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CANCER CELL; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG RESISTANCE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CALCIUM-BINDING PROTEINS; CASPASE 12; CASPASE 3; COLORECTAL NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HOMEOSTASIS; HT29 CELLS; HUMANS; IMMUNOBLOTTING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR WEIGHT; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UP-REGULATION;

EID: 84255192001     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-2172     Document Type: Article

References (47)

1. Wilson TR, Johnston PG, Longley DB. Anti-apoptotic mechanisms of drug resistance in cancer. Curr Cancer Drug Targets 2009;9:307-19.
2. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581-92. (Pubitemid 46359643)
3. Herszenyi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci 2010;14:249-58.
4. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, et al. Colorectal cancer. Lancet 2010;375:1030-47.
5. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 2007;131:257-70. (Pubitemid 47576138)
6. Landriscina M, Maddalena F, Laudiero G, Esposito F. Adaptation to oxidative stress, chemoresistance, and cell survival. Antioxid Redox Signal 2009;11:2701-16.
7. Montesano Gesualdi N, Chirico G, Pirozzi G, Costantino E, Landriscina M, Esposito F. Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress 2007;10:342-50. (Pubitemid 350125789)
8. Costantino E, Maddalena F, Calise S, Piscazzi A, Tirino V, Fersini A, et al. TRAP1, a novel mitochondrial chaperone responsible for multidrug resistance and protection from apoptotis in human colorectal carcinoma cells. Cancer Lett 2009;279:39-46.
9. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, et al. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol 2009;176:393-401.
10. Fang W, Li X, Jiang Q, Liu Z, Yang H, Wang S, et al. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med 2008;6:32.
11. Landriscina M, Laudiero G, Maddalena F, Amoroso MR, Piscazzi A, Cozzolino F, et al. Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. Cancer Res 2010;70:6577-86.
12. Meyers MB, Pickel VM, Sheu SS, Sharma VK, Scotto KW, Fishman GI. Association of sorcin with the cardiac ryanodine receptor. J Biol Chem 1995;270:26411-8.
13. Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, et al. Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels. J Biol Chem 1998;273:18930-5. (Pubitemid 28366281)
14. Zamparelli C, Macquaide N, Colotti G, Verzili D, Seidler T, Smith GL, et al. Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains. J Mol Cell Cardiol 2010;49:132-41.
15. Farrell EF, Antaramian A, Rueda A, Gomez AM, Valdivia HH. Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem 2003;278:34660-6. (Pubitemid 37553315)
16. Meyers MB, Fischer A, Sun YJ, Lopes CM, Rohacs T, Nakamura TY, et al. Sorcin regulates excitation-contraction coupling in the heart. J Biol Chem 2003;278:28865-71. (Pubitemid 36935797)
17. Wang SL, Tam MF, Ho YS, Pai SH, Kao MC. Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristineresistant HOB1 lymphoma cells. Biochim Biophys Acta 1995;1260:285-93.
18. Yang YX, Chen ZC, Zhang GY, Yi H, Xiao ZQ. A subcelluar proteomic investigation into vincristine-resistant gastric cancer cell line. J Cell Biochem 2008;104:1010-21. (Pubitemid 351830847)
19. Qu Y, Yang Y, Liu B, Xiao W. Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer. Med Oncol 2010;27:1303-8.
20. Maxwell SA, Cherry EM, Bayless KJ. Akt, 14-3-3zeta, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma. Leuk Lymphoma 2011;52:849-64.
21. Kawakami M, Nakamura T, Okamura N, Komoto C, Markova S, Kobayashi H, et al. Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells. Biol Pharm Bull 2007;30:1065-73. (Pubitemid 46883867)
22. He Q, Zhang G, Hou D, Leng A, Xu M, Peng J, et al. Overexpression of sorcin results in multidrug resistance in gastric cancer cells with upregulation of P-gp. Oncol Rep 2011;25:237-43.
23. Zhou Y, Xu Y, Tan Y, Qi J, Xiao Y, Yang C, et al. Sorcin, an important gene associated with multidrug-resistance in human leukemia cells. Leuk Res 2006;30:469-76. (Pubitemid 43254968)
24. Nagpal JK, Das BR. Identification of differentially expressed genes in tobacco chewing-mediated oral cancer by differential display-polymerase chain reaction. Eur J Clin Invest 2007;37:658-64. (Pubitemid 47063105)
25. Tan Y, Li G, Zhao C, Wang J, Zhao H, Xue Y, et al. Expression of sorcin predicts poor outcome in acute myeloid leukemia. Leuk Res 2003;27:125-31. (Pubitemid 36069079)
26. Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, et al. Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Res 2008;68:6324-30.
27. Barone C, Landriscina M, Quirino M, Basso M, Pozzo C, Schinzari G, et al. Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial. Br J Cancer 2007;96:21-8. (Pubitemid 46094634)
28. Hassink GC, Zhao B, Sompallae R, Altun M, Gastaldello S, Zinin NV, et al. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep 2009;10:755-61.
29. Secondo A, Molinaro P, Pannaccione A, Esposito A, Cantile M, Lippiello P, et al. Nitric oxide stimulates NCX1 and NCX2 but inhibits NCX3 isoform by three distinct molecular determinants. Mol Pharmacol 2011;79:558-68.
30. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-50. (Pubitemid 15114340)
31. Janczewski AM, Lakatta EG. Thapsigargin inhibits Ca2+ uptake, and Ca2+ depletes sarcoplasmic reticulum in intact cardiac myocytes. Am J Physiol 1993;265:H517-22. (Pubitemid 23273586)
32. Secondo A, Staiano RI, Scorziello A, Sirabella R, Boscia F, Adornetto A, et al. BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potential. Cell Calcium 2007;42:521-35. (Pubitemid 47471355)
33. Cala SE, Ulbright C, Kelley JS, Jones LR. Purification of a 90-kDa protein (Band VII) from cardiac sarcoplasmic reticulum. Identification as calnexin and localization of casein kinase II phosphorylation sites. J Biol Chem 1993;268:2969-75. (Pubitemid 23057936)
34. Wang G, Yang ZQ, Zhang K. Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res 2010;2:65-74.
35. Martinez JA, Zhang Z, Svetlov SI, Hayes RL, Wang KK, Larner SF. Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis 2010;15:1480-93.
36. Ni M, Lee AS. ER chaperones in mammalian development and human diseases. FEBS Lett 2007;581:3641-51. (Pubitemid 47082516)
37. Rasola A, Sciacovelli M, Pantic B, Bernardi P. Signal transduction to the permeability transition pore. FEBS Lett 2010;584:1989-96.
38. Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R. Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 2010;105:771-85.
39. Ong DS, Mu TW, Palmer AE, Kelly JW. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nat Chem Biol 2010;6:424-32.
40. Mattson MP. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxid Redox Signal 2006;8:1997-2006. (Pubitemid 46489627)
41. Sulova Z, Seres M, Barancik M, Gibalova L, Uhrik B, Polekova L, et al. Does any relationship exist between P-glycoprotein-mediated multidrug resistance and intracellular calcium homeostasis. Gen Physiol Biophys 2009;28:F89-95.
42. Sirabella R, Secondo A, Pannaccione A, Scorziello A, Valsecchi V, Adornetto A, et al. Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons. Stroke 2009;40:922-9.
43. Padar S, van Breemen C, Thomas DW, Uchizono JA, Livesey JC, Rahimian R. Differential regulation of calcium homeostasis in adenocarcinoma cell line A549 and its Taxol-resistant subclone. Br J Pharmacol 2004;142:305-16. (Pubitemid 38746166)
44. Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest 2011;121:1349-60.
45. Takemoto K, Miyata S, Takamura H, Katayama T, Tohyama M. Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum. Neurochem Int 2011;58:880-7.
46. Amoroso MR, Matassa DS, Laudiero G, Egorova AV, Polishchuk RS, Maddalena F, et al. TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins. Cell Death Differ. Epub 2011 Oct 7.
47. O'Neil BH, Goldberg RM. Chemotherapy for advanced colorectal cancer: let's not forget how we got here (until we really can). Semin Oncol 2005;32:35-42. (Pubitemid 40250124)