Basal cytokeratin phenotypes of myoepithelial cells indicates the origin of ductal carcinomas in situ of the breast

Applied Immunohistochemistry and Molecular Morphology

Volumn 23, Issue 8, 2015, Pages 558-564

  Chen, Ling ^a   Yin, Xiaona ^b   Lu, Shanshan ^c   Chen, Guorong ^c   Dong, Lei ^c,d  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b Jiaxing Maternity and Child Health Care Hospital   (China)

^c THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

basal cytokeratin; breast; ductal carcinoma in situ; myoepithelial cell

Indexed keywords

CALPONIN; CYTOKERATIN; CYTOKERATIN 14; CYTOKERATIN 17; CYTOKERATIN 5; CYTOKERATIN 6; PROTEIN P63; ACTIN; ACTIN BINDING PROTEIN; CALCIUM BINDING PROTEIN; KERATIN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST DISEASE; BREAST SCLEROSING ADENOSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MYOEPITHELIUM CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; USUAL DUCTAL HYPERPLASIA; BREAST TUMOR; FEMALE; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY;

ACTINS; ADULT; BREAST NEOPLASMS; CALCIUM-BINDING PROTEINS; CARCINOMA, DUCTAL; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; MICROFILAMENT PROTEINS; MIDDLE AGED; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84942235165     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0000000000000123     Document Type: Article

References (21)

1. Barsky SH. Myoepithelial mRNA expression profiling reveals a common tumor suppressor phenotype. Exp Mol Pathol. 2003; 74:113-122.
2. Allinen M, Beroukhim R, Cai L, et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004;6:17-32.
3. Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in ductal carcinoma in situassociated myoepithelial cells: biologic and diagnostic implications. Am J Surg Pathol. 2009;33:227-232.
4. Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol. 2010;34:896-900.
5. Adriance MC, Inman JL, Petersen OW, et al. Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. 2005;7:190-197.
6. Gudjonsson T, Ronnov-Jessen L, Villadsen R, et al. Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci. 2002;115:39-50.
7. Gusterson BA, Ross DT, Heath VJ, et al. Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res. 2005;7:143-148.
8. Petersen OW, Polyak K. Stem cells in the human breast. Cold Spring Harb Perspect. 2010;2:a003160.
9. Yeh IT, Mies C. Application of immunohistochemistry to breast lesions. Arch Pathol Lab Med. 2008;132:349-358.
10. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406:747-752.
11. Boecker W, Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif. 2003;36(suppl 1):73-84.
12. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO Classification of Tumours of the Breast. Lyon: IARC; 2012:81-115.
13. Battifora H. Assessment of antigen damage in immunohistochemistry: the vimentin internal control. Am J Clin Pathol. 1991;96: 669-671.
14. Wellings SR. A hypothesis of the origin of human breast cancer from the terminal ductal lobular unit. Pathol Res Pract. 1980;166:515-535.
15. Polyak K, Hu M. Do myoepithelial cells hold the key for breast tumor progression? J Mammary Gland Bio Neoplasia. 2005;10: 231-247.
16. Pechoux C, Gudjonsson T, Ronnov-Jessen L, et al. Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev Biol. 1999;206:88-99.
17. Wetzels RH, Kuijpers HJ, Lane EB, et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol. 1991;138:751-763.
18. Going JJ. Normal breast. In: OMalley FP, Pinder SE, eds. Breast Pathology. 1st ed. Philadelphia: Churchill Livingstone Elsevier; 2006:62-64.
19. Bankfalvi A, Ludwig A, de-Hesselle B, et al. Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases. Mod Pathol. 2004;17:1051-1061.
20. Simpson PT, Reis-Filho JS, Gale T, et al. Molecular evolution of breast cancer. J Pathol. 2005;205:248-254.
21. Moll R, Krepler R, Franke WW. Complex cytokeratin polypeptide patterns observed in certain human carcinomas. Differentiation. 1983;23:256-269.