Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling

Journal of Diabetes Investigation

Volumn 5, Issue 1, 2014, Pages 19-26

  Sato, Yuichi ^a   Fujimoto, Shimpei ^a,b   Mukai, Eri ^a   Sato, Hiroki ^a   Tahara, Yumiko ^a   Ogura, Kasane ^a   Yamano, Gen ^a   Ogura, Masahito ^a   Nagashima, Kazuaki ^a   Inagaki, Nobuya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KOCHI UNIVERSITY   (Japan)

Author keywords

Lipotoxicity; Pancreatic cells; Reactive oxygen species

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; PALMITIC ACID; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; GLUCOSE INDUCED INSULIN SECRETION; INSULIN RELEASE; INSULINOMA; ISOLATED PANCREAS ISLET; LIPOTOXICITY; MOUSE STRAIN; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL DYSFUNCTION; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SRC SIGNALING;

EID: 84896701751     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/jdi.12124     Document Type: Article

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