Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

EMBO Molecular Medicine

Volumn 8, Issue 7, 2016, Pages 729-744

  Heindryckx, Femke ^a   Binet, François ^a   Ponticos, Markella ^b   Rombouts, Krista ^b   Lau, Joey ^a   Kreuger, Johan ^a   Gerwins, Pär ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

endoplasmic reticulum stress; fibrosis; liver cirrhosis; myofibroblast; scleroderma

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MICRORNA; MICRORNA 150; PROTEIN C MYB; PROTEIN IRE1; PROTEIN IRE1ALPHA; RIBONUCLEASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MOUSE; MUTANT; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; UNFOLDED PROTEIN RESPONSE;

EID: 84977640740     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505925     Document Type: Article

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