Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver

Free Radical Biology and Medicine

Volumn 47, Issue 3, 2009, Pages 219-228

  Gupte, Rakhee S ^a,b   Floyd, Beverly C ^b   Kozicky, Mark ^b   George, Shimran ^b   Ungvari, Zoltan I ^b   Neito, Vanessa ^b   Wolin, Michael S ^b   Gupte, Sachin A ^a,b  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Diabetes; Free radicals; Hydrogen peroxide; Liver; NADPH; NADPH oxidase; Oxidative stress; Src kinase; Superoxide anion; Zucker obese fa fa

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERGLYCEMIA; HYPERINSULINEMIA; LEAN BODY WEIGHT; LIVER HYPERTROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ZUCKER DIABETIC FATTY RAT;

6-AMINONICOTINAMIDE; ANIMALS; CELL EXTRACTS; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCONATES; GLUCOSEPHOSPHATE DEHYDROGENASE; GLYCOPROTEINS; LIVER; MALE; NADPH OXIDASE; OBESITY; PENTOSE PHOSPHATE PATHWAY; PERFUSION; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, ZUCKER; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; SUPEROXIDES; UP-REGULATION;

RATTUS;

EID: 67349123432     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.01.028     Document Type: Article

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