Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic

Journal of Pathology

Volumn 231, Issue 4, 2013, Pages 457-465

  Al Rakan, Maha A ^a   Colak, Dilek ^a   Hendrayani, Siti Faujiah ^a   Al Bakheet, Albandary ^a   Al Mohanna, Falah H ^a   Kaya, Namik ^a   Al Malik, Osama ^a   Aboussekhra, Abdelilah ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

breast cancer; epithelial to mesenchymal transition; gene expression; stromal fibroblasts

Indexed keywords

CYCLINE; CYTOKINE; GELATINASE A; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CELL; BREAST EPITHELIUM; BREAST RECONSTRUCTION; CANCER PATIENT; CARCINOGENICITY; CELL MIGRATION; CELL PROLIFERATION; CELLULAR PARAMETERS; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; STROMA CELL; TUMOR GROWTH;

BREAST CANCER; EPITHELIAL-TO-MESENCHYMAL TRANSITION; GENE EXPRESSION; STROMAL FIBROBLASTS;

ANIMALS; BREAST NEOPLASMS; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHEMOKINE CXCL12; CYTOKINES; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; HETEROGRAFTS; HUMANS; INTERLEUKIN-6; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STROMAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84887557103     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4256     Document Type: Article

References (34)

1. Arendt LM, Rudnick JA, Keller PJ, et al., Stroma in breast development and disease. Semin Cell Dev Biol 2009; 21: 11-18.
2. Polyak K, Kalluri R,. The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol 2010; 2010: doi: 10.1101/cshperspect.a003244.
3. Aboussekhra A., Role of cancer-associated fibroblasts in breast cancer development and prognosis. Int J Dev Biol 2011; 55: 841-849.
4. Polanska UM, Orimo A,. Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol 2013; 228: 1651-1657.
5. Place AE, Jin Huh S, Polyak K. The microenvironment in breast cancer progression: biology and implications for treatment. Breast Cancer Res 2011; 13: 227.
6. Allen M, Jones LJ,. Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J Pathol 2011; 223: 162-176.
7. Xouri G, Christian S,. Origin and function of tumour stroma fibroblasts. Semin Cell Dev Biol 2010; 21: 40-46.
8. Hawsawi NM, Ghebeh H, Hendrayani SF, et al., Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res 2008; 68: 2717-2725.
9. Houssami N, Macaskill P, Marinovich ML, et al., Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy. Eur J Cancer 2010; 46: 3219-3232.
10. Luini A, Rososchansky J, Gatti G, et al., The surgical margin status after breast-conserving surgery: discussion of an open issue. Breast Cancer Res Treat 2009; 113: 397-402.
11. Vaidya JS, Baum M, Tobias JS, et al., Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost. Int J Radiat Oncol Biol Phys 2006; 66: 1335-1338.
12. Belletti B, Vaidya JS, D'Andrea S, et al., Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding. Clin Cancer Res 2008; 14: 1325-1332.
13. Evans A, Whelehan P, Thomson K, et al., Invasive breast cancer: relationship between shear-wave elastographic findings and histologic prognostic factors. Radiology 2012; 263: 673-677.
14. Al-Ansari MM, Hendrayani SF, Shehata AI, et al., p16(INK4A) represses the paracrine tumour-promoting effects of breast stromal fibroblasts. Oncogene 2013; 32: 2356-2364.
15. Reiner A, Yekutieli D, Benjamini Y,. Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 2003; 19: 368-375.
16. -ΔΔCt method. Methods 2001; 25: 402-408.
17. Al-Mohanna MA, Al-Khalaf HH, Al-Yousef N, et al., The p16INK4a tumour suppressor controls p21WAF1 induction in response to ultraviolet light. Nucleic Acids Res 2007; 35: 223-233.
18. Ivanova NB, Dimos JT, Schaniel C, et al., A stem cell molecular signature. Science 2002; 298: 601-604.
19. Dudoit S, Gentleman RC, Quackenbush J,. Open source software for the analysis of microarray data. Biotechniques 2003; 45-51.
20. Kalluri R, Zeisberg M,. Fibroblasts in cancer. Nat Rev Cancer 2006; 6: 392-401.
21. Kojima Y, Acar A, Eaton EN, et al., Autocrine TGFβ and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumour-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 2010; 107: 20009-20014.
22. Orimo A, Gupta PB, Sgroi DC, et al., Stromal fibroblasts present in invasive human breast carcinomas promote tumour growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335-348.
23. Yoeli-Lerner M, Yiu GK, Rabinovitz I, et al., Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005; 20: 539-550.
24. Wiborg O, Pedersen MS, Wind A, et al., The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. EMBO J 1985; 4: 755-759.
25. Ryu KY, Maehr R, Gilchrist CA, et al., The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J 2007; 26: 2693-2706.
26. Fornace AJ Jr, Alamo I Jr, Hollander MC, et al., Ubiquitin mRNA is a major stress-induced transcript in mammalian cells. Nucleic Acids Res 1989; 17: 1215-1230.
27. Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, et al., Understanding the 'lethal' drivers of tumour-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumour micro-environment. Cancer Biol Ther 2010; 10: 537-542.
28. Singer CF, Gschwantler-Kaulich D, Fink-Retter A, et al., Differential gene expression profile in breast cancer-derived stromal fibroblasts. Breast Cancer Res Treat 2008; 110: 273-281.
29. Bauer M, Su G, Casper C, et al., Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene 2010; 29: 1732-1740.
30. Sadlonova A, Bowe DB, Novak Z, et al., Identification of molecular distinctions between normal breast-associated fibroblasts and breast cancer-associated fibroblasts. Cancer Microenviron 2009; 2: 9-21.
31. Pavlides S, Whitaker-Menezes D, Castello-Cros R, et al., The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumour stroma. Cell Cycle 2009; 8: 3984-4001.
32. Vaughan MB, Howard EW, Tomasek JJ,. Transforming growth factor-β1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res 2000; 257: 180-189.
33. Sotgia F, Martinez-Outschoorn UE, Pavlides S, et al., Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumour microenvironment. Breast Cancer Res 2011; 13: 213.
34. Morrow M, Harris JR, Schnitt SJ,. Surgical margins in lumpectomy for breast cancer-bigger is not better. N Engl J Med 2012; 367: 79-82.