The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs

Journal of Molecular Histology

Volumn 46, Issue 6, 2015, Pages 485-497

  Zhang, Tingting ^a   Wan, Chunhua ^b   Shi, Weidong ^c   Xu, Jian ^c   Fan, Hui ^c   Zhang, Shusen ^a   Lin, Zhipeng ^a   Ni, Runzhou ^a   Zhang, Xiubing ^c  

^a NANTONG UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

^c The Second People's Hospital of Nantong   (China)

Author keywords

FOXOs; Hepatocellular carcinoma; p27kip1; RNA binding protein; Sam68

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; HEPATITIS B SURFACE ANTIGEN; KI 67 ANTIGEN; PROTEIN KINASE B; PROTEIN P27; PROTEIN SAM68; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXO; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; KHDRBS1 PROTEIN, HUMAN; RNA BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ANTIGEN EXPRESSION; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SIZE; CANCER SURVIVAL; CARCINOGENICITY; CELL PROLIFERATION; CELL VIABILITY; CLINICAL FEATURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER NODULE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; SIGNAL TRANSDUCTION; STARVATION; SURVIVAL RATE; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR CELL; UPREGULATION; AGED; APOPTOSIS; CANCER STAGING; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL SURVIVAL; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LIVER TUMOR; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; KI-67 ANTIGEN; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-AKT; RNA-BINDING PROTEINS; TRANSCRIPTIONAL ACTIVATION;

EID: 84946496751     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-015-9639-y     Document Type: Article

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