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Volumn 142, Issue 1, 2014, Pages 33-44

The role of autophagy in usnic acid-induced toxicity in hepatic cells

Author keywords

Apoptosis; Autophagy; Liver toxicity; MAPK pathway; Usnic acid

Indexed keywords

3 METHYLADENINE; CASPASE 3; CASPASE 7; CHLOROQUINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P62; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; USNIC ACID; BENZOFURAN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

EID: 84927762227     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu154     Document Type: Article
Times cited : (47)

References (52)
  • 1
    • 0029961728 scopus 로고    scopus 로고
    • Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria
    • Abo-Khatwa, A. N., al-Robai, A. A. and al-Jawhari, D. A. (1996). Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria. Nat. Toxins 4, 96-102.
    • (1996) Nat. Toxins , vol.4 , pp. 96-102
    • Abo-Khatwa, A.N.1    al-Robai, A.A.2    al-Jawhari, D.A.3
  • 2
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
    • Alers, S., Loffler, A. S., Wesselborg, S. and Stork, B. (2012). Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Mol. Cell. Biol. 32, 2-11.
    • (2012) Mol. Cell. Biol , vol.32 , pp. 2-11
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 3
    • 80052028765 scopus 로고    scopus 로고
    • Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy
    • Apostolova, N., Gomez-Sucerquia, L. J., Gortat, A., Blas-Garcia, A. and Esplugues, J. V. (2011). Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy. Hepatology 54, 1009-1019.
    • (2011) Hepatology , vol.54 , pp. 1009-1019
    • Apostolova, N.1    Gomez-Sucerquia, L.J.2    Gortat, A.3    Blas-Garcia, A.4    Esplugues, J.V.5
  • 4
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke, E. H. (2005). Autophagy: Dual roles in life and death? Nat. Rev. Mol. Cell Biol. 6, 505-510.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 5
    • 15944398424 scopus 로고    scopus 로고
    • Accessed July 29, 2014
    • CFSAN (2001a). FDA Warns Consumers Not to Use the Dietary Supplement LipoKinetix. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm172824.htm. Accessed July 29, 2014.
    • (2001) FDA Warns Consumers Not to Use the Dietary Supplement LipoKinetix
  • 6
    • 0006218272 scopus 로고    scopus 로고
    • Accessed July 29, 2014
    • CFSAN (2001b). Letter to Distributor on Hazardous Dietary Supplement LipoKinetix. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm174455.htm. Accessed July 29, 2014.
    • (2001) Letter to Distributor on Hazardous Dietary Supplement LipoKinetix
  • 7
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang, L. and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 9
    • 84893356211 scopus 로고    scopus 로고
    • Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogenactivated protein kinase pathway
    • Chen, S., Xuan, J., Wan, L., Lin, H., Couch, L., Mei, N., Dobrovolsky, V. N. and Guo, L. (2014a). Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogenactivated protein kinase pathway. Toxicol. Sci. 137, 404-415.
    • (2014) Toxicol. Sci , vol.137 , pp. 404-415
    • Chen, S.1    Xuan, J.2    Wan, L.3    Lin, H.4    Couch, L.5    Mei, N.6    Dobrovolsky, V.N.7    Guo, L.8
  • 10
    • 84901922071 scopus 로고    scopus 로고
    • Sertraline induces endoplasmic reticulum stress in hepatic cells
    • Chen, S., Xuan, J., Couch, L., Iyer, A., Wu, Y., Li, Q. Z. and Guo, L. (2014b). Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology 322, 78-88.
    • (2014) Toxicology , vol.322 , pp. 78-88
    • Chen, S.1    Xuan, J.2    Couch, L.3    Iyer, A.4    Wu, Y.5    Li, Q.Z.6    Guo, L.7
  • 12
    • 22344444616 scopus 로고    scopus 로고
    • Does autophagy contribute to cell death?
    • Debnath, J., Baehrecke, E. H. and Kroemer, G. (2005). Does autophagy contribute to cell death? Autophagy 1, 66-74.
    • (2005) Autophagy , vol.1 , pp. 66-74
    • Debnath, J.1    Baehrecke, E.H.2    Kroemer, G.3
  • 16
    • 84862257733 scopus 로고    scopus 로고
    • The crosstalk between autophagy and apoptosis: Where does this lead?
    • Gordy, C. and He, Y.W. (2012). The crosstalk between autophagy and apoptosis: Where does this lead? Protein Cell 3, 17-27.
    • (2012) Protein Cell , vol.3 , pp. 17-27
    • Gordy, C.1    He, Y.W.2
  • 17
    • 79951922704 scopus 로고    scopus 로고
    • Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes
    • Guo, L., Dial, S., Shi, L., Branham, W., Liu, J., Fang, J. L., Green, B., Deng, H., Kaput, J. and Ning, B. (2011). Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes. Drug Metab. Dispos. 39, 528-538.
    • (2011) Drug Metab. Dispos , vol.39 , pp. 528-538
    • Guo, L.1    Dial, S.2    Shi, L.3    Branham, W.4    Liu, J.5    Fang, J.L.6    Green, B.7    Deng, H.8    Kaput, J.9    Ning, B.10
  • 19
    • 1242308775 scopus 로고    scopus 로고
    • Usnic acid-induced necrosis of cultured mouse hepatocytes: Inhibition of mitochondrial function and oxidative stress
    • Han, D., Matsumaru, K., Rettori, D. and Kaplowitz, N. (2004). Usnic acid-induced necrosis of cultured mouse hepatocytes: Inhibition of mitochondrial function and oxidative stress. Biochem. Pharmacol. 67, 439-451.
    • (2004) Biochem. Pharmacol , vol.67 , pp. 439-451
    • Han, D.1    Matsumaru, K.2    Rettori, D.3    Kaplowitz, N.4
  • 20
    • 84892698736 scopus 로고    scopus 로고
    • Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation
    • Hu, F., Han, J., Zhai, B., Ming, X., Zhuang, L., Liu, Y., Pan, S. and Liu, T. (2014). Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation. Apoptosis 19, 210-223.
    • (2014) Apoptosis , vol.19 , pp. 210-223
    • Hu, F.1    Han, J.2    Zhai, B.3    Ming, X.4    Zhuang, L.5    Liu, Y.6    Pan, S.7    Liu, T.8
  • 21
    • 84875270912 scopus 로고    scopus 로고
    • Protective effects of gomisin A isolated fromSchisandra chinensis against CCl(4)-induced hepatic and renal injury
    • Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Choi, Y. H., Kang, B. C., Hong, J. T. and Hwang, D. Y. (2013). Protective effects of gomisin A isolated fromSchisandra chinensis against CCl(4)-induced hepatic and renal injury. Int. J. Mol. Med. 31, 888-898.
    • (2013) Int. J. Mol. Med , vol.31 , pp. 888-898
    • Hwang, I.S.1    Kim, J.E.2    Lee, Y.J.3    Kwak, M.H.4    Choi, Y.H.5    Kang, B.C.6    Hong, J.T.7    Hwang, D.Y.8
  • 23
    • 84884360285 scopus 로고    scopus 로고
    • Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells
    • Kim, A., Yim, N. H. and Ma, J. Y. (2013a). Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells. BMC Complement. Altern. Med. 13, 233.
    • (2013) BMC Complement. Altern. Med , vol.13 , pp. 233
    • Kim, A.1    Yim, N.H.2    Ma, J.Y.3
  • 24
    • 84882658193 scopus 로고    scopus 로고
    • A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells
    • Kim, A. D., Kang, K. A., Kim, H. S., Kim, D. H., Choi, Y. H., Lee, S. J. and Hyun, J. W. (2013b). A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis. 4, e750.
    • (2013) Cell Death Dis , vol.4
    • Kim, A.D.1    Kang, K.A.2    Kim, H.S.3    Kim, D.H.4    Choi, Y.H.5    Lee, S.J.6    Hyun, J.W.7
  • 26
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu, M., Waguri, S., Koike, M., Sou, Y. S., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., et al. (2007). Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-1163.
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5    Hara, T.6    Mizushima, N.7    Iwata, J.8    Ezaki, J.9    Murata, S.10
  • 27
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer, G., Marino, G. and Levine, B. (2010). Autophagy and the integrated stress response. Mol. Cell 40, 280-293.
    • (2010) Mol. Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 28
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine, B. and Kroemer, G. (2008). Autophagy in the pathogenesis of disease. Cell 132, 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 29
    • 84861468623 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induced by sertraline, an antidepressant agent
    • Li, Y., Couch, L., Higuchi, M., Fang, J. L. and Guo, L. (2012). Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Toxicol. Sci. 127, 582-591.
    • (2012) Toxicol. Sci , vol.127 , pp. 582-591
    • Li, Y.1    Couch, L.2    Higuchi, M.3    Fang, J.L.4    Guo, L.5
  • 30
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T. and Thompson, C. B. (2005). Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 31
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., Yoshimori, T. and Levine, B. (2010). Methods in mammalian autophagy research. Cell 140, 313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 33
    • 9644272493 scopus 로고    scopus 로고
    • Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid
    • Neff, G. W., Reddy, K. R., Durazo, F. A., Meyer, D., Marrero, R. and Kaplowitz, N. (2004). Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J. Hepatol. 41, 1062-1064.
    • (2004) J. Hepatol , vol.41 , pp. 1062-1064
    • Neff, G.W.1    Reddy, K.R.2    Durazo, F.A.3    Meyer, D.4    Marrero, R.5    Kaplowitz, N.6
  • 34
    • 84879466547 scopus 로고    scopus 로고
    • Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis
    • Nepal, S. and Park, P. H. (2013). Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis. Biochim. Biophys. Acta 1833, 2111-2125.
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 2111-2125
    • Nepal, S.1    Park, P.H.2
  • 35
    • 84155194923 scopus 로고    scopus 로고
    • Activation of autophagy protects against acetaminophen-induced hepatotoxicity
    • Ni, H. M., Bockus, A., Boggess, N., Jaeschke, H. and Ding, W. X. (2012). Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 55, 222-232.
    • (2012) Hepatology , vol.55 , pp. 222-232
    • Ni, H.M.1    Bockus, A.2    Boggess, N.3    Jaeschke, H.4    Ding, W.X.5
  • 36
    • 40049097690 scopus 로고    scopus 로고
    • Systematic and simultaneous gene profiling of 84 drugmetabolizing genes in primary human hepatocytes
    • Ning, B., Dial, S., Sun, Y., Wang, J., Yang, J. and Guo, L. (2008). Systematic and simultaneous gene profiling of 84 drugmetabolizing genes in primary human hepatocytes. J. Biomol. Screen. 13, 194-201.
    • (2008) J. Biomol. Screen , vol.13 , pp. 194-201
    • Ning, B.1    Dial, S.2    Sun, Y.3    Wang, J.4    Yang, J.5    Guo, L.6
  • 37
    • 0842304860 scopus 로고    scopus 로고
    • Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria
    • Pramyothin, P., Janthasoot, W., Pongnimitprasert, N., Phrukudom, S. and Ruangrungsi, N. (2004). Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria. J. Ethnopharmacol. 90, 381-387.
    • (2004) J. Ethnopharmacol , vol.90 , pp. 381-387
    • Pramyothin, P.1    Janthasoot, W.2    Pongnimitprasert, N.3    Phrukudom, S.4    Ruangrungsi, N.5
  • 38
    • 84864303780 scopus 로고    scopus 로고
    • Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture
    • Sahu, S. C., Amankwa-Sakyi, M., O'Donnell, M. W., Jr and Sprando, R. L. (2012). Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture. J. Appl. Toxicol. 32, 722-730.
    • (2012) J. Appl. Toxicol , vol.32 , pp. 722-730
    • Sahu, S.C.1    Amankwa-Sakyi, M.2    O'Donnell, M.W.3    Sprando, R.L.4
  • 39
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen, P. O. and Gordon, P. B. (1982). 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 79, 1889-1892.
    • (1982) Proc. Natl. Acad. Sci. U.S.A , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 40
    • 84903215958 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes
    • Shi, Q., Greenhaw, J. and Salminen, W. F. (2014). Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. J. Appl. Toxicol., 34, 835-840.
    • (2014) J. Appl. Toxicol , vol.34 , pp. 835-840
    • Shi, Q.1    Greenhaw, J.2    Salminen, W.F.3
  • 41
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song, G., Ouyang, G. and Bao, S. (2005). The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 9, 59-71.
    • (2005) J. Cell. Mol. Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 42
    • 81155159789 scopus 로고    scopus 로고
    • Assessment of usnic acid toxicity in rat primary hepatocytes using (1)(3)C isotopomer distribution analysis of lactate, glutamate and glucose
    • Sonko, B. J., Schmitt, T. C., Guo, L., Shi, Q., Boros, L. G., Leakey, J. E. and Beger, R. D. (2011). Assessment of usnic acid toxicity in rat primary hepatocytes using (1)(3)C isotopomer distribution analysis of lactate, glutamate and glucose. Food Chem. Toxicol. 49, 2968-2974.
    • (2011) Food Chem. Toxicol , vol.49 , pp. 2968-2974
    • Sonko, B.J.1    Schmitt, T.C.2    Guo, L.3    Shi, Q.4    Boros, L.G.5    Leakey, J.E.6    Beger, R.D.7
  • 43
    • 84893692276 scopus 로고    scopus 로고
    • p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
    • Sui, X., Kong, N., Ye, L., Han, W., Zhou, J., Zhang, Q., He, C. and Pan, H. (2014). p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 28, 174-179.
    • (2014) Cancer Lett , vol.28 , pp. 174-179
    • Sui, X.1    Kong, N.2    Ye, L.3    Han, W.4    Zhou, J.5    Zhang, Q.6    He, C.7    Pan, H.8
  • 44
    • 80053372589 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells
    • Sun, T., Li, D.,Wang, L., Xia, L., Ma, J., Guan, Z., Feng, G. and Zhu, X. (2011). c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells. J. Transl. Med. 9, 161.
    • (2011) J. Transl. Med , vol.9 , pp. 161
    • Sun, T.1    Li, D.2    Wang, L.3    Xia, L.4    Ma, J.5    Guan, Z.6    Feng, G.7    Zhu, X.8
  • 46
    • 84983718691 scopus 로고    scopus 로고
    • Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells
    • Tai, W. T., Shiau, C. W., Chen, H. L., Liu, C. Y., Lin, C. S., Cheng, A. L., Chen, P. J. and Chen, K. F. (2013). Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis. 4, e485.
    • (2013) Cell Death Dis , vol.4
    • Tai, W.T.1    Shiau, C.W.2    Chen, H.L.3    Liu, C.Y.4    Lin, C.S.5    Cheng, A.L.6    Chen, P.J.7    Chen, K.F.8
  • 47
    • 0025046339 scopus 로고
    • Uncouplers of oxidative phosphorylation
    • Terada, H. (1990). Uncouplers of oxidative phosphorylation. Environ. Health Perspect. 87, 213-218.
    • (1990) Environ. Health Perspect , vol.87 , pp. 213-218
    • Terada, H.1
  • 48
    • 38049115875 scopus 로고    scopus 로고
    • Apoptosis and autophagy: Regulatory connections between two supposedly different processes
    • Thorburn, A. (2008). Apoptosis and autophagy: Regulatory connections between two supposedly different processes. Apoptosis 13, 1-9.
    • (2008) Apoptosis , vol.13 , pp. 1-9
    • Thorburn, A.1
  • 49
    • 84888035697 scopus 로고    scopus 로고
    • Inhibition of autophagy promotes CYP2E1-dependent toxicity inHepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK
    • Wu, D. and Cederbaum, A. I. (2013). Inhibition of autophagy promotes CYP2E1-dependent toxicity inHepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox Biol. 1, 552-565.
    • (2013) Redox Biol , vol.1 , pp. 552-565
    • Wu, D.1    Cederbaum, A.I.2
  • 50
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. and Greenberg, M. E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 51
    • 79955871965 scopus 로고    scopus 로고
    • Acute liver failure caused by 'fat burners' and dietary supplements: A case report and literature review
    • Yellapu, R. K., Mittal, V., Grewal, P., Fiel, M. and Schiano, T. (2011). Acute liver failure caused by 'fat burners' and dietary supplements: A case report and literature review. Can. J. Gastroenterol. 25, 157-160.
    • (2011) Can. J. Gastroenterol , vol.25 , pp. 157-160
    • Yellapu, R.K.1    Mittal, V.2    Grewal, P.3    Fiel, M.4    Schiano, T.5
  • 52
    • 83655190818 scopus 로고    scopus 로고
    • HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in humanmyeloid leukemia cells
    • Zhao, M., Yang, M., Yang, L., Yu, Y., Xie, M., Zhu, S., Kang, R., Tang, D., Jiang, Z., Yuan,W., et al. (2011). HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in humanmyeloid leukemia cells. BMB Rep. 44, 601-606.
    • (2011) BMB Rep , vol.44 , pp. 601-606
    • Zhao, M.1    Yang, M.2    Yang, L.3    Yu, Y.4    Xie, M.5    Zhu, S.6    Kang, R.7    Tang, D.8    Jiang, Z.9    Yuan, W.10


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