RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates β-cell death in fulminant type 1 diabetes

Diabetes

Volumn 60, Issue 3, 2011, Pages 884-889

  Aida, Kaoru ^a   Nishida, Yoriko ^a   Tanaka, Shoichiro ^a   Maruyama, Taro ^b   Shimada, Akira ^c   Awata, Takuya ^d   Suzuki, Masako ^e   Shimura, Hiroki ^a   Takizawa, Soichi ^a   Ichijo, Masashi ^a   Akiyama, Daiichiro ^a   Furuya, Fumihiko ^a   Kawaguchi, Akio ^a   Kaneshige, Masahiro ^a   Itakura, Jun ^a   Fujii, Hideki ^a   Endo, Toyoshi ^a   Kobayashi, Tetsuro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Saitama Social Insurance Hospital   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

^e Sayama Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CASPASE 3; CASPASE 8; CASPASE 9; FAS LIGAND; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 18; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN; PROTEIN MDA5; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; ARTICLE; AUTOPSY; CASE REPORT; CD4+ T LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; DENDRITIC CELL; ENTEROVIRUS INFECTION; GENE OVEREXPRESSION; HUMAN; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MACROPHAGE; MALE; MONONUCLEAR CELL; PANCREAS ISLET BETA CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; CELL DEATH; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS INFECTIONS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; INTERFERON-BETA; INTERFERON-GAMMA; INTERLEUKIN-18; MALE; MIDDLE AGED; TOLL-LIKE RECEPTORS;

EID: 79952389828     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0795     Document Type: Article

References (25)

1. Kobayashi T. Immunology and immunogenetics of type 1 diabetes in Japan. IDF Bull 1990;35:34-37
2. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y; Osaka IDDM Study Group. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 2000; 342:301-307 (Pubitemid 30075242)
3. Tanaka S, Kobayashi T, Momotsu T. A novel subtype of type 1 diabetes mellitus. N Engl J Med 2000;342:1835-1837
4. Tanaka S, Nishida Y, Aida K, et al. Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated betacell failure in fulminant type 1 diabetes. Diabetes 2009;58:2285-2291
5. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol 2008;20:17-22
6. von Herrath M. Diabetes: A virus-gene collaboration. Nature 2009;459:518-519
7. Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005;434:772-777 (Pubitemid 44739521)
8. Sturniolo MT, Dashti SR, Deucher A, et al. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J Biol Chem 2003;278:48066-48073 (Pubitemid 37523257)
9. Sarkar SA, Wong R, Hackl SI, et al. Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes 2007;56:72-79
10. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-389
11. Ylipaasto P, Kutlu B, Rasilainen S, et al. Global profiling of coxsackievirusand cytokine-induced gene expression in human pancreatic islets. Diabetologia 2005;48:1510-1522 (Pubitemid 41175504)
12. Schulte BM, Kramer M, Ansems M, et al. Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes 2010;59:1182-1191
13. Negishi H, Osawa T, Ogami K, et al. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci USA 2008;105:20446-20451
14. Hultcrantz M, Hühn MH, Wolf M, et al. Interferons induce an antiviral state in human pancreatic islet cells. Virology 2007;367:92-101 (Pubitemid 47418925)
15. Le Bon A, Durand V, Kamphuis E, et al. Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J Immunol 2006;176:4682-4689
16. Blanco P, Palucka AK, Pascual V, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008;19:41-52
17. Wei J, Duramad O, Perng OA, Reiner SL, Liu YJ, Qin FX. Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc Natl Acad Sci USA 2007;104: 18169-18174 (Pubitemid 350210839)
18. Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995;378:88-91
19. Pien GC, Nguyen KB, Malmgaard L, Satoskar AR, Biron CA. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 2002;169:5827-5837 (Pubitemid 35291686)
20. Frigerio S, Holländer GA, Zumsteg U. Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitis. Horm Res 2002;57:94-104 (Pubitemid 34507622)
21. Sareneva T, Julkunen I, Matikainen S. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J Immunol 2000;165: 1933-1938 (Pubitemid 30648745)
22. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365 (Pubitemid 27131377)
23. Christen U, Darwiche R, Thomas HE, et al. Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes 2004;53: 591-596 (Pubitemid 38270627)
24. Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001;44:2115-2133 (Pubitemid 34015464)
25. Besch R, Poeck H, Hohenauer T, et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest 2009;119:2399-2411 .