MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells

American Journal of Physiology - Cell Physiology

Volumn 303, Issue 4, 2012, Pages

  Rombouts, Krista ^a   Mello, Tommaso ^a   Liotta, Francesco ^a   Galli, Andrea ^a   Caligiuri, Alessandra ^a   Annunziato, Francesco ^a   Pinzani, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cell cycle mitosis; Confocal analysis; MARCKS Aurora B kinase; Quantitative live cell imaging; RNA interference

Indexed keywords

ACTIN BINDING PROTEIN; ALPHA TUBULIN; AURORA B KINASE; BETA ACTIN; F ACTIN; GAMMA TUBULIN; MARCKS PROTEIN;

ACTIN FILAMENT; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CELL STRUCTURE; CHROMOSOME; CONTROLLED STUDY; CYTOKINESIS; CYTOSKELETON; CYTOSOL; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR INTERACTION; POLYMERIZATION; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; STELLATE CELL; TELOPHASE; UPREGULATION;

ACTINS; ANTIBODIES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CENTROSOME; CYTOSKELETON; HEPATIC STELLATE CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MITOSIS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; STAINING AND LABELING;

EID: 84865151677     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00093.2012     Document Type: Article

References (46)

1. Arbuzova A, Schmitz AA, Vergeres G. Cross-talk unfolded: MARCKS proteins. Biochem J 362: 1-12, 2002.
2. Arbuzova A, Wang L, Wang J, Hangyas-Mihalyne G, Murray D, Honig B, McLaughlin S. Membrane binding of peptides containing both basic and aromatic residues. Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS. Biochemistry 39: 10330-10339, 2000.
3. Barr FA, Gruneberg U. Cytokinesis: placing and making the final cut. Cell 131: 847-860, 2007.
4. Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chan CS, Novotny M, Slamon DJ, Plowman GD. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17: 3052-3065, 1998.
5. Boers W, Aarrass S, Linthorst C, Pinzani M, Elferink RO, Bosma P. Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins. J Biol Chem 281: 16289-16295, 2006.
6. Brawley SH, Robinson KR. Cytochalasin treatment disrupts the endogenous currents associated with cell polarization in fucoid zygotes: studies of the role of F-actin in embryogenesis. J Cell Biol 100: 1173-1184, 1985.
7. Carmena M, Ruchaud S, Earnshaw WC. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins. Curr Opin Cell Biol 21: 796-805, 2009.
8. Carney BK, Caruso Silva V, Cassimeris L. The microtubule cytoskeleton is required for a G2 cell cycle delay in cancer cells lacking stathmin and p53. Cytoskeleton (Hoboken) 69: 278-289, 2012.
9. Cassiman D, Roskams T. Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research. J Hepatol 37: 527-535, 2002.
10. Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis. Nature 464: 1062-1066, 2010.
11. Dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA, Nosworthy NJ. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev 83: 433-473, 2003.
12. Effler JC, Kee YS, Berk JM, Tran MN, Iglesias PA, Robinson DN. Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Curr Biol 16: 1962-1967, 2006.
13. Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88: 125-172, 2008.
14. Gassmann R, Henzing AJ, Earnshaw WC. Novel components of human mitotic chromosomes identified by proteomic analysis of the chromosome scaffold fraction. Chromosoma 113: 385-397, 2005.
15. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356: 618-622, 1992.
16. Herget T, Brooks SF, Broad S, Rozengurt E. Expression of the major protein kinase C substrate, the acidic 80-kilodalton myristoylated alaninerich C kinase substrate, increases sharply when Swiss 3T3 cells move out of cycle and enter G0. Proc Natl Acad Sci USA 90: 2945-2949, 1993.
17. Hinz B, Phan SH, Thannickal VJ, Prunotto M, Desmouliere A, Varga J, De Wever O, Mareel M, Gabbiani G. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 180: 1340-1355, 2012.
18. Hirota T, Lipp JJ, Toh BH, Peters JM. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438: 1176-1180, 2005.
19. Johnstone SR, Best AK, Wright CS, Isakson BE, Errington RJ, Martin PE. Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function. J Cell Biochem 110: 772-782, 2010.
20. Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta 1799: 829-839, 2010.
21. Laux T, Fukami K, Thelen M, Golub T, Frey D, Caroni P. GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol 149: 1455-1472, 2000.
22. Lenart P, Bacher CP, Daigle N, Hand AR, Eils R, Terasaki M, Ellenberg J. A contractile nuclear actin network drives chromosome congression in oocytes. Nature 436: 812-818, 2005.
23. Marra F, DeFranco R, Grappone C, Milani S, Pastacaldi S, Pinzani M, Romanelli RG, Laffi G, Gentilini P. Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration. Am J Pathol 152: 423-430, 1998.
24. McLaughlin S, Aderem A. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem Sci 20: 272-276, 1995.
25. Michaut MA, Williams CJ, Schultz RM. Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs. Dev Biol 280: 26-37, 2005.
26. Milani S, Grappone C, Pellegrini G, Schuppan D, Herbst H, Calabro A, Casini A, Pinzani M, Surrenti C. Undulin RNA and protein expression in normal and fibrotic human liver. Hepatology 20: 908-916, 1994.
27. Murthy K, Wadsworth P. Dual role for microtubules in regulating cortical contractility during cytokinesis. J Cell Sci 121: 2350-2359, 2008.
28. Odena G, Bataller B. Actin-binding proteins as molecular targets to modulate hepatic stellate cell proliferation. Focus on "MARCKS actinbinding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells." Am J Physiol Cell Physiol (June 27, 2012). doi:10.1152/ajpcell.00192.2012.
29. Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM. The DNAdamage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis. Proc Natl Acad Sci USA 106: 5159-5164, 2009.
30. Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, Giotti A, Gentilini P. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest 90: 642-646, 1992.
31. Reed JC, Rapp U, Cuddy MP. Transformed 3T3 cells have reduced levels and altered subcellular distribution of the major PKC substrate protein MARCKS. Cell Signal 3: 569-576, 1991.
32. Rizvi SA, Liu S, Chen Z, Skau C, Pytynia M, Kovar DR, Chmura SJ, Kozmin SA. Rationally simplified bistramide analog reversibly targets actin polymerization and inhibits cancer progression in vitro and in vivo. J Am Chem Soc 132: 7288-7290, 2010.
33. Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, Waterman-Storer CM. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol 5: 599-609, 2003.
34. Rombouts K, Lottini B, Caligiuri A, Liotta F, Mello T, Carloni V, Marra F, Pinzani M. MARCKS is a downstream effector in plateletderived growth factor-induced cell motility in activated human hepatic stellate cells. Exp Cell Res 314: 1444-1454, 2008.
35. Rottner K, Stradal TE. Actin dynamics and turnover in cell motility. Curr Opin Cell Biol 23: 569-578, 2011.
36. Ruchaud S, Carmena M, Earnshaw WC. The chromosomal passenger complex: one for all and all for one. Cell 131: 230-231, 2007.
37. Seykora JT, Myat MM, Allen LA, Ravetch JV, Aderem A. Molecular determinants of the myristoyl-electrostatic switch of MARCKS. J Biol Chem 271: 18797-18802, 1996.
38. Shan D, Chen L, Njardarson JT, Gaul C, Ma X, Danishefsky SJ, Huang XY. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc Natl Acad Sci USA 102: 3772-3776, 2005.
39. Steigemann P, Wurzenberger C, Schmitz MH, Held M, Guizetti J, Maar S, Gerlich DW. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell 136: 473-484, 2009.
40. Sundaram M, Cook HW, Byers DM. The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular components. Biochem Cell Biol 82: 191-200, 2004.
41. Thery M, Bornens M. Cell shape and cell division. Curr Opin Cell Biol 18: 648-657, 2006.
42. Thery M, Racine V, Pepin A, Piel M, Chen Y, Sibarita JB, Bornens M. The extracellular matrix guides the orientation of the cell division axis. Nat Cell Biol 7: 947-953, 2005.
43. Van Hooser AA, Yuh P, Heald R. The perichromosomal layer. Chromosoma 114: 377-388, 2005.
44. Wang J, Arbuzova A, Hangyas-Mihalyne G, McLaughlin S. The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J Biol Chem 276: 5012-5019, 2001.
45. Wohnsland F, Schmitz AA, Steinmetz MO, Aebi U, Vergeres G. Interaction between actin and the effector peptide of MARCKS-related protein. Identification of functional amino acid segments. J Biol Chem 275: 20873-20879, 2000.
46. Zhu X, Wang J, Moriguchi K, Liow LT, Ahmed S, Kaverina I, Murata-Hori M. Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Exp Cell Res 317: 2384-2389, 2011.