Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

ChemMedChem

Volumn , Issue , 2016, Pages 1284-1295

  Prati, Federica ^a   Bergamini, Christian ^a   Fato, Romana ^a   Soukup, Ondrej ^b   Korabecny, Jan ^b   Andrisano, Vincenza ^a   Bartolini, Manuela ^a   Bolognesi, Maria Laura ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

Author keywords

Alzheimer s disease; antioxidants; chelation; cholinesterases; inhibitors; amyloid

Indexed keywords

5 CHLORO 7 (PIPERAZIN 1 YLMETHYL) 8 HYDROXYQUINOLINE; 5 CHLORO 7 [(4 (2 METHOXYBENZYL)PIPERAZIN 1 YL)METHYL]8 HYDROXYQUINOLINE; 5 CHLORO 7 [[4 (2 CHLOROBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 5 CHLORO 7 [[4 (3 METHOXYBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 5 CHLORO 7 [[4 (4 METHOXYBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 7 (PIPERAZIN 1 YLMETHYL) 8 HYDROXYQUINOLINE; 7 [(4 BENZYLPIPERAZIN 1 YL)METHYL] 8 HYDROXYQUINOLINE; 7 [(4 BENZYLPIPERAZIN 1 YL)METHYL]5 CHLORO 8 HYDROXYQUINOLINE; 7 [[(1 BENZYLPIPERIDIN 4 YL)AMINO]METHYL] 5 CHLORO 8 HYDROXYQUINOLINE; 7 [[4 (2 BROMOBENZYL)PIPERAZIN 1 YL]METHYL] 5 CHLORO 8 HYDROXYQUINOLINE; 7 [[4 (2 BROMOBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 7 [[4 (2 CHLOROBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 7 [[4 (2 METHOXYBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 7 [[4 (3 METHOXYBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 7 [[4 (4 METHOXYBENZYL)PIPERAZIN 1 YL]METHYL] 8 HYDROXYQUINOLINE; 8 QUINOLINOL DERIVATIVE; CHOLINESTERASE; CLIOQUINOL; CUPRIC ION; DONEPEZIL; GALANTAMINE; TACRINE; UNCLASSIFIED DRUG; ZINC ION;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL VIABILITY; CHELATION; CHOLINESTERASE INHIBITION; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; EQUILIBRIUM CONSTANT; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE PERMEABILITY; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTON TRANSPORT; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY;

EID: 84976512936     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201600014     Document Type: Article

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