Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells

Chemico-Biological Interactions

Volumn 235, Issue , 2015, Pages 27-36

  Guo, Xiaoqing ^a   Chen, Si ^a   Zhang, Zhuhong ^a,b   Dobrovolsky, Vasily N ^a   Dial, Stacey L ^a   Guo, Lei ^a   Mei, Nan ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; MAPK pathway; Nitroxide; Reactive oxygen species; TEMPO

Indexed keywords

2,2,6,6 TETRAMETHYLPIPERIDINE 1 OXYL; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 7; DNA; FREE RADICAL; GLUTATHIONE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; SCAVENGER; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; AMINE OXIDE; BCL2L1 PROTEIN, MOUSE; MCL1 PROTEIN, MOUSE; PROTEIN BCL X; TEMPO;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CYCLIC N-OXIDES; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84927734582     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.04.009     Document Type: Article

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