Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes

Journal of Applied Toxicology

Volumn 34, Issue 8, 2014, Pages 835-840

  Shi, Qiang ^a   Greenhaw, James ^a   Salminen, William F ^a,b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b PAREXEL INTERNATIONAL   (United States)

Author keywords

Cytochrome P450; Hepatocytes; Hepatotoxicity; Rat; Usnic acid

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA NAPHTHOFLAVONE; CYTOCHROME P450; KETOCONAZOLE; LACTATE DEHYDROGENASE; OXYGEN; PROADIFEN; TICLOPIDINE; USNIC ACID; ALPHA-NAPHTHOFLAVONE; BENZOFLAVONE DERIVATIVE; BENZOFURAN DERIVATIVE; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN ELECTRODE; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; METABOLISM; MITOCHONDRION; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BENZOFLAVONES; BENZOFURANS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY SUPPLEMENTS; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; HEPATOCYTES; KETOCONAZOLE; LIVER; MALE; MITOCHONDRIA; PROADIFEN; RATS; RATS, SPRAGUE-DAWLEY; TICLOPIDINE;

EID: 84903215958     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2892     Document Type: Article

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