메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; DDX58 PROTEIN, MOUSE; PROTEIN TYROSINE KINASE; RETINOIC ACID INDUCIBLE PROTEIN I; STAT3 PROTEIN;

EID: 84976559060     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28914     Document Type: Article
Times cited : (16)

References (52)
  • 2
    • 75549088122 scopus 로고    scopus 로고
    • Goals of treatment for type 2 diabetes: Beta-cell preservation for glycemic control
    • Marchetti, P. et al. Goals of treatment for type 2 diabetes: Beta-cell preservation for glycemic control. Diabetes Care 32 Suppl 2, S178-S183 (2009).
    • (2009) Diabetes Care , vol.32 , pp. S178-S183
    • Marchetti, P.1
  • 3
    • 84897018309 scopus 로고    scopus 로고
    • Toll-like receptor 2/4 links to free fatty acid-induced inflammation and beta-cell dysfunction
    • Yin, J., Peng, Y., Wu, J., Wang, Y. & Yao, L. Toll-like receptor 2/4 links to free fatty acid-induced inflammation and beta-cell dysfunction. J Leukoc Biol 95, 47-52 (2014).
    • (2014) J Leukoc Biol , vol.95 , pp. 47-52
    • Yin, J.1    Peng, Y.2    Wu, J.3    Wang, Y.4    Yao, L.5
  • 4
    • 84893796412 scopus 로고    scopus 로고
    • RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness
    • Li, X. Y. et al. RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Mol Cell. 53, 407-419 (2014).
    • (2014) Mol Cell. , vol.53 , pp. 407-419
    • Li, X.Y.1
  • 5
    • 85006233472 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2
    • Cai, T. et al. Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2. Am J Cancer Res 5, 1610-1620 (2015).
    • (2015) Am J Cancer Res , vol.5 , pp. 1610-1620
    • Cai, T.1
  • 6
    • 84896701751 scopus 로고    scopus 로고
    • Palmitate induces reactive oxygen species production and beta-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling
    • Sato, Y. et al. Palmitate induces reactive oxygen species production and beta-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling. J Diabetes Investig. 5, 19-26 (2014).
    • (2014) J Diabetes Investig. , vol.5 , pp. 19-26
    • Sato, Y.1
  • 7
    • 84988857304 scopus 로고    scopus 로고
    • Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway
    • Alshaker, H. et al. Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway. Breast Cancer Res. 16, 426 (2014).
    • (2014) Breast Cancer Res. , vol.16 , pp. 426
    • Alshaker, H.1
  • 8
    • 84937039220 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces VCAM-1-mediated inflammation via c-Src-dependent transactivation of EGF receptors in human cardiac fibroblasts
    • Lin, C. C. et al. Tumor necrosis factor-alpha induces VCAM-1-mediated inflammation via c-Src-dependent transactivation of EGF receptors in human cardiac fibroblasts. J Biomed Sci. 22, 53 (2015).
    • (2015) J Biomed Sci. , vol.22 , pp. 53
    • Lin, C.C.1
  • 9
    • 84921482984 scopus 로고    scopus 로고
    • Immune complexes suppress IFN-gamma-induced responses in monocytes by activating discrete members of the SRC kinase family
    • Boekhoudt, G. H., McGrath, A. G., Swisher, J. F. & Feldman, G. M. Immune complexes suppress IFN-gamma-induced responses in monocytes by activating discrete members of the SRC kinase family. J Immunol. 194, 983-989 (2015).
    • (2015) J Immunol. , vol.194 , pp. 983-989
    • Boekhoudt, G.H.1    McGrath, A.G.2    Swisher, J.F.3    Feldman, G.M.4
  • 10
    • 84929882548 scopus 로고    scopus 로고
    • The importance of Src signaling in sarcoma
    • Chen, Q. et al. The importance of Src signaling in sarcoma. Oncol Lett. 10, 17-22 (2015).
    • (2015) Oncol Lett. , vol.10 , pp. 17-22
    • Chen, Q.1
  • 11
    • 84936855517 scopus 로고    scopus 로고
    • Rapamycin enhances the Anti-Cancer effect of dasatinib by suppressing Src/PI3K/ mTOR pathway in NSCLC cells
    • Chen, B., Xu, X., Luo, J., Wang, H. & Zhou, S. Rapamycin enhances the Anti-Cancer effect of dasatinib by suppressing Src/PI3K/ mTOR pathway in NSCLC cells. Plos One. 10, e129663 (2015).
    • (2015) Plos One. , vol.10
    • Chen, B.1    Xu, X.2    Luo, J.3    Wang, H.4    Zhou, S.5
  • 12
    • 84946496751 scopus 로고    scopus 로고
    • The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs
    • Zhang, T. et al. The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs. J Mol Histol. 46, 485-497 (2015).
    • (2015) J Mol Histol. , vol.46 , pp. 485-497
    • Zhang, T.1
  • 13
    • 33846268807 scopus 로고    scopus 로고
    • P27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    • Chu, I. et al. P27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell. 128, 281-294 (2007).
    • (2007) Cell , vol.128 , pp. 281-294
    • Chu, I.1
  • 14
    • 84930959009 scopus 로고    scopus 로고
    • Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRalpha/c-SRC/ERK1/2/NFkappaB/TP53 pathway: In vitro and in vivo studies
    • Kuo, C. T., Chang, C. & Lee, W. S. Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRalpha/c-SRC/ERK1/2/NFkappaB/TP53 pathway: In vitro and in vivo studies. Sci Rep. 5, 11187 (2015).
    • (2015) Sci Rep. , vol.5 , pp. 11187
    • Kuo, C.T.1    Chang, C.2    Lee, W.S.3
  • 15
    • 64149112138 scopus 로고    scopus 로고
    • Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src
    • Cen, B., Li, H. & Weinstein, I. B. Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src. J BIOL CHEM. 284, 5265-5276 (2009).
    • (2009) J Biol Chem. , vol.284 , pp. 5265-5276
    • Cen, B.1    Li, H.2    Weinstein, I.B.3
  • 16
    • 77955883766 scopus 로고    scopus 로고
    • Regulation of Skp2 expression and activity and its role in cancer progression
    • Chan, C. H., Lee, S. W., Wang, J. & Lin, H. K. Regulation of Skp2 expression and activity and its role in cancer progression. ScientificWorldJournal. 10, 1001-1015 (2010).
    • (2010) ScientificWorldJournal. , vol.10 , pp. 1001-1015
    • Chan, C.H.1    Lee, S.W.2    Wang, J.3    Lin, H.K.4
  • 17
    • 78649655199 scopus 로고    scopus 로고
    • Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells
    • Chen, J. Y., Wang, M. C. & Hung, W. C. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 226, 407-413 (2011).
    • (2011) J Cell Physiol. , vol.226 , pp. 407-413
    • Chen, J.Y.1    Wang, M.C.2    Hung, W.C.3
  • 18
    • 84873307557 scopus 로고    scopus 로고
    • STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells
    • Wei, Z. et al. STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells. Cell Signal. 25, 931-938 (2013).
    • (2013) Cell Signal. , vol.25 , pp. 931-938
    • Wei, Z.1
  • 19
    • 84874247282 scopus 로고    scopus 로고
    • Implication of inflammatory signaling pathways in obesity-induced insulin resistance
    • Tanti, J. F., Ceppo, F., Jager, J. & Berthou, F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne). 3, 181 (2012).
    • (2012) Front Endocrinol (Lausanne). , vol.3 , pp. 181
    • Tanti, J.F.1    Ceppo, F.2    Jager, J.3    Berthou, F.4
  • 20
    • 84875626061 scopus 로고    scopus 로고
    • Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic beta-cell failure in type 2 diabetes
    • Han, D. et al. Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic beta-cell failure in type 2 diabetes. Genes Cells. 18, 302-314 (2013).
    • (2013) Genes Cells. , vol.18 , pp. 302-314
    • Han, D.1
  • 21
    • 84894375830 scopus 로고    scopus 로고
    • Decreased pattern-recognition receptor-mediated cytokine mRNA expression in obese children with otitis media with effusion
    • Kim, Y. J. et al. Decreased pattern-recognition receptor-mediated cytokine mRNA expression in obese children with otitis media with effusion. Clin Exp Otorhinolaryngol. 7, 7-12 (2014).
    • (2014) Clin Exp Otorhinolaryngol. , vol.7 , pp. 7-12
    • Kim, Y.J.1
  • 22
    • 84891441542 scopus 로고    scopus 로고
    • Expression of innate immunity genes and damage of primary human pancreatic islets by epidemic strains of Echovirus: Implication for post-virus islet autoimmunity
    • Sarmiento, L. et al. Expression of innate immunity genes and damage of primary human pancreatic islets by epidemic strains of Echovirus: Implication for post-virus islet autoimmunity. Plos One. 8, e77850 (2013).
    • (2013) Plos One. , vol.8
    • Sarmiento, L.1
  • 23
    • 84881116306 scopus 로고    scopus 로고
    • Elevated toll-like receptor 3 inhibits pancreatic beta-cell proliferation through G1 phase cell cycle arrest
    • Wang, Y. et al. Elevated toll-like receptor 3 inhibits pancreatic beta-cell proliferation through G1 phase cell cycle arrest. Mol Cell Endocrinol. 377, 112-122 (2013).
    • (2013) Mol Cell Endocrinol. , vol.377 , pp. 112-122
    • Wang, Y.1
  • 24
    • 0035033889 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells
    • Han, X., Sun, Y., Scott, S. & Bleich, D. Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells. Diabetes. 50, 1047-1055 (2001).
    • (2001) Diabetes. , vol.50 , pp. 1047-1055
    • Han, X.1    Sun, Y.2    Scott, S.3    Bleich, D.4
  • 25
    • 70349327410 scopus 로고    scopus 로고
    • Transfection of rat pancreatic islet tissue by polymeric gene vectors
    • Kang, H. C. & Bae, Y. H. Transfection of rat pancreatic islet tissue by polymeric gene vectors. Diabetes Technol Ther. 11, 443-449 (2009).
    • (2009) Diabetes Technol Ther. , vol.11 , pp. 443-449
    • Kang, H.C.1    Bae, Y.H.2
  • 26
    • 84935875147 scopus 로고    scopus 로고
    • Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NFkappaB/ c-Myc Pathway in Pancreatic beta cells
    • Gao, L. et al. Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NFkappaB/ c-Myc Pathway in Pancreatic beta cells. Mol Med. 21, 154-166 (2015).
    • (2015) Mol Med. , vol.21 , pp. 154-166
    • Gao, L.1
  • 27
    • 84883261205 scopus 로고    scopus 로고
    • Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
    • Gu, L. et al. Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi. J Neuroinflammation. 10, 109 (2013).
    • (2013) J Neuroinflammation. , vol.10 , pp. 109
    • Gu, L.1
  • 28
    • 84893695281 scopus 로고    scopus 로고
    • Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic beta-cells
    • Chen, S. S. et al. Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic beta-cells. Biochem Biophys Res Commun. 443, 814-820 (2014).
    • (2014) Biochem Biophys Res Commun. , vol.443 , pp. 814-820
    • Chen, S.S.1
  • 29
    • 57249094223 scopus 로고    scopus 로고
    • Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
    • Meng, Z. X. et al. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52, 125-135 (2009).
    • (2009) Diabetologia. , vol.52 , pp. 125-135
    • Meng, Z.X.1
  • 30
    • 84936889313 scopus 로고    scopus 로고
    • Functional characterizations of IPS-1 in CIK cells: Potential roles in regulating IFN-I response dependent on IRF7 but not IRF3
    • Feng, X. et al. Functional characterizations of IPS-1 in CIK cells: Potential roles in regulating IFN-I response dependent on IRF7 but not IRF3. Dev Comp Immunol. 53, 23-32 (2015).
    • (2015) Dev Comp Immunol. , vol.53 , pp. 23-32
    • Feng, X.1
  • 31
    • 84930677642 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer
    • Min, H. Y. et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Mol Cancer. 14, 113 (2015).
    • (2015) Mol Cancer. , vol.14 , pp. 113
    • Min, H.Y.1
  • 32
    • 84862809754 scopus 로고    scopus 로고
    • Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells
    • Huang, H., Zhao, W. & Yang, D. Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells. Biochem Biophys Res Commun. 418, 186-190 (2012).
    • (2012) Biochem Biophys Res Commun. , vol.418 , pp. 186-190
    • Huang, H.1    Zhao, W.2    Yang, D.3
  • 33
    • 0037160057 scopus 로고    scopus 로고
    • Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
    • Schreiner, S. J., Schiavone, A. P. & Smithgall, T. E. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem. 277, 45680-45687 (2002).
    • (2002) J Biol Chem. , vol.277 , pp. 45680-45687
    • Schreiner, S.J.1    Schiavone, A.P.2    Smithgall, T.E.3
  • 34
    • 44749084179 scopus 로고    scopus 로고
    • Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets
    • Kominato, R. et al. Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets. Diabetologia. 51, 1226-1235 (2008).
    • (2008) Diabetologia. , vol.51 , pp. 1226-1235
    • Kominato, R.1
  • 35
    • 77953196811 scopus 로고    scopus 로고
    • Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes
    • Matsumoto, T., Kobayashi, T., Ishida, K., Taguchi, K. & Kamata, K. Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes. Br J Pharmacol. 160, 1092-1104 (2010).
    • (2010) Br J Pharmacol. , vol.160 , pp. 1092-1104
    • Matsumoto, T.1    Kobayashi, T.2    Ishida, K.3    Taguchi, K.4    Kamata, K.5
  • 36
    • 67349123432 scopus 로고    scopus 로고
    • Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver
    • Gupte, R. S. et al. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic Biol Med. 47, 219-228 (2009).
    • (2009) Free Radic Biol Med. , vol.47 , pp. 219-228
    • Gupte, R.S.1
  • 37
    • 84902455490 scopus 로고    scopus 로고
    • The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion
    • Je, D. W., O, Y. M., Ji, Y. G., Cho, Y. & Lee, D. H. The inhibition of SRC family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion. Pancreas. 43, 768-776 (2014).
    • (2014) Pancreas. , vol.43 , pp. 768-776
    • Je, D.W.1    Ji, Y.G.2    Cho, Y.3    Lee, D.H.4
  • 38
    • 84955708626 scopus 로고    scopus 로고
    • Activated PKR inhibits pancreatic beta-cell proliferation through sumoylation-dependent stabilization of P53
    • Song, Y. et al. Activated PKR inhibits pancreatic beta-cell proliferation through sumoylation-dependent stabilization of P53. Mol Immunol. 68, 341-349 (2015).
    • (2015) Mol Immunol. , vol.68 , pp. 341-349
    • Song, Y.1
  • 39
    • 33645214581 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha enhances influenza a virus-induced expression of antiviral cytokines by activating RIG-I gene expression
    • Matikainen, S. et al. Tumor necrosis factor alpha enhances influenza a virus-induced expression of antiviral cytokines by activating RIG-I gene expression. J Virol. 80, 3515-3522 (2006).
    • (2006) J Virol. , vol.80 , pp. 3515-3522
    • Matikainen, S.1
  • 40
    • 84892152567 scopus 로고    scopus 로고
    • Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic beta-cell dysfunction in polycystic ovary syndrome
    • Malin, S. K., Kirwan, J. P., Sia, C. L. & Gonzalez, F. Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic beta-cell dysfunction in polycystic ovary syndrome. J Clin Endocrinol Metab. 99, 322-329 (2014).
    • (2014) J Clin Endocrinol Metab. , vol.99 , pp. 322-329
    • Malin, S.K.1    Kirwan, J.P.2    Sia, C.L.3    Gonzalez, F.4
  • 41
    • 62449110463 scopus 로고    scopus 로고
    • Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    • Tal, M. C. et al. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 106, 2770-2775 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2770-2775
    • Tal, M.C.1
  • 42
    • 79952389828 scopus 로고    scopus 로고
    • RIG-I-and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes
    • Aida, K. et al. RIG-I-and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes. Diabetes. 60, 884-889 (2011).
    • (2011) Diabetes. , vol.60 , pp. 884-889
    • Aida, K.1
  • 43
    • 84929948203 scopus 로고    scopus 로고
    • PI3K/AKT pathway-mediated regulation of p27(Kip1) is associated with cell cycle arrest and apoptosis in cervical cancer
    • Prasad, S. B. et al. PI3K/AKT pathway-mediated regulation of p27(Kip1) is associated with cell cycle arrest and apoptosis in cervical cancer. Cell Oncol (Dordr). 38, 215-225 (2015).
    • (2015) Cell Oncol (Dordr) , vol.38 , pp. 215-225
    • Prasad, S.B.1
  • 44
    • 84976585964 scopus 로고    scopus 로고
    • Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163
    • Su, L., Han, D., Wu, J. & Huo, X. Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163. Tumour Biol (2015).
    • (2015) Tumour Biol
    • Su, L.1    Han, D.2    Wu, J.3    Huo, X.4
  • 45
    • 84944233791 scopus 로고    scopus 로고
    • SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients
    • Hafez, M. M. et al. SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients. Asian Pac J Cancer Prev. 16, 5807-5815 (2015).
    • (2015) Asian Pac J Cancer Prev. , vol.16 , pp. 5807-5815
    • Hafez, M.M.1
  • 46
    • 84940417040 scopus 로고    scopus 로고
    • P27(Kip1) signaling: Transcriptional and post-translational regulation
    • Hnit, S. S. et al. P27(Kip1) signaling: Transcriptional and post-translational regulation. Int J Biochem Cell Biol. 68, 9-14 (2015).
    • (2015) Int J Biochem Cell Biol , vol.68 , pp. 9-14
    • Hnit, S.S.1
  • 47
    • 77649111171 scopus 로고    scopus 로고
    • A relationship between p27(kip1) and Skp2 after adult brain injury: Implications for glial proliferation
    • Liu, Y. et al. A relationship between p27(kip1) and Skp2 after adult brain injury: Implications for glial proliferation. J Neurotrauma. 27, 361-371 (2010).
    • (2010) J Neurotrauma. , vol.27 , pp. 361-371
    • Liu, Y.1
  • 48
    • 34948821871 scopus 로고    scopus 로고
    • Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells
    • Zhong, L. et al. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest 117, 2869-2876 (2007).
    • (2007) J Clin Invest , vol.117 , pp. 2869-2876
    • Zhong, L.1
  • 49
    • 84927934042 scopus 로고    scopus 로고
    • BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells
    • Lee, J. J. et al. BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells. Cell Death Dis. 5, e1537 (2014).
    • (2014) Cell Death Dis. , vol.5
    • Lee, J.J.1
  • 50
    • 84894456180 scopus 로고    scopus 로고
    • Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2
    • Koo, K. H. et al. Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell Death Dis. 4, e693 (2013).
    • (2013) Cell Death Dis. , vol.4 , pp. e693
    • Koo, K.H.1
  • 51
    • 84875323821 scopus 로고    scopus 로고
    • Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes
    • Kou, Z. Z. et al. Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes. Pain Physician. 16, E71-E83 (2013).
    • (2013) Pain Physician. , vol.16 , pp. E71-E83
    • Kou, Z.Z.1
  • 52
    • 84940373656 scopus 로고    scopus 로고
    • Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways
    • Pan, Q. et al. Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways. J Exp Clin Cancer Res. 34, 77 (2015).
    • (2015) J Exp Clin Cancer Res. , vol.34 , pp. 77
    • Pan, Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.