Activation of hepatic stellate cells is suppressed by microRNA-150

International Journal of Molecular Medicine

Volumn 32, Issue 1, 2013, Pages 17-24

  Zheng, Jianjian ^a   Lin, Zhuo ^a   Dong, Peihong ^a   Lu, Zhongqiu ^a   Gao, Shenmeng ^a   Chen, Xiaoqian ^a   Wu, Cunzao ^a   Yu, Fujun ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Hepatic stellate cells; Liver fibrosis; microRNA 150

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; MICRORNA; MICRORNA 150; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING KINETICS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; STELLATE CELL;

CELL LINE; CLUSTER ANALYSIS; COLLAGEN TYPE IV; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; MICRORNAS; RNA INTERFERENCE; SP1 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84878243687     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1356     Document Type: Article

References (33)

1. Schuppan D, Krebs A, Bauer M and Hahn EG: Hepatitis C and liver fibrosis. Cell Death Differ 10 (Suppl 1): S59-S67, 2003. (Pubitemid 36511853)
2. Gressner OA, Rizk MS, Kovalenko E, Weiskirchen R and Gressner AM: Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go? J Gastroenterol Hepatol 23: 1024-1035, 2008. (Pubitemid 352019381)
3. Kong X, Horiguchi N, Mori M and Gao B: Cytokines and STATs in liver fibrosis. Front Physiol 3: 69, 2012.
4. Friedman SL: Mechanisms of hepatic fibrogenesis. Gastroenterology 134: 1655-1669, 2008.
5. Vettori S, Gay S and Distler O: Role of microRNAs in fibrosis. Open Rheumatol J 6: 130-139, 2012.
6. Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH and Cuppen E: Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120: 21-24, 2005. (Pubitemid 40094599)
7. Kozomara A and Griffiths-Jones S: miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39: D152-D157, 2011.
8. Brennecke J, Hipfner DR, Stark A, Russell RB and Cohen SM: bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113: 25-36, 2003. (Pubitemid 36411957)
9. Schratt GM, Tuebing F, Nigh EA, et al: A brain-specific microRNA regulates dendritic spine development. Nature 439: 283-289, 2006. (Pubitemid 43128846)
10. Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86, 2004. (Pubitemid 38055775)
11. Mott JL, Kobayashi S, Bronk SF and Gores GJ: mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26: 6133-6140, 2007. (Pubitemid 47414372)
12. Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 11: 441-450, 2006. (Pubitemid 44430905)
13. Chen L, Jiang M, Yuan W and Tang H: miR-17-5p as a novel prognostic marker for hepatocellular carcinoma. J Invest Surg 25: 156-161, 2012.
14. Yang F, Yin Y, Wang F, et al: miR-17-5p promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology 51: 1614-1623, 2010.
15. Venugopal SK, Jiang J, Kim TH, et al: Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol 298: G101-G106, 2010.
16. Ji J, Zhang J, Huang G, Qian J, Wang X and Mei S: Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583: 759-766, 2009.
17. Iizuka M, Ogawa T, Enomoto M, et al: Induction of microRNA-214-5p in human and rodent liver fibrosis. Fibrogenesis Tissue Repair 5: 12, 2012.
18. Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108, 2008. (Pubitemid 351818697)
19. Thompson WJ, Piazza GA, Li H, et al: Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res 60: 3338-3342, 2000. (Pubitemid 30482142)
20. Gressner AM, Weiskirchen R, Breitkopf K and Dooley S: Roles of TGF-beta in hepatic fibrosis. Front Biosci 7: d793-d807, 2002.
21. Sysa P, Potter JJ, Liu X and Mezey E: Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol 28: 425-434, 2009.
22. Bataller R and Brenner DA: Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 21: 437-451, 2001. (Pubitemid 32923771)
23. Friedman SL: Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250, 2000.
24. Wu J and Zern MA: Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 35: 665-672, 2000.
25. Kwiecinski M, Noetel A, Elfimova N, et al: Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS One 6: e24568, 2011.
26. Gressner AM and Weiskirchen R: Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 10: 76-99, 2006. (Pubitemid 44874293)
27. Geerts A, Schuppan D, Lazeroms S, De Zanger R and Wisse E: Collagen type I and III occur together in hybrid fibrils in the space of Disse of normal rat liver. Hepatology 12: 233-241, 1990. (Pubitemid 20285785)
28. Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO and Stein H: Cellular localization of type I III and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol 137: 59-70, 1990. (Pubitemid 20229589)
29. Sekiya Y, Ogawa T, Yoshizato K, Ikeda K and Kawada N: Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun 412: 74-79, 2011.
30. Ogawa T, Iizuka M, Sekiya Y, Yoshizato K, Ikeda K and Kawada N: Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun 391: 316-321, 2010.
31. Xu L, Hui AY, Albanis E, et al: Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 54: 142-151, 2005. (Pubitemid 40007234)
32. Kitada T, Seki S, Nakatani K, Kawada N, Kuroki T and Monna T: Hepatic expression of c-Myb in chronic human liver disease. Hepatology 26: 1506-1512, 1997. (Pubitemid 27520016)
33. Lee KS, Buck M, Houglum K and Chojkier M: Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96: 2461-2468, 1995.