메뉴 건너뛰기




Volumn 19, Issue 2, 2016, Pages 99-111

Molecular portrait of the normal human breast tissue and its influence on breast carcinogenesis

Author keywords

Breast neoplasms; Carcinogenesis; Normal mammary gland; Transcriptome

Indexed keywords

ALPHA6 INTEGRIN; ANDROGEN RECEPTOR; BRCA1 PROTEIN; BRCA2 PROTEIN; CD24 ANTIGEN; CETUXIMAB; CYTOKERATIN 14; CYTOKERATIN 19; EDRECOLOMAB; ENZALUTAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPITHELIAL CELL ADHESION MOLECULE; ESTROGEN RECEPTOR; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; KI 67 ANTIGEN; MAMMAGLOBIN; MUCIN 1; MYC PROTEIN; PODOPLANIN; PROGESTERONE RECEPTOR; PROTEIN BCL 2; SALINOMYCIN; TRANSCRIPTOME; TRASTUZUMAB; UNINDEXED DRUG; UVOMORULIN;

EID: 84977473449     PISSN: 17386756     EISSN: 20929900     Source Type: Journal    
DOI: 10.4048/jbc.2016.19.2.99     Document Type: Review
Times cited : (9)

References (142)
  • 1
    • 77958066728 scopus 로고    scopus 로고
    • Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines
    • Keller PJ, Lin AF, Arendt LM, Klebba I, Jones AD, Rudnick JA, et al. Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res 2010; 12:R87.
    • (2010) Breast Cancer Res , vol.12
    • Keller, P.J.1    Lin, A.F.2    Arendt, L.M.3    Klebba, I.4    Jones, A.D.5    Rudnick, J.A.6
  • 2
    • 0036317839 scopus 로고    scopus 로고
    • Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas
    • Larson PS, de las Morenas A, Bennett SR, Cupples LA, Rosenberg CL. Loss of heterozygosity or allele imbalance in histologically normal breast epithelium is distinct from loss of heterozygosity or allele imbalance in co-existing carcinomas. Am J Pathol 2002; 161:283-90.
    • (2002) Am J Pathol , vol.161 , pp. 283-290
    • Larson, P.S.1    de las Morenas, A.2    Bennett, S.R.3    Cupples, L.A.4    Rosenberg, C.L.5
  • 4
    • 0030059759 scopus 로고    scopus 로고
    • Contiguous patches of normal human mammary epithelium derived from a single stem cell: Implications for breast carcinogenesis
    • Tsai YC, Lu Y, Nichols PW, Zlotnikov G, Jones PA, Smith HS. Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis. Cancer Res 1996; 56:402-4.
    • (1996) Cancer Res , vol.56 , pp. 402-404
    • Tsai, Y.C.1    Lu, Y.2    Nichols, P.W.3    Zlotnikov, G.4    Jones, P.A.5    Smith, H.S.6
  • 6
    • 0034880458 scopus 로고    scopus 로고
    • Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue
    • Stingl J, Eaves CJ, Zandieh I, Emerman JT. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat 2001; 67:93-109.
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 93-109
    • Stingl, J.1    Eaves, C.J.2    Zandieh, I.3    Emerman, J.T.4
  • 7
    • 48649096223 scopus 로고    scopus 로고
    • Transcriptome analysis of the normal human mammary cell commitment and differentiation process
    • Raouf A, Zhao Y, To K, Stingl J, Delaney A, Barbara M, et al. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell 2008; 3:109-18.
    • (2008) Cell Stem Cell , vol.3 , pp. 109-118
    • Raouf, A.1    Zhao, Y.2    To, K.3    Stingl, J.4    Delaney, A.5    Barbara, M.6
  • 8
    • 57349148680 scopus 로고    scopus 로고
    • A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
    • Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, et al. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 2008; 14:1384-9.
    • (2008) Nat Med , vol.14 , pp. 1384-1389
    • Eirew, P.1    Stingl, J.2    Raouf, A.3    Turashvili, G.4    Aparicio, S.5    Emerman, J.T.6
  • 9
    • 0023950817 scopus 로고
    • Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue
    • Dairkee SH, Puett L, Hackett AJ. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J Natl Cancer Inst 1988; 80:691-5.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 691-695
    • Dairkee, S.H.1    Puett, L.2    Hackett, A.J.3
  • 10
    • 0035863008 scopus 로고    scopus 로고
    • Mammary epithelial stem cells
    • Smith GH, Chepko G. Mammary epithelial stem cells. Microsc Res Tech 2001; 52:190-203.
    • (2001) Microsc Res Tech , vol.52 , pp. 190-203
    • Smith, G.H.1    Chepko, G.2
  • 11
    • 0025129726 scopus 로고
    • Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
    • Soule HD, Maloney TM, Wolman SR, Peterson WD Jr, Brenz R, McGrath CM, et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 1990; 50: 6075-86.
    • (1990) Cancer Res , vol.50 , pp. 6075-6086
    • Soule, H.D.1    Maloney, T.M.2    Wolman, S.R.3    Peterson, W.D.4    Brenz, R.5    McGrath, C.M.6
  • 12
    • 0037380886 scopus 로고    scopus 로고
    • Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia
    • Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, et al. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 2003; 63:1596-601.
    • (2003) Cancer Res , vol.63 , pp. 1596-1601
    • Holst, C.R.1    Nuovo, G.J.2    Esteller, M.3    Chew, K.4    Baylin, S.B.5    Herman, J.G.6
  • 13
    • 84893831447 scopus 로고    scopus 로고
    • Taxonomy of breast cancer based on normal cell phenotype predicts outcome
    • Santagata S, Thakkar A, Ergonul A, Wang B, Woo T, Hu R, et al. Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J Clin Invest 2014; 124:859-70.
    • (2014) J Clin Invest , vol.124 , pp. 859-870
    • Santagata, S.1    Thakkar, A.2    Ergonul, A.3    Wang, B.4    Woo, T.5    Hu, R.6
  • 14
    • 77950867131 scopus 로고    scopus 로고
    • Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile
    • Graham K, de las Morenas A, Tripathi A, King C, Kavanah M, Mendez J, et al. Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile. Br J Cancer 2010; 102:1284-93.
    • (2010) Br J Cancer , vol.102 , pp. 1284-1293
    • Graham, K.1    de las Morenas, A.2    Tripathi, A.3    King, C.4    Kavanah, M.5    Mendez, J.6
  • 15
    • 77949410426 scopus 로고    scopus 로고
    • Comparison of breast cancer to healthy control tissue discovers novel markers with potential for prognosis and early detection
    • Schummer M, Green A, Beatty JD, Karlan BY, Karlan S, Gross J, et al. Comparison of breast cancer to healthy control tissue discovers novel markers with potential for prognosis and early detection. PLoS One 2010; 5:e9122.
    • (2010) PLoS One , vol.5
    • Schummer, M.1    Green, A.2    Beatty, J.D.3    Karlan, B.Y.4    Karlan, S.5    Gross, J.6
  • 16
    • 39649114097 scopus 로고    scopus 로고
    • Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients
    • Tripathi A, King C, de la Morenas A, Perry VK, Burke B, Antoine GA, et al. Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients. Int J Cancer 2008; 122:1557-66.
    • (2008) Int J Cancer , vol.122 , pp. 1557-1566
    • Tripathi, A.1    King, C.2    de la Morenas, A.3    Perry, V.K.4    Burke, B.5    Antoine, G.A.6
  • 17
    • 84938420620 scopus 로고    scopus 로고
    • Gene expression abnormalities in histologically normal breast epithelium from patients with luminal type of breast cancer
    • Zubor P, Hatok J, Moricova P, Kajo K, Kapustova I, Mendelova A, et al. Gene expression abnormalities in histologically normal breast epithelium from patients with luminal type of breast cancer. Mol Biol Rep 2015; 42:977-88.
    • (2015) Mol Biol Rep , vol.42 , pp. 977-988
    • Zubor, P.1    Hatok, J.2    Moricova, P.3    Kajo, K.4    Kapustova, I.5    Mendelova, A.6
  • 18
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL, et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 2001; 15:50-65.
    • (2001) Genes Dev , vol.15 , pp. 50-65
    • Elenbaas, B.1    Spirio, L.2    Koerner, F.3    Fleming, M.D.4    Zimonjic, D.B.5    Donaher, J.L.6
  • 19
    • 0032694152 scopus 로고    scopus 로고
    • Genetic alterations in 'normal' luminal and myoepithelial cells of the breast
    • Lakhani SR, Chaggar R, Davies S, Jones C, Collins N, Odel C, et al. Genetic alterations in 'normal' luminal and myoepithelial cells of the breast. J Pathol 1999; 189:496-503.
    • (1999) J Pathol , vol.189 , pp. 496-503
    • Lakhani, S.R.1    Chaggar, R.2    Davies, S.3    Jones, C.4    Collins, N.5    Odel, C.6
  • 21
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396:643-9.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 22
    • 84860345328 scopus 로고    scopus 로고
    • Histologic findings in normal breast tissues: Comparison to reduction mammaplasty and benign breast disease tissues
    • Degnim AC, Visscher DW, Hoskin TL, Frost MH, Vierkant RA, Vachon CM, et al. Histologic findings in normal breast tissues: comparison to reduction mammaplasty and benign breast disease tissues. Breast Cancer Res Treat 2012; 133:169-77.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 169-177
    • Degnim, A.C.1    Visscher, D.W.2    Hoskin, T.L.3    Frost, M.H.4    Vierkant, R.A.5    Vachon, C.M.6
  • 23
    • 33750705865 scopus 로고    scopus 로고
    • Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data
    • Grigoriadis A, Mackay A, Reis-Filho JS, Steele D, Iseli C, Stevenson BJ, et al. Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data. Breast Cancer Res 2006; 8:R56.
    • (2006) Breast Cancer Res , vol.8
    • Grigoriadis, A.1    Mackay, A.2    Reis-Filho, J.S.3    Steele, D.4    Iseli, C.5    Stevenson, B.J.6
  • 24
    • 84892619683 scopus 로고    scopus 로고
    • Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
    • Liu S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Reports 2013; 2:78-91.
    • (2013) Stem Cell Reports , vol.2 , pp. 78-91
    • Liu, S.1    Cong, Y.2    Wang, D.3    Sun, Y.4    Deng, L.5    Liu, Y.6
  • 25
    • 84872372346 scopus 로고    scopus 로고
    • An RNA-seq-based gene expression profiling of radiation-induced tumorigenic mammary epithelial cells
    • Ma L, Nie L, Liu J, Zhang B, Song S, Sun M, et al. An RNA-seq-based gene expression profiling of radiation-induced tumorigenic mammary epithelial cells. Genomics Proteomics Bioinformatics 2012; 10:326-35.
    • (2012) Genomics Proteomics Bioinformatics , vol.10 , pp. 326-335
    • Ma, L.1    Nie, L.2    Liu, J.3    Zhang, B.4    Song, S.5    Sun, M.6
  • 26
    • 79953176619 scopus 로고    scopus 로고
    • Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit
    • Smart CE, Wronski A, French JD, Edwards SL, Asselin-Labat ML, Waddell N, et al. Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit. Oncogene 2011; 30: 1597-607.
    • (2011) Oncogene , vol.30 , pp. 1597-1607
    • Smart, C.E.1    Wronski, A.2    French, J.D.3    Edwards, S.L.4    Asselin-Labat, M.L.5    Waddell, N.6
  • 27
    • 84887557103 scopus 로고    scopus 로고
    • Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic
    • Al-Rakan MA, Colak D, Hendrayani SF, Al-Bakheet A, Al-Mohanna FH, Kaya N, et al. Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic. J Pathol 2013; 231:457-65.
    • (2013) J Pathol , vol.231 , pp. 457-465
    • Al-Rakan, M.A.1    Colak, D.2    Hendrayani, S.F.3    Al-Bakheet, A.4    Al-Mohanna, F.H.5    Kaya, N.6
  • 29
    • 84957831564 scopus 로고    scopus 로고
    • Differential HIF-1alpha and HIF-2alpha expression in mammary epithelial cells during fat pad invasion, lactation, and involution
    • Påhlman S, Lund LR, Jögi A. Differential HIF-1alpha and HIF-2alpha expression in mammary epithelial cells during fat pad invasion, lactation, and involution. PLoS One 2015; 10:e0125771.
    • (2015) PLoS One , vol.10
    • Påhlman, S.1    Lund, L.R.2    Jögi, A.3
  • 32
    • 0032491686 scopus 로고    scopus 로고
    • Does estrogen receptor expression in normal breast tissue predict breast cancer risk?
    • Bernstein L, Press MF. Does estrogen receptor expression in normal breast tissue predict breast cancer risk? J Natl Cancer Inst 1998; 90:5-7.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 5-7
    • Bernstein, L.1    Press, M.F.2
  • 33
    • 77951745890 scopus 로고    scopus 로고
    • Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer
    • Buxant F, Engohan-Aloghe C, Noël JC. Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer. Appl Immunohistochem Mol Morphol 2010; 18:254-7.
    • (2010) Appl Immunohistochem Mol Morphol , vol.18 , pp. 254-257
    • Buxant, F.1    Engohan-Aloghe, C.2    Noël, J.C.3
  • 35
    • 0036888655 scopus 로고    scopus 로고
    • Estrogen receptor alpha expression in normal human breast epithelium is consistent over time
    • Khan SA, Yee KA, Kaplan C, Siddiqui JF. Estrogen receptor alpha expression in normal human breast epithelium is consistent over time. Int J Cancer 2002; 102:334-7.
    • (2002) Int J Cancer , vol.102 , pp. 334-337
    • Khan, S.A.1    Yee, K.A.2    Kaplan, C.3    Siddiqui, J.F.4
  • 36
    • 0032795728 scopus 로고    scopus 로고
    • Estrogen receptor-positive proliferating cells in the normal and precancerous breast
    • Shoker BS, Jarvis C, Clarke RB, Anderson E, Hewlett J, Davies MP, et al. Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am J Pathol 1999; 155:1811-5.
    • (1999) Am J Pathol , vol.155 , pp. 1811-1815
    • Shoker, B.S.1    Jarvis, C.2    Clarke, R.B.3    Anderson, E.4    Hewlett, J.5    Davies, M.P.6
  • 38
    • 0037050742 scopus 로고    scopus 로고
    • Breast cancer incidence and estrogen receptor alpha in normal mammary tissue: An epidemiologic study among Japanese women in Japan and Hawaii
    • Lawson JS, Field AS, Tran DD, Killeen J, Maskarenic G, Ishikura H, et al. Breast cancer incidence and estrogen receptor alpha in normal mammary tissue: an epidemiologic study among Japanese women in Japan and Hawaii. Int J Cancer 2002; 97:685-7.
    • (2002) Int J Cancer , vol.97 , pp. 685-687
    • Lawson, J.S.1    Field, A.S.2    Tran, D.D.3    Killeen, J.4    Maskarenic, G.5    Ishikura, H.6
  • 39
    • 84893513998 scopus 로고    scopus 로고
    • Differential expression of estrogen receptor alpha, beta1, and beta2 in lobular and ductal breast cancer
    • Huang B, Omoto Y, Iwase H, Yamashita H, Toyama T, Coombes RC, et al. Differential expression of estrogen receptor alpha, beta1, and beta2 in lobular and ductal breast cancer. Proc Natl Acad Sci U S A 2014; 111:1933-8.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 1933-1938
    • Huang, B.1    Omoto, Y.2    Iwase, H.3    Yamashita, H.4    Toyama, T.5    Coombes, R.C.6
  • 40
    • 84901338598 scopus 로고    scopus 로고
    • Estrogen receptor beta2 is inversely correlated with Ki-67 in hyperplastic and noninvasive neoplastic breast lesions
    • Chantzi NI, Palaiologou M, Stylianidou A, Goutas N, Vassilaros S, Kourea HP, et al. Estrogen receptor beta2 is inversely correlated with Ki-67 in hyperplastic and noninvasive neoplastic breast lesions. J Cancer Res Clin Oncol 2014; 140:1057-66.
    • (2014) J Cancer Res Clin Oncol , vol.140 , pp. 1057-1066
    • Chantzi, N.I.1    Palaiologou, M.2    Stylianidou, A.3    Goutas, N.4    Vassilaros, S.5    Kourea, H.P.6
  • 42
    • 81055148214 scopus 로고    scopus 로고
    • Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment
    • Fasching PA, Heusinger K, Haeberle L, Niklos M, Hein A, Bayer CM. et al. Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment. BMC Cancer 2011; 11:486.
    • (2011) BMC Cancer , vol.11 , pp. 486
    • Fasching, P.A.1    Heusinger, K.2    Haeberle, L.3    Niklos, M.4    Hein, A.5    Bayer, C.M.6
  • 44
    • 0033876197 scopus 로고    scopus 로고
    • Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer
    • Järvinen TA, Pelto-Huikko M, Holli K, Isola J. Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol 2000; 156:29-35.
    • (2000) Am J Pathol , vol.156 , pp. 29-35
    • Järvinen, T.A.1    Pelto-Huikko, M.2    Holli, K.3    Isola, J.4
  • 45
    • 62149119528 scopus 로고    scopus 로고
    • The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR
    • Green AR, Young P, Krivinskas S, Rakha EA, Claire Paish E, Powe DG, et al. The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR. Histopathology 2009; 54:419-27.
    • (2009) Histopathology , vol.54 , pp. 419-427
    • Green, A.R.1    Young, P.2    Krivinskas, S.3    Rakha, E.A.4    Claire Paish, E.5    Powe, D.G.6
  • 47
    • 0019137981 scopus 로고
    • Progesterone receptors in normal mammary gland: Receptor modulations in relation to differentiation
    • Haslam SZ, Shyamala G. Progesterone receptors in normal mammary gland: receptor modulations in relation to differentiation. J Cell Biol 1980; 86:730-7.
    • (1980) J Cell Biol , vol.86 , pp. 730-737
    • Haslam, S.Z.1    Shyamala, G.2
  • 48
    • 0035995602 scopus 로고    scopus 로고
    • The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
    • Anderson E. The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res 2002; 4:197-201.
    • (2002) Breast Cancer Res , vol.4 , pp. 197-201
    • Anderson, E.1
  • 49
    • 0023751211 scopus 로고
    • Acquisition of estrogen-dependent progesterone receptors by normal mouse mammary gland: Ontogeny of mammary progesterone receptors
    • Haslam SZ. Acquisition of estrogen-dependent progesterone receptors by normal mouse mammary gland: ontogeny of mammary progesterone receptors. J Steroid Biochem 1988; 31:9-13.
    • (1988) J Steroid Biochem , vol.31 , pp. 9-13
    • Haslam, S.Z.1
  • 50
    • 0025066468 scopus 로고
    • Progesterone action in normal mouse mammary gland
    • Wang S, Counterman LJ, Haslam SZ. Progesterone action in normal mouse mammary gland. Endocrinology 1990; 127:2183-9.
    • (1990) Endocrinology , vol.127 , pp. 2183-2189
    • Wang, S.1    Counterman, L.J.2    Haslam, S.Z.3
  • 52
    • 0025359146 scopus 로고
    • Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues
    • Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990; 5:953-62.
    • (1990) Oncogene , vol.5 , pp. 953-962
    • Press, M.F.1    Cordon-Cardo, C.2    Slamon, D.J.3
  • 53
    • 84882779627 scopus 로고    scopus 로고
    • Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue
    • Flågeng MH, Knappskog S, Haynes BP, Lønning PE, Mellgren G. Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. PLoS One 2013; 8:e74618.
    • (2013) PLoS One , vol.8
    • Flågeng, M.H.1    Knappskog, S.2    Haynes, B.P.3    Lønning, P.E.4    Mellgren, G.5
  • 54
    • 0037382283 scopus 로고    scopus 로고
    • Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome
    • Camp RL, Dolled-Filhart M, King BL, Rimm DL. Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome. Cancer Res 2003; 63:1445-8.
    • (2003) Cancer Res , vol.63 , pp. 1445-1448
    • Camp, R.L.1    Dolled-Filhart, M.2    King, B.L.3    Rimm, D.L.4
  • 55
    • 79961145364 scopus 로고    scopus 로고
    • Standardized assessment of the HER2 status in breast cancer by immunohistochemistry
    • Hicks DG, Schiffhauer L. Standardized assessment of the HER2 status in breast cancer by immunohistochemistry. Lab Med 2011; 42:459-67.
    • (2011) Lab Med , vol.42 , pp. 459-467
    • Hicks, D.G.1    Schiffhauer, L.2
  • 56
    • 84878925004 scopus 로고    scopus 로고
    • Change in HER2 status during breast tumor progression
    • Niikura N, Ueno NT. Change in HER2 status during breast tumor progression. Cancer Biomark 2012-2013; 12:251-5.
    • (2012) Cancer Biomark , vol.12 , pp. 251-255
    • Niikura, N.1    Ueno, N.T.2
  • 57
    • 1842611495 scopus 로고    scopus 로고
    • Bcl-2 protein in normal, hyperplastic and neoplastic breast tissues: A metabolite of the putative stem-cell subpopulation of the mammary gland
    • Luna-Moré S, Weil B, Bautista D, Garrido E, Florez P, Martínez C. Bcl-2 protein in normal, hyperplastic and neoplastic breast tissues: a metabolite of the putative stem-cell subpopulation of the mammary gland. Histol Histopathol 2004; 19:457-63.
    • (2004) Histol Histopathol , vol.19 , pp. 457-463
    • Luna-Moré, S.1    Weil, B.2    Bautista, D.3    Garrido, E.4    Florez, P.5    Martínez, C.6
  • 58
    • 77955177382 scopus 로고    scopus 로고
    • Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity
    • Yu B, Sun X, Shen HY, Gao F, Fan YM, Sun ZJ. Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity. J Exp Clin Cancer Res 2010; 29:107.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 107
    • Yu, B.1    Sun, X.2    Shen, H.Y.3    Gao, F.4    Fan, Y.M.5    Sun, Z.J.6
  • 59
    • 0028944271 scopus 로고
    • Expression of the bcl-2 gene family in normal and malignant breast tissue: Low bax-alpha expression in tumor cells correlates with resistance towards apoptosis
    • Bargou RC, Daniel PT, Mapara MY, Bommert K, Wagener C, Kallinich B, et al. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer 1995; 60:854-9.
    • (1995) Int J Cancer , vol.60 , pp. 854-859
    • Bargou, R.C.1    Daniel, P.T.2    Mapara, M.Y.3    Bommert, K.4    Wagener, C.5    Kallinich, B.6
  • 60
    • 14844334976 scopus 로고    scopus 로고
    • Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: Association with nodule size, hormonal and reproductive features
    • Cericatto R, Pozzobon A, Morsch DM, Menke CH, Brum IS, Spritzer PM. Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. Steroids 2005; 70:153-60.
    • (2005) Steroids , vol.70 , pp. 153-160
    • Cericatto, R.1    Pozzobon, A.2    Morsch, D.M.3    Menke, C.H.4    Brum, I.S.5    Spritzer, P.M.6
  • 61
    • 84860827625 scopus 로고    scopus 로고
    • Expression of Ki-67 and Bcl-2 biomarkers in normal breast tissue from women of reproductive age treated with raloxifene
    • Lima MA, da Silva BB. Expression of Ki-67 and Bcl-2 biomarkers in normal breast tissue from women of reproductive age treated with raloxifene. Arch Gynecol Obstet 2012; 285:223-7.
    • (2012) Arch Gynecol Obstet , vol.285 , pp. 223-227
    • Lima, M.A.1    da Silva, B.B.2
  • 62
    • 0033973291 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland epithelium
    • Feuerhake F, Sigg W, Höfter EA, Dimpfl T, Welsch U. Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland epithelium. Cell Tissue Res 2000; 299:47-58.
    • (2000) Cell Tissue Res , vol.299 , pp. 47-58
    • Feuerhake, F.1    Sigg, W.2    Höfter, E.A.3    Dimpfl, T.4    Welsch, U.5
  • 64
    • 84905976059 scopus 로고    scopus 로고
    • Influence of stromal-epithelial interactions on androgen action
    • Nieto CM, Rider LC, Cramer SD. Influence of stromal-epithelial interactions on androgen action. Endocr Relat Cancer 2014; 21:T147-60.
    • (2014) Endocr Relat Cancer , vol.21 , pp. T147-T160
    • Nieto, C.M.1    Rider, L.C.2    Cramer, S.D.3
  • 65
    • 84946493131 scopus 로고    scopus 로고
    • Androgen receptor biology in triple negative breast cancer: A case for classification as AR+ or quadruple negative disease
    • Barton VN, D'Amato NC, Gordon MA, Christenson JL, Elias A, Richer JK. Androgen receptor biology in triple negative breast cancer: a case for classification as AR+ or quadruple negative disease. Horm Cancer 2015; 6:206-13.
    • (2015) Horm Cancer , vol.6 , pp. 206-213
    • Barton, V.N.1    D'Amato, N.C.2    Gordon, M.A.3    Christenson, J.L.4    Elias, A.5    Richer, J.K.6
  • 66
    • 84903776169 scopus 로고    scopus 로고
    • Human mammaglobin in breast cancer: A brief review of its clinical utility
    • Al Joudi FS. Human mammaglobin in breast cancer: a brief review of its clinical utility. Indian J Med Res 2014; 139:675-85.
    • (2014) Indian J Med Res , vol.139 , pp. 675-685
    • Al Joudi, F.S.1
  • 67
    • 84891553282 scopus 로고    scopus 로고
    • Upregulation of human mammaglobin reduces migration and invasion of breast cancer cells
    • Koh EH, Cho YW, Mun YJ, Ryu JH, Kim EJ, Choi DS, et al. Upregulation of human mammaglobin reduces migration and invasion of breast cancer cells. Cancer Invest 2014; 32:22-9.
    • (2014) Cancer Invest , vol.32 , pp. 22-29
    • Koh, E.H.1    Cho, Y.W.2    Mun, Y.J.3    Ryu, J.H.4    Kim, E.J.5    Choi, D.S.6
  • 68
    • 80052901704 scopus 로고    scopus 로고
    • Cloning expression, monoclonal antibody preparation and serologic study of mammaglobin in breast cancer
    • Huang Y, Zhang HQ, Wang J, Song XG, Wang GH, Guan Q, et al. Cloning expression, monoclonal antibody preparation and serologic study of mammaglobin in breast cancer. Neoplasma 2011; 58:436-40.
    • (2011) Neoplasma , vol.58 , pp. 436-440
    • Huang, Y.1    Zhang, H.Q.2    Wang, J.3    Song, X.G.4    Wang, G.H.5    Guan, Q.6
  • 69
    • 79551549744 scopus 로고    scopus 로고
    • A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes
    • Tafreshi NK, Enkemann SA, Bui MM, Lloyd MC, Abrahams D, Huynh AS, et al. A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes. Cancer Res 2011; 71:1050-9.
    • (2011) Cancer Res , vol.71 , pp. 1050-1059
    • Tafreshi, N.K.1    Enkemann, S.A.2    Bui, M.M.3    Lloyd, M.C.4    Abrahams, D.5    Huynh, A.S.6
  • 70
    • 78149392118 scopus 로고    scopus 로고
    • Immunohistochemical expression and correlation of mammaglobin with the grading system of breast carcinoma
    • Rehman F, Nagi AH, Hussain M. Immunohistochemical expression and correlation of mammaglobin with the grading system of breast carcinoma. Indian J Pathol Microbiol 2010; 53:619-23.
    • (2010) Indian J Pathol Microbiol , vol.53 , pp. 619-623
    • Rehman, F.1    Nagi, A.H.2    Hussain, M.3
  • 71
    • 57349114162 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule E-cadherin
    • van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 2008; 65:3756-88.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3756-3788
    • van Roy, F.1    Berx, G.2
  • 72
    • 0025325167 scopus 로고
    • Cadherins: A molecular family important in selective cell-cell adhesion
    • Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem 1990; 59:237-52.
    • (1990) Annu Rev Biochem , vol.59 , pp. 237-252
    • Takeichi, M.1
  • 73
    • 0034852853 scopus 로고    scopus 로고
    • The E-cadherin/catenin complex: An important gatekeeper in breast cancer tumorigenesis and malignant progression
    • Berx G, Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 2001; 3:289-93.
    • (2001) Breast Cancer Res , vol.3 , pp. 289-293
    • Berx, G.1    Van Roy, F.2
  • 75
    • 84923673777 scopus 로고    scopus 로고
    • Differential expression of E-cadherin in primary breast cancer and corresponding lymph node metastases
    • Fulga V, Rudico L, Balica AR, Cimpean AM, Saptefrati L, Margan MM, et al. Differential expression of E-cadherin in primary breast cancer and corresponding lymph node metastases. Anticancer Res 2015; 35:759-65.
    • (2015) Anticancer Res , vol.35 , pp. 759-765
    • Fulga, V.1    Rudico, L.2    Balica, A.R.3    Cimpean, A.M.4    Saptefrati, L.5    Margan, M.M.6
  • 76
    • 79958698938 scopus 로고    scopus 로고
    • D2-40: An additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion
    • Ren S, Abuel-Haija M, Khurana JS, Zhang X. D2-40: an additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion. Int J Clin Exp Pathol 2011; 4: 175-82.
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 175-182
    • Ren, S.1    Abuel-Haija, M.2    Khurana, J.S.3    Zhang, X.4
  • 77
    • 77951712970 scopus 로고    scopus 로고
    • Podoplanin expression in basal and myoepithelial cells: Utility and potential pitfalls
    • Kanner WA, Galgano MT, Atkins KA. Podoplanin expression in basal and myoepithelial cells: utility and potential pitfalls. Appl Immunohistochem Mol Morphol 2010; 18:226-30.
    • (2010) Appl Immunohistochem Mol Morphol , vol.18 , pp. 226-230
    • Kanner, W.A.1    Galgano, M.T.2    Atkins, K.A.3
  • 78
    • 38149021303 scopus 로고    scopus 로고
    • D2-40 expression by breast myoepithelium: Potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma
    • Rabban JT, Chen YY. D2-40 expression by breast myoepithelium: potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma. Hum Pathol 2008; 39:175-83.
    • (2008) Hum Pathol , vol.39 , pp. 175-183
    • Rabban, J.T.1    Chen, Y.Y.2
  • 80
    • 4644237511 scopus 로고    scopus 로고
    • Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology
    • Kaiserling E. Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology. Pathologe 2004; 25:362-74.
    • (2004) Pathologe , vol.25 , pp. 362-374
    • Kaiserling, E.1
  • 81
    • 0031940671 scopus 로고    scopus 로고
    • Spectrum of GCDFP-15 expression in human fetal and adult normal tissues
    • Viacava P, Naccarato AG, Bevilacqua G. Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. Virchows Arch 1998; 432:255-60.
    • (1998) Virchows Arch , vol.432 , pp. 255-260
    • Viacava, P.1    Naccarato, A.G.2    Bevilacqua, G.3
  • 82
    • 0028918218 scopus 로고
    • Mitogenic effect of the 15-kDa gross cystic disease fluid protein (GCDFP-15) on breast-cancer cell lines and on immortal mammary cells
    • Cassoni P, Sapino A, Haagensen DE, Naldoni C, Bussolati G. Mitogenic effect of the 15-kDa gross cystic disease fluid protein (GCDFP-15) on breast-cancer cell lines and on immortal mammary cells. Int J Cancer 1995; 60:216-20.
    • (1995) Int J Cancer , vol.60 , pp. 216-220
    • Cassoni, P.1    Sapino, A.2    Haagensen, D.E.3    Naldoni, C.4    Bussolati, G.5
  • 84
    • 84942235165 scopus 로고    scopus 로고
    • Basal cytokeratin phenotypes of myoepithelial cells indicates the origin of ductal carcinomas in situ of the breast
    • Chen L, Yin X, Lu S, Chen G, Dong L. Basal cytokeratin phenotypes of myoepithelial cells indicates the origin of ductal carcinomas in situ of the breast. Appl Immunohistochem Mol Morphol 2015; 23:558-64.
    • (2015) Appl Immunohistochem Mol Morphol , vol.23 , pp. 558-564
    • Chen, L.1    Yin, X.2    Lu, S.3    Chen, G.4    Dong, L.5
  • 85
    • 84942198941 scopus 로고    scopus 로고
    • High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy
    • Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman ML, et al. High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. Mol Oncol 2015; 9:1636-54.
    • (2015) Mol Oncol , vol.9 , pp. 1636-1654
    • Gromova, I.1    Gromov, P.2    Honma, N.3    Kumar, S.4    Rimm, D.5    Talman, M.L.6
  • 86
    • 84923882200 scopus 로고    scopus 로고
    • The differences in ultrasound and clinicopathological features between basal-like and normal-like subtypes of triple negative breast cancer
    • Li Z, Ren M, Tian J, Jiang S, Liu Y, Zhang L, et al. The differences in ultrasound and clinicopathological features between basal-like and normal-like subtypes of triple negative breast cancer. PLoS One 2015; 10: e0114820.
    • (2015) PLoS One , vol.10
    • Li, Z.1    Ren, M.2    Tian, J.3    Jiang, S.4    Liu, Y.5    Zhang, L.6
  • 87
    • 84966473543 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer
    • Epub 2016 Mar 22
    • Hyun KA, Goo KB, Han H, Sohn J, Choi W, Kim SI, et al. Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer. Oncotarget. Epub 2016 Mar 22. http://dx.doi.org/10.18632/ oncotarget.8250.
    • Oncotarget
    • Hyun, K.A.1    Goo, K.B.2    Han, H.3    Sohn, J.4    Choi, W.5    Kim, S.I.6
  • 88
    • 0037463230 scopus 로고    scopus 로고
    • Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival
    • Spizzo G, Gastl G, Wolf D, Gunsilius E, Steurer M, Fong D, et al. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. Br J Cancer 2003; 88:574-8.
    • (2003) Br J Cancer , vol.88 , pp. 574-578
    • Spizzo, G.1    Gastl, G.2    Wolf, D.3    Gunsilius, E.4    Steurer, M.5    Fong, D.6
  • 89
    • 0033398990 scopus 로고    scopus 로고
    • Monoclonal antibody therapy with edrecolomab in breast cancer patients: Monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow
    • Braun S, Hepp F, Kentenich CR, Janni W, Pantel K, Riethmüller G, et al. Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow. Clin Cancer Res 1999; 5:3999-4004.
    • (1999) Clin Cancer Res , vol.5 , pp. 3999-4004
    • Braun, S.1    Hepp, F.2    Kentenich, C.R.3    Janni, W.4    Pantel, K.5    Riethmüller, G.6
  • 90
    • 84959515208 scopus 로고    scopus 로고
    • Survival of breast cancer patients according to changes in expression of selected markers between primary tumor and lymph node metastases
    • Adamczyk A, Niemiec J, Ambicka A, Mucha-Małecka A, Ryś J, Mituś J, et al. Survival of breast cancer patients according to changes in expression of selected markers between primary tumor and lymph node metastases. Biomark Med 2016; 10:219-28.
    • (2016) Biomark Med , vol.10 , pp. 219-228
    • Adamczyk, A.1    Niemiec, J.2    Ambicka, A.3    Mucha-Małecka, A.4    Ryś, J.5    Mituś, J.6
  • 91
    • 84905022679 scopus 로고    scopus 로고
    • CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK
    • Lim J, Lee KM, Shim J, Shin I. CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK. Arch Biochem Biophys 2014; 558:120-6.
    • (2014) Arch Biochem Biophys , vol.558 , pp. 120-126
    • Lim, J.1    Lee, K.M.2    Shim, J.3    Shin, I.4
  • 92
    • 84959324589 scopus 로고    scopus 로고
    • CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells
    • Suyama K, Onishi H, Imaizumi A, Shinkai K, Umebayashi M, Kubo M, et al. CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells. Cancer Lett 2016; 374:44-53.
    • (2016) Cancer Lett , vol.374 , pp. 44-53
    • Suyama, K.1    Onishi, H.2    Imaizumi, A.3    Shinkai, K.4    Umebayashi, M.5    Kubo, M.6
  • 93
    • 85012977518 scopus 로고    scopus 로고
    • Predictive value of CD44 and CD24 for prognosis and chemotherapy response in invasive breast ductal carcinoma
    • Chen Y, Song J, Jiang Y, Yu C, Ma Z. Predictive value of CD44 and CD24 for prognosis and chemotherapy response in invasive breast ductal carcinoma. Int J Clin Exp Pathol 2015; 8:11287-95.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 11287-11295
    • Chen, Y.1    Song, J.2    Jiang, Y.3    Yu, C.4    Ma, Z.5
  • 94
    • 84961959080 scopus 로고    scopus 로고
    • CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel
    • Muntimadugu E, Kumar R, Saladi S, Rafeeqi TA, Khan W. CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel. Colloids Surf B Biointerfaces 2016; 143:532-46.
    • (2016) Colloids Surf B Biointerfaces , vol.143 , pp. 532-546
    • Muntimadugu, E.1    Kumar, R.2    Saladi, S.3    Rafeeqi, T.A.4    Khan, W.5
  • 95
    • 84874658093 scopus 로고    scopus 로고
    • Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types
    • de Beça FF, Caetano P, Gerhard R, Alvarenga CA, Gomes M, Paredes J, et al. Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types. J Clin Pathol 2013; 66:187-91.
    • (2013) J Clin Pathol , vol.66 , pp. 187-191
    • de Beça, F.F.1    Caetano, P.2    Gerhard, R.3    Alvarenga, C.A.4    Gomes, M.5    Paredes, J.6
  • 96
    • 84955493784 scopus 로고    scopus 로고
    • Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis
    • Xu H, Tian Y, Yuan X, Liu Y, Wu H, Liu Q, et al. Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis. Onco Targets Ther 2016; 9:431-44.
    • (2016) Onco Targets Ther , vol.9 , pp. 431-444
    • Xu, H.1    Tian, Y.2    Yuan, X.3    Liu, Y.4    Wu, H.5    Liu, Q.6
  • 97
    • 84957660724 scopus 로고    scopus 로고
    • New findings on breast cancer stem cells: A review
    • Bozorgi A, Khazaei M, Khazaei MR. New findings on breast cancer stem cells: a review. J Breast Cancer 2015; 18:303-12.
    • (2015) J Breast Cancer , vol.18 , pp. 303-312
    • Bozorgi, A.1    Khazaei, M.2    Khazaei, M.R.3
  • 98
    • 84875204974 scopus 로고    scopus 로고
    • Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues
    • Ghosh SK, Pantazopoulos P, Medarova Z, Moore A. Expression of underglycosylated MUC1 antigen in cancerous and adjacent normal breast tissues. Clin Breast Cancer 2013; 13:109-18.
    • (2013) Clin Breast Cancer , vol.13 , pp. 109-118
    • Ghosh, S.K.1    Pantazopoulos, P.2    Medarova, Z.3    Moore, A.4
  • 99
    • 84898014554 scopus 로고    scopus 로고
    • MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition
    • Rajabi H, Alam M, Takahashi H, Kharbanda A, Guha M, Ahmad R, et al. MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 2014; 33:1680-9.
    • (2014) Oncogene , vol.33 , pp. 1680-1689
    • Rajabi, H.1    Alam, M.2    Takahashi, H.3    Kharbanda, A.4    Guha, M.5    Ahmad, R.6
  • 100
    • 84930895123 scopus 로고    scopus 로고
    • MUC1-mediated motility in breast cancer: A review highlighting the role of the MUC1/ICAM-1/Src signaling triad
    • Haddon L, Hugh J. MUC1-mediated motility in breast cancer: a review highlighting the role of the MUC1/ICAM-1/Src signaling triad. Clin Exp Metastasis 2015; 32:393-403.
    • (2015) Clin Exp Metastasis , vol.32 , pp. 393-403
    • Haddon, L.1    Hugh, J.2
  • 101
    • 84930226290 scopus 로고    scopus 로고
    • Immunoreactivity of the fully humanized therapeutic antibody PankoMab-GEX™ is an independent prognostic marker for breast cancer patients
    • Heublein S, Mayr D, Egger M, Karsten U, Goletz S, Angele M, et al. Immunoreactivity of the fully humanized therapeutic antibody PankoMab-GEX™ is an independent prognostic marker for breast cancer patients. J Exp Clin Cancer Res 2015; 34:50.
    • (2015) J Exp Clin Cancer Res , vol.34 , pp. 50
    • Heublein, S.1    Mayr, D.2    Egger, M.3    Karsten, U.4    Goletz, S.5    Angele, M.6
  • 102
    • 84901396865 scopus 로고    scopus 로고
    • Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells
    • Raina D, Uchida Y, Kharbanda A, Rajabi H, Panchamoorthy G, Jin C, et al. Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells. Oncogene 2014; 33:3422-31.
    • (2014) Oncogene , vol.33 , pp. 3422-3431
    • Raina, D.1    Uchida, Y.2    Kharbanda, A.3    Rajabi, H.4    Panchamoorthy, G.5    Jin, C.6
  • 103
    • 0032173668 scopus 로고    scopus 로고
    • Expression of BRCA1 and BRCA2 in normal and neoplastic cells
    • Chodosh LA. Expression of BRCA1 and BRCA2 in normal and neoplastic cells. J Mammary Gland Biol Neoplasia 1998; 3:389-402.
    • (1998) J Mammary Gland Biol Neoplasia , vol.3 , pp. 389-402
    • Chodosh, L.A.1
  • 104
    • 27744502545 scopus 로고    scopus 로고
    • Spectrum of breast cancer metastasis in BRCA1 mutation carriers: Highly increased incidence of brain metastases
    • Albiges L, André F, Balleyguier C, Gomez-Abuin G, Chompret A, Delaloge S. Spectrum of breast cancer metastasis in BRCA1 mutation carriers: highly increased incidence of brain metastases. Ann Oncol 2005; 16:1846-7.
    • (2005) Ann Oncol , vol.16 , pp. 1846-1847
    • Albiges, L.1    André, F.2    Balleyguier, C.3    Gomez-Abuin, G.4    Chompret, A.5    Delaloge, S.6
  • 105
    • 84962146880 scopus 로고    scopus 로고
    • Examining the relationship between pre-malignant breast lesions, carcinogenesis and tumor evolution in the mammary epithelium using an agent-based model
    • Chapa J, An G, Kulkarni SA. Examining the relationship between pre-malignant breast lesions, carcinogenesis and tumor evolution in the mammary epithelium using an agent-based model. PLoS One 2016; 11:e0152298.
    • (2016) PLoS One , vol.11
    • Chapa, J.1    An, G.2    Kulkarni, S.A.3
  • 106
    • 77449112686 scopus 로고    scopus 로고
    • Key signalling nodes in mammary gland development and cancer: Myc
    • Hynes NE, Stoelzle T. Key signalling nodes in mammary gland development and cancer: Myc. Breast Cancer Res 2009; 11:210.
    • (2009) Breast Cancer Res , vol.11 , pp. 210
    • Hynes, N.E.1    Stoelzle, T.2
  • 107
    • 84960192910 scopus 로고    scopus 로고
    • MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours
    • Green AR, Aleskandarany MA, Agarwal D, Elsheikh S, Nolan CC, Diez-Rodriguez M, et al. MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours. Br J Cancer 2016; 114:917-28.
    • (2016) Br J Cancer , vol.114 , pp. 917-928
    • Green, A.R.1    Aleskandarany, M.A.2    Agarwal, D.3    Elsheikh, S.4    Nolan, C.C.5    Diez-Rodriguez, M.6
  • 108
    • 84892623048 scopus 로고    scopus 로고
    • Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness
    • Bocca C, Ievolella M, Autelli R, Motta M, Mosso L, Torchio B, et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin Ther Targets 2014; 18:121-35.
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 121-135
    • Bocca, C.1    Ievolella, M.2    Autelli, R.3    Motta, M.4    Mosso, L.5    Torchio, B.6
  • 109
    • 84894443593 scopus 로고    scopus 로고
    • COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro
    • Du Y, Shi A, Han B, Li S, Wu D, Jia H, et al. COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro. Int J Oncol 2014; 44:1385-93.
    • (2014) Int J Oncol , vol.44 , pp. 1385-1393
    • Du, Y.1    Shi, A.2    Han, B.3    Li, S.4    Wu, D.5    Jia, H.6
  • 110
    • 85048775182 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) and regulation of EMT factors by steroid nuclear receptors in breast cancer: A review and in silico investigation
    • Voutsadakis IA. Epithelial-mesenchymal transition (EMT) and regulation of EMT factors by steroid nuclear receptors in breast cancer: a review and in silico investigation. J Clin Med 2016; 5:11.
    • (2016) J Clin Med , vol.5 , pp. 11
    • Voutsadakis, I.A.1
  • 111
    • 84879488869 scopus 로고    scopus 로고
    • Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis
    • Curtit E, Nerich V, Mansi L, Chaigneau L, Cals L, Villanueva C, et al. Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis. Oncologist 2013; 18:667-74.
    • (2013) Oncologist , vol.18 , pp. 667-674
    • Curtit, E.1    Nerich, V.2    Mansi, L.3    Chaigneau, L.4    Cals, L.5    Villanueva, C.6
  • 112
    • 84982843867 scopus 로고    scopus 로고
    • Overcoming resistance to endocrine therapy in breast cancer: New approaches to a nagging problem
    • Epub 2016 Feb 5
    • Luqmani YA, Alam-Eldin N. Overcoming resistance to endocrine therapy in breast cancer: new approaches to a nagging problem. Med Princ Pract. Epub 2016 Feb 5. http://dx.doi.org/10.1159/000444451.
    • Med Princ Pract
    • Luqmani, Y.A.1    Alam-Eldin, N.2
  • 113
    • 84955311817 scopus 로고    scopus 로고
    • Taxanes versus S-1 as the first-line chemotherapy for metastatic breast cancer (SELECT BC): An open-label, non-inferiority, randomised phase 3 trial
    • Takashima T, Mukai H, Hara F, Matsubara N, Saito T, Takano T, et al. Taxanes versus S-1 as the first-line chemotherapy for metastatic breast cancer (SELECT BC): an open-label, non-inferiority, randomised phase 3 trial. Lancet Oncol 2016; 17:90-8.
    • (2016) Lancet Oncol , vol.17 , pp. 90-98
    • Takashima, T.1    Mukai, H.2    Hara, F.3    Matsubara, N.4    Saito, T.5    Takano, T.6
  • 114
    • 84906059815 scopus 로고    scopus 로고
    • Expression of androgen receptor and its association with estrogen receptor and androgen receptor downstream proteins in normal/benign breast luminal epithelium
    • Wang X, Yarid N, McMahon L, Yang Q, Hicks DG. Expression of androgen receptor and its association with estrogen receptor and androgen receptor downstream proteins in normal/benign breast luminal epithelium. Appl Immunohistochem Mol Morphol 2014; 22:498-504.
    • (2014) Appl Immunohistochem Mol Morphol , vol.22 , pp. 498-504
    • Wang, X.1    Yarid, N.2    McMahon, L.3    Yang, Q.4    Hicks, D.G.5
  • 115
    • 84962219456 scopus 로고    scopus 로고
    • Androgen receptor and metastasis-associated protein-1 are frequently expressed in estrogen receptor negative/HER2 positive breast cancer
    • Zhao L, Niu F, Shen H, Liu X, Chen L, Niu Y. Androgen receptor and metastasis-associated protein-1 are frequently expressed in estrogen receptor negative/HER2 positive breast cancer. Virchows Arch 2016; 468:687-96.
    • (2016) Virchows Arch , vol.468 , pp. 687-696
    • Zhao, L.1    Niu, F.2    Shen, H.3    Liu, X.4    Chen, L.5    Niu, Y.6
  • 116
    • 84961575305 scopus 로고    scopus 로고
    • Role of the androgen receptor in triple-negative breast cancer
    • Rampurwala M, Wisinski KB, O'Regan R. Role of the androgen receptor in triple-negative breast cancer. Clin Adv Hematol Oncol 2016; 14: 186-93.
    • (2016) Clin Adv Hematol Oncol , vol.14 , pp. 186-193
    • Rampurwala, M.1    Wisinski, K.B.2    O'Regan, R.3
  • 117
    • 84934757075 scopus 로고    scopus 로고
    • Androgen receptor and enzymes in lymph node metastasis and cancer reoccurrence in triple-negative breast cancer
    • McNamara KM, Yoda T, Miki Y, Nakamura Y, Suzuki T, Nemoto N, et al. Androgen receptor and enzymes in lymph node metastasis and cancer reoccurrence in triple-negative breast cancer. Int J Biol Markers 2015; 30:e184-9.
    • (2015) Int J Biol Markers , vol.30 , pp. e184-e189
    • McNamara, K.M.1    Yoda, T.2    Miki, Y.3    Nakamura, Y.4    Suzuki, T.5    Nemoto, N.6
  • 119
    • 84928005686 scopus 로고    scopus 로고
    • EMT transition alters interstitial fluid flow-induced signaling in ERBB2-positive breast cancer cells
    • Tchafa AM, Ta M, Reginato MJ, Shieh AC. EMT transition alters interstitial fluid flow-induced signaling in ERBB2-positive breast cancer cells. Mol Cancer Res 2015; 13:755-64.
    • (2015) Mol Cancer Res , vol.13 , pp. 755-764
    • Tchafa, A.M.1    Ta, M.2    Reginato, M.J.3    Shieh, A.C.4
  • 120
    • 84947745248 scopus 로고    scopus 로고
    • Clinicopathologic significance of the intratumoral heterogeneity of HER2 gene amplification in HER2-positive breast cancer patients treated with adjuvant trastuzumab
    • Lee HJ, Kim JY, Park SY, Park IA, Song IH, Yu JH, et al. Clinicopathologic significance of the intratumoral heterogeneity of HER2 gene amplification in HER2-positive breast cancer patients treated with adjuvant trastuzumab. Am J Clin Pathol 2015; 144:570-8.
    • (2015) Am J Clin Pathol , vol.144 , pp. 570-578
    • Lee, H.J.1    Kim, J.Y.2    Park, S.Y.3    Park, I.A.4    Song, I.H.5    Yu, J.H.6
  • 121
    • 84928668603 scopus 로고    scopus 로고
    • Correlation between p53 and epidermal growth factor receptor expression in breast cancer classification
    • Wang XZ, Liu Q, Sun JJ, Zuo WS, Hu DW, Ma SG, et al. Correlation between p53 and epidermal growth factor receptor expression in breast cancer classification. Genet Mol Res 2015; 14:4282-90.
    • (2015) Genet Mol Res , vol.14 , pp. 4282-4290
    • Wang, X.Z.1    Liu, Q.2    Sun, J.J.3    Zuo, W.S.4    Hu, D.W.5    Ma, S.G.6
  • 122
    • 84964694939 scopus 로고    scopus 로고
    • The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6
    • Wendt MK, Williams WK, Pascuzzi PE, Balanis NG, Schiemann BJ, Carlin CR, et al. The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. Neoplasia 2015; 17: 124-33.
    • (2015) Neoplasia , vol.17 , pp. 124-133
    • Wendt, M.K.1    Williams, W.K.2    Pascuzzi, P.E.3    Balanis, N.G.4    Schiemann, B.J.5    Carlin, C.R.6
  • 123
    • 84954403089 scopus 로고    scopus 로고
    • Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells
    • Tanei T, Choi DS, Rodriguez AA, Liang DH, Dobrolecki L, Ghosh M, et al. Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells. Breast Cancer Res 2016; 18:6.
    • (2016) Breast Cancer Res , vol.18 , pp. 6
    • Tanei, T.1    Choi, D.S.2    Rodriguez, A.A.3    Liang, D.H.4    Dobrolecki, L.5    Ghosh, M.6
  • 125
    • 65449119185 scopus 로고    scopus 로고
    • Anti-EGFR therapy: Mechanism and advances in clinical efficacy in breast cancer
    • Flynn JF, Wong C, Wu JM. Anti-EGFR therapy: mechanism and advances in clinical efficacy in breast cancer. J Oncol 2009; 2009:526963.
    • (2009) J Oncol , vol.2009
    • Flynn, J.F.1    Wong, C.2    Wu, J.M.3
  • 126
    • 74549210351 scopus 로고    scopus 로고
    • Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer
    • Tevaarwerk AJ, Kolesar JM. Lapatinib: a small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer. Clin Ther 2009; 31 Pt 2:2332-48.
    • (2009) Clin Ther , vol.31 , pp. 2332-2348
    • Tevaarwerk, A.J.1    Kolesar, J.M.2
  • 127
    • 84963606510 scopus 로고    scopus 로고
    • The association between EGFR and cMET expression and phosphorylation and its prognostic implication in patients with breast cancer
    • Chae YK, Gagliato Dde M, Pai SG, Carneiro B, Mohindra N, Giles FJ, et al. The association between EGFR and cMET expression and phosphorylation and its prognostic implication in patients with breast cancer. PLoS One 2016; 11:e0152585.
    • (2016) PLoS One , vol.11
    • Chae, Y.K.1    Gagliato Dde, M.2    Pai, S.G.3    Carneiro, B.4    Mohindra, N.5    Giles, F.J.6
  • 128
    • 84934949710 scopus 로고    scopus 로고
    • Constitutive expression of Bcl-2 induces epithelial-Mesenchymal transition in mammary epithelial cells
    • An J, Lv J, Li A, Qiao J, Fang L, Li Z, et al. Constitutive expression of Bcl-2 induces epithelial-Mesenchymal transition in mammary epithelial cells. BMC Cancer 2015; 15:476.
    • (2015) BMC Cancer , vol.15 , pp. 476
    • An, J.1    Lv, J.2    Li, A.3    Qiao, J.4    Fang, L.5    Li, Z.6
  • 129
    • 84903856573 scopus 로고    scopus 로고
    • Positive immunohistochemical expression of bcl-2 in hormone-independent breast carcinomas is associated with a greater lymph node involvement and poor outcome
    • Ruibal Á, Aguiar P, Del Río MC, Menéndez P, Arias JI, Herranz M. Positive immunohistochemical expression of bcl-2 in hormone-independent breast carcinomas is associated with a greater lymph node involvement and poor outcome. Med Oncol 2014; 31:105.
    • (2014) Med Oncol , vol.31 , pp. 105
    • Ruibal, Á.1    Aguiar, P.2    Del Río, M.C.3    Menéndez, P.4    Arias, J.I.5    Herranz, M.6
  • 130
    • 84921646738 scopus 로고    scopus 로고
    • Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2-and c-FLIP-overexpressing breast carcinoma cells
    • Choi JE, Woo SM, Min KJ, Kang SH, Lee SJ, Kwon TK. Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2-and c-FLIP-overexpressing breast carcinoma cells. Oncol Rep 2015; 33: 1395-401.
    • (2015) Oncol Rep , vol.33 , pp. 1395-1401
    • Choi, J.E.1    Woo, S.M.2    Min, K.J.3    Kang, S.H.4    Lee, S.J.5    Kwon, T.K.6
  • 131
    • 84872075127 scopus 로고    scopus 로고
    • Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer
    • Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM. Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer. Exp Oncol 2012; 34:192-9.
    • (2012) Exp Oncol , vol.34 , pp. 192-199
    • Weyhenmeyer, B.1    Murphy, A.C.2    Prehn, J.H.3    Murphy, B.M.4
  • 132
    • 70349191932 scopus 로고    scopus 로고
    • Analysis of the immunohistochemical expression of mammaglobin A in primary breast carcinoma and lymph node metastasis
    • Raica M, Cîmpean AM, Meche A, Alexa A, Suciu C, Mureşan A. Analysis of the immunohistochemical expression of mammaglobin A in primary breast carcinoma and lymph node metastasis. Rom J Morphol Embryol 2009; 50:341-7.
    • (2009) Rom J Morphol Embryol , vol.50 , pp. 341-347
    • Raica, M.1    Cîmpean, A.M.2    Meche, A.3    Alexa, A.4    Suciu, C.5    Mureşan, A.6
  • 133
    • 84969144825 scopus 로고    scopus 로고
    • Human mammaglobin: A specific marker for breast cancer prognosis
    • Li C, Zhang T. Human mammaglobin: a specific marker for breast cancer prognosis. J BUON 2016; 21:35-41.
    • (2016) J BUON , vol.21 , pp. 35-41
    • Li, C.1    Zhang, T.2
  • 134
    • 84937807406 scopus 로고    scopus 로고
    • Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs
    • Picot N, Guerrette R, Beauregard AP, Jean S, Michaud P, Harquail J, et al. Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs. Mol Carcinog 2016; 55:1150-62.
    • (2016) Mol Carcinog , vol.55 , pp. 1150-1162
    • Picot, N.1    Guerrette, R.2    Beauregard, A.P.3    Jean, S.4    Michaud, P.5    Harquail, J.6
  • 136
    • 77955063129 scopus 로고    scopus 로고
    • Detection of circulating tumour cells in breast cancer patients using human mammaglobin RT-PCR: Association with clinical prognostic factors
    • Ferro P, Franceschini MC, Bacigalupo B, Dessanti P, Falco E, Fontana V, et al. Detection of circulating tumour cells in breast cancer patients using human mammaglobin RT-PCR: association with clinical prognostic factors. Anticancer Res 2010; 30:2377-82.
    • (2010) Anticancer Res , vol.30 , pp. 2377-2382
    • Ferro, P.1    Franceschini, M.C.2    Bacigalupo, B.3    Dessanti, P.4    Falco, E.5    Fontana, V.6
  • 137
    • 85000796440 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition phenotype is associated with clinicopathological factors that indicate aggressive biological behavior and poor clinical outcomes in invasive breast cancer
    • Bae YK, Choi JE, Kang SH, Lee SJ. Epithelial-mesenchymal transition phenotype is associated with clinicopathological factors that indicate aggressive biological behavior and poor clinical outcomes in invasive breast cancer. J Breast Cancer 2015; 18:256-63.
    • (2015) J Breast Cancer , vol.18 , pp. 256-263
    • Bae, Y.K.1    Choi, J.E.2    Kang, S.H.3    Lee, S.J.4
  • 138
    • 84879486621 scopus 로고    scopus 로고
    • Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP pathways
    • Brouxhon SM, Kyrkanides S, Teng X, Raja V, O'Banion MK, Clarke R, et al. Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways. Clin Cancer Res 2013; 19: 3234-46.
    • (2013) Clin Cancer Res , vol.19 , pp. 3234-3246
    • Brouxhon, S.M.1    Kyrkanides, S.2    Teng, X.3    Raja, V.4    O'Banion, M.K.5    Clarke, R.6
  • 139
    • 84891724540 scopus 로고    scopus 로고
    • Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinoma
    • Pula B, Wojnar A, Witkiewicz W, Dziegiel P, Podhorska-Okolow M. Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinoma. Neoplasma 2013; 60:516-24.
    • (2013) Neoplasma , vol.60 , pp. 516-524
    • Pula, B.1    Wojnar, A.2    Witkiewicz, W.3    Dziegiel, P.4    Podhorska-Okolow, M.5
  • 140
    • 55749085491 scopus 로고    scopus 로고
    • The role of podoplanin in tumor progression and metastasis
    • Raica M, Cimpean AM, Ribatti D. The role of podoplanin in tumor progression and metastasis. Anticancer Res 2008; 28:2997-3006.
    • (2008) Anticancer Res , vol.28 , pp. 2997-3006
    • Raica, M.1    Cimpean, A.M.2    Ribatti, D.3
  • 142
    • 85017330086 scopus 로고    scopus 로고
    • Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity
    • Sriram R, Lo V, Pryce B, Antonova L, Mears AJ, Daneshmand M, et al. Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity. Breast Cancer Res 2015; 17:7.
    • (2015) Breast Cancer Res , vol.17 , pp. 7
    • Sriram, R.1    Lo, V.2    Pryce, B.3    Antonova, L.4    Mears, A.J.5    Daneshmand, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.