SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Journal of Cell Science

Volumn 129, Issue 11, 2016, Pages 2224-2238

  Kurkinen, Kaisa M A ^a   Marttinen, Mikael ^a   Turner, Laura ^b   Natunen, Teemu ^a   Mäkinen, Petra ^a   Haapalinna, Fanni ^c   Sarajärvi, Timo ^a   Gabbouj, Sami ^a   Kurki, Mitja ^c   Paananen, Jussi ^c   Koivisto, Anne M ^c   Rauramaa, Tuomas ^c   Leinonen, Ville ^c   Tanila, Heikki ^a   Soininen, Hilkka ^c   Lucas, Fiona R ^b   Haapasalo, Annakaisa ^a,c   Hiltunen, Mikko ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Amyloid ; BACE1; SEPT8

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; SEPTIN; SEPTIN 8; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; MESSENGER RNA; SECRETASE; SEPT8 PROTEIN, HUMAN; SEPT8 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NERVE CELL PLASTICITY; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TARGETING; TEMPORAL CORTEX; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DOWN REGULATION; GENE EXPRESSION PROFILING; GENETICS; HALF LIFE TIME; HEK293 CELL LINE; HIPPOCAMPUS; INTRACELLULAR SPACE; METABOLISM; NERVE CELL; PATHOLOGY; PROTEIN STABILITY; PROTEIN TRANSPORT; RNA INTERFERENCE; TEMPORAL LOBE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION PROFILING; HALF-LIFE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; INTRACELLULAR SPACE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; NEUROFIBRILLARY TANGLES; NEURONS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, MESSENGER; SEPTINS; TEMPORAL LOBE;

EID: 84976519101     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.185215     Document Type: Article

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