Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: A polygenic risk score approach

Journal of Alzheimer's Disease

Volumn 43, Issue 2, 2015, Pages 565-573

  Martiskainen, Henna ^a   Helisalmi, Seppo ^a   Viswanathan, Jayashree ^a   Kurki, Mitja ^a,b   Hall, Anette ^a   Herukka, Sanna Kaisa ^a   Sarajärvi, Timo ^a   Natunen, Teemu ^a   Kurkinen, Kaisa M A ^a   Huovinen, Jaakko ^a   Mäkinen, Petra ^a   Laitinen, Marjo ^a   Koivisto, Anne M ^a   Mattila, Kari M ^c   Lehtimäki, Terho ^c   Remes, Anne M ^a   Leinonen, Ville ^a,b   Haapasalo, Annakaisa ^a   Soininen, Hilkka ^a   Hiltunen, Mikko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Alzheimer's disease; amyloid peptide; biomarker; cerebrospinal fluid; polygenic risk score; risk gene; tau protein

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; BIOLOGICAL MARKER; GAMMA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; SECRETASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; EFFECT SIZE; ENZYME ACTIVITY; FEMALE; GENE LOCUS; GENETIC RISK; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; PATHOGENESIS; POLYGENIC RISK SCORE; RISK ASSESSMENT; TEMPORAL CORTEX; BRAIN; COHORT ANALYSIS; GENETIC ASSOCIATION; GENETIC SCREENING; GENETICS; GENOTYPE; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; APOLIPOPROTEINS E; BIOLOGICAL MARKERS; BRAIN; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC TESTING; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84911906938     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140777     Document Type: Article

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