Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 33, 2005, Pages 11840-11845

  Nguyen, Trent ^a   Hamby, Aaron ^a   Massa, Stephen M ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Polyglutamine; R6 2 transgenic mice; Small molecule therapeutics

Indexed keywords

CLIOQUINOL; HUNTINGTIN; MESSENGER RNA; METAL ION; MUTANT PROTEIN; POLYGLUTAMINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; EXON; GLUCOSE BLOOD LEVEL; HUNTINGTON CHOREA; IN VITRO STUDY; INSULIN BLOOD LEVEL; LIFESPAN; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WEIGHT REDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD GLUCOSE; BODY WEIGHT; CELL DEATH; CELL LINE; CLIOQUINOL; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; HUMANS; HUNTINGTON DISEASE; INSULIN; MALE; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PANCREAS; PEPTIDES; RATS; RNA, MESSENGER; SURVIVAL RATE;

MUS MUSCULUS;

EID: 23844482456     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502177102     Document Type: Article

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