P27Kip1 signaling: Transcriptional and post-translational regulation

International Journal of Biochemistry and Cell Biology

Volumn 68, Issue , 2015, Pages 9-14

  Hnit, Su Su Thae ^a   Xie, Chanlu ^a   Yao, Mu ^b   Holst, Jeff ^c,d   Bensoussan, Alan ^e   De Souza, Paul ^a   Li, Zhong ^f   Dong, Qihan ^a,b  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c CENTENARY INSTITUTE   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e WESTERN SYDNEY UNIVERSITY   (Australia)

^f BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

CRM1; KPC; MYC; p27Kip1; PIRH2; SKP2

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; EXPORTIN 1; METHIONINE; MYC PROTEIN; P53 INDUCED RING H2 TYPE UBIQUITIN LIGASE; PROTEIN KINASE PIM 1; PROTEIN P53; SERINE; THREONINE; TRANSCRIPTION FACTOR FOXO; TYROSINE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE SKP2; UNCLASSIFIED DRUG; KPC PROTEIN, HUMAN; MEN1 PROTEIN, HUMAN; MYC PROTEIN, HUMAN; ONCOPROTEIN; PIM1 PROTEIN, HUMAN; PROTEASOME; S PHASE KINASE ASSOCIATED PROTEIN;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOPLASM; HUMAN; MOLECULAR PATHOLOGY; NONHUMAN; NUCLEAR EXPORT SIGNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PHOSPHORYLATION;

CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS C-PIM-1; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 84940417040     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.08.005     Document Type: Short Survey

References (42)

1. D. Adhikari, W. Zheng, Y. Shen, N. Gorre, Y. Ning, G. Halet, P. Kaldis, and K. Liu Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes Hum. Mol. Genet. 21 11 2012 2476 2484 10.1093/hmg/dds061
2. E. Aleem, H. Kiyokawa, and P. Kaldis Cdc2-cyclin E complexes regulate the G1/S phase transition' Nat. Cell Biol. 7 8 2005 831 836 10.1038/ncb1284
3. A.R. Bahrami, M.M. Matin, and Andrews PW The CDK, inhibitor p27 enhances neural differentiation in pluripotent NTERA2 human EC cells but does not permit differentiation of 2102Ep nullipotent human EC cells Mech. Dev. 122 9 2005 1034 1042 10.1016/j.mod.2005.04.011
4. T. Bondar, A. Kalinina, L. Khair, D. Kopanja, A. Nag, S. Bagchi, and P. Raychaudhuri Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome Mol. Cell. Biol. 26 7 2006 2531 2539 10.1128/mcb.26.7.2531-2539.2006
5. G. Bretones, J.C. Acosta, J.M. Caraballo, N. Ferrandiz, M.T. Gomez-Casares, M. Albajar, R. Blanco, P. Ruiz, W.C. Hung, M.P. Albero, I. Perez-Roger, and J. Leon SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells J. Biol. Chem. 286 11 2011 9815 9825 10.1074/jbc.m110.165977
6. G. Bretones, M.D. Delgado, and J. León Myc and cell cycle control BBA: Gene Regul. Mech. 1849 5 2015 506 516 10.1016/j.bbagrm.2014.03.013
7. V. Chandramohan, N.D. Mineva, B. Burke, S. Jeay, M. Wu, J. Shen, W. Yang, S.R. Hann, and G.E. Sonenshein c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27Kip1 cyclin dependent kinase inhibitor' J. Cell. Biochem. 104 6 2008 2091 2106 10.1002/jcb.21765
8. I. Chu, J. Sun, A. Arnaout, H. Kahn, W. Hanna, S. Narod, P. Sun, C.K. Tan, L. Hengst, and J. Slingerland p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 Cell 128 2 2007 281 294 10.1016/j.cell.2006.11.049
9. I.M. Chu, L. Hengst, and J.M. Slingerland The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy Nat. Rev. Cancer 8 4 2008 253 267 10.1038/nrc2347
10. C. Denicourt, and S.F. Dowdy Cip/Kip proteins: more than just CDKs inhibitors Genes Dev. 18 8 2004 851 855 10.1101/gad.1205304
11. M.L. Fero, M. Rivkin, M. Tasch, P. Porter, C.E. Carow, E. Firpo, K. Polyak, L.H. Tsai, V. Broudy, R.M. Perlmutter, K. Kaushansky, and J.M. Roberts A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice Cell 85 5 1996 733 744 10.1016/s0092-8674(00)81239-8
12. H. Gao, X. Ouyang, W. Banach-Petrosky, A.D. Borowsky, Y. Lin, M. Kim, H. Lee, W.-J. Shih, R.D. Cardiff, and M.M. Shen A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis Proc. Natl. Acad. Sci. U. S. A. 101 49 2004 17204 17209 10.1073/pnas.0407693101
13. M. Grimmler, Y. Wang, T. Mund, Z. Cilensek, E.M. Keidel, M.B. Waddell, H. Jakel, M. Kullmann, R.W. Kriwacki, and L. Hengst Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases Cell 128 2 2007 269 280 10.1016/j.cell.2006.11.047
14. B. Hao, N. Zheng, B.A. Schulman, G. Wu, J.J. Miller, M. Pagano, and N.P. Pavletich Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase Mol. Cell 20 1 2005 9 19 10.1016/j.molcel.2005.09.003
15. T. Hattori, T. Isobe, K. Abe, H. Kikuchi, K. Kitagawa, T. Oda, C. Uchida, and M. Kitagawa Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 Cancer Res. 67 22 2007 10789 10795 10.1158/0008-5472.can-07-2033
16. X. Huang, X. Qian, C. Cheng, S. He, L. Sun, Q. Ke, L. Zhang, X. Pan, F. He, and Q. Wang Expression of Pirh2, a p27 Kip1 ubiquitin ligase, in hepatocellular carcinoma: correlation with p27 Kip1 and cell proliferation Hum. Pathol. 42 4 2011 507 515 10.1016/j.humpath.2010.04.021
17. N. Ishida, T. Hara, T. Kamura, M. Yoshida, K. Nakayama, and K.I. Nakayama Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export J. Biol. Chem. 277 17 2002 14355 14358 10.1074/jbc.c100762200
18. H. Jäkel, I. Peschel, C. Kunze, C. Weinl, and L. Hengst Regulation of p27Kip1 by mitogen-induced tyrosine phosphorylation Cell Cycle 11 10 2012 1910 1917 10.4161/cc.19957
19. H. Jäkel, C. Weinl, and L. Hengst Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control Oncogene 30 32 2011 3502 3512 10.1038/onc.2011.68
20. M.K. James, A. Ray, D. Leznova, and S.W. Blain Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity Mol. Cell. Biol. 28 1 2008 498 510 10.1128/mcb.02171-06
21. T. Kamura, T. Hara, M. Matsumoto, N. Ishida, F. Okumura, S. Hatakeyama, M. Yoshida, K. Nakayama, and K.I. Nakayama Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase Nat. Cell Biol. 6 12 2004 1229 1235 10.1038/ncb1194
22. S.K. Karnik, C.M. Hughes, X. Gu, O. Rozenblatt-Rosen, G.W. McLean, Y. Xiong, M. Meyerson, and S.K. Kim Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c Proc. Natl. Acad. Sci. U. S. A. 102 41 2005 14659 14664 10.1073/pnas.0503484102
23. V. Khattar, J. Fried, B. Xu, and J.V. Thottassery Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells Cancer Chemother. Pharmacol. 2014 1 10 10.1007/s00280-014-2666-7
24. S. Kotoshiba, T. Kamura, T. Hara, N. Ishida, and K.I. Nakayama Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase J. Biol. Chem. 280 18 2005 17694 17700 10.1074/jbc.m500866200
25. C. le Sage, R. Nagel, D.A. Egan, M. Schrier, E. Mesman, A. Mangiola, C. Anile, G. Maira, N. Mercatelli, S.A. Ciafre, M.G. Farace, and R. Agami Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation EMBO J. 26 15 2007 3699 3708 10.1038/sj.emboj.7601790
26. S.S. McAllister, M. Becker-Hapak, G. Pintucci, M. Pagano, and S.F. Dowdy Novel p27kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions Mol. Cell. Biol. 23 1 2003 216 228 10.1128/mcb.23.1.216-228.2003
27. D. Morishita, R. Katayama, K. Sekimizu, T. Tsuruo, and N. Fujita Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels Cancer Res. 68 13 2008 5076 5085 10.1158/0008-5472.can-08-0634
28. D. Muller, C. Bouchard, B. Rudolph, P. Steiner, I. Stuckmann, R. Saffrich, W. Ansorge, W. Huttner, and M. Eilers Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes Oncogene 15 21 1997 2561 2576 10.1038/sj.onc.1201440
29. M.J. Munoz-Alonso, J.C. Acosta, C. Richard, M.D. Delgado, J. Sedivy, and J. Leon p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells J. Biol. Chem. 280 18 2005 18120 18129 10.1074/jbc.m500758200
30. R.C. O'Hagan, M. Ohh, G. David, I.M. de Alboran, F.W. Alt, W.G. Kaelin Jr., and R.A. DePinho Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression Genes Dev. 14 17 2000 2185 2191 10.1101/gad.827200
31. I. Pérez-Roger, D. Solomon, A. Sewing, and H. Land Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27 (Kip1) binding to newly formed complexes Oncogene 14 20 1997 2373 2381 10.1038/sj.onc.1201197
32. J.A. Pietenpol, S.K. Bohlander, Y. Sato, N. Papadopoulos, B. Liu, C. Friedman, B.J. Trask, J.M. Roberts, K.W. Kinzler, J.D. Rowley, and et al. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias Cancer Res. 55 6 1995 1206 1210 http://www.ncbi.nlm.nih.gov/pubmed/7882309
33. P. Pineau, S. Volinia, K. McJunkin, A. Marchio, C. Battiston, B. Terris, V. Mazzaferro, S.W. Lowe, C.M. Croce, and Dejean A miR-221 overexpression contributes to liver tumorigenesis Proc. Natl. Acad. Sci. U. S. A. 107 1 2010 264 269 10.1073/pnas.0907904107
34. K. Polyak, J.Y. Kato, M.J. Solomon, C.J. Sherr, J. Massague, J.M. Roberts, and A. Koff p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest Genes Dev. 8 1 1994 9 22 10.1101/gad.8.1.9
35. A. Ray, M.K. James, S. Larochelle, R.P. Fisher, and S.W. Blain p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes Mol. Cell. Biol. 29 4 2009 986 999 10.1128/mcb.00898-08
36. A.A. Russo, P.D. Jeffrey, A.K. Patten, J. Massagué, and N.P. Pavletich Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex Nature 382 6589 1996 325 331 10.1038/382325a0
37. D. Santamaria, C. Barriere, A. Cerqueira, S. Hunt, C. Tardy, K. Newton, J.F. Caceres, P. Dubus, M. Malumbres, and M. Barbacid Cdk1 is sufficient to drive the mammalian cell cycle Nature 448 7155 2007 811 815 10.1038/nature06046
38. Kip1 EMBO J. 23 9 2004 1934 1942 10.1038/sj.emboj.7600198
39. R.J. Sheaff, M. Groudine, M. Gordon, J.M. Roberts, and B.E. Clurman Cyclin E-CDK2 is a regulator of p27Kip1 Genes Dev. 11 11 1997 1464 1478 10.1101/gad.11.11.1464
40. L.M. Tsvetkov, K.-H. Yeh, S.-J. Lee, H. Sun, and H. Zhang p27 Kip1 ubiquitination and degradation is regulated by the SCF Skp2 complex through phosphorylated Thr187 in p27 Curr. Biol. 9 12 1999 661 664 10.1016/s0960-9822(99)80290-5
41. Y. Wang, Y. Wang, J. Xiang, F. Ji, Y. Deng, C. Tang, S. Yang, Q. Xi, R. Liu, and W. Di Knockdown of CRM1 inhibits the nuclear export of p27(Kip1) phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer Cancer Lett. 343 1 2013 6 13 10.1016/j.canlet.2013.09.002
42. W. Yang, J. Shen, M. Wu, M. Arsura, M. FitzGerald, Z. Suldan, D.W. Kim, C.S. Hofmann, S. Pianetti, R. Romieu-Mourez, L.P. Freedman, and G.E. Soneshein Repression of transcription of the p 27 Kip 1 cyclin-dependent kinase inhibitor gene by c-Myc Oncogene 20 14 2001 1688 1702 10.1038/sj.onc.1204245