Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

Archives of Toxicology

Volumn 91, Issue 3, 2017, Pages 1293-1307

  Chen, Si ^a   Zhang, Zhuhong ^a,b   Qing, Tao ^c   Ren, Zhen ^a   Yu, Dianke ^a   Couch, Letha ^a   Ning, Baitang ^a   Mei, Nan ^a   Shi, Leming ^c   Tolleson, William H ^a   Guo, Lei ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Liver toxicity; Nrf2 pathway; Oxidative stress; Usnic acid

Indexed keywords

GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR NRF2; USNIC ACID; BENZOFURAN DERIVATIVE; GLUTATHIONE; NFE2L2 PROTEIN, HUMAN;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA DAMAGE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; LIVER TOXICITY; LUCIFERASE ASSAY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; RNA SEQUENCE; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; UPREGULATION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM;

ANTIOXIDANT RESPONSE ELEMENTS; BENZOFURANS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUTATHIONE; HEP G2 CELLS; HUMANS; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; S PHASE CELL CYCLE CHECKPOINTS; SIGNAL TRANSDUCTION;

EID: 84976476407     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-016-1775-y     Document Type: Article

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