Sertraline induces endoplasmic reticulum stress in hepatic cells

Toxicology

Volumn 322, Issue , 2014, Pages 78-88

  Chen, Si ^a   Xuan, Jiekun ^a   Couch, Letha ^a   Iyer, Advait ^a,b   Wu, Yuanfeng ^a   Li, Quan Zhen ^c   Guo, Lei ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Drug induced liver toxicity; Endoplasmic reticulum stress; MAPK pathway; Reporter gene assay; Sertraline

Indexed keywords

4 PHENYLBUTYRIC ACID; ALKALINE PHOSPHATASE; CHLORMETHINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LUCIFERASE; PROTEIN IRE1; SERTRALINE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENOME; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SIGNAL TRANSDUCTION;

APOPTOSIS; DRUG-INDUCED LIVER TOXICITY; ENDOPLASMIC RETICULUM STRESS; MAPK PATHWAY; REPORTER GENE ASSAY; SERTRALINE;

ALKALINE PHOSPHATASE; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL LINE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENETIC VECTORS; HEPATOCYTES; HUMANS; MICROARRAY ANALYSIS; POLYMERASE CHAIN REACTION; REAL-TIME POLYMERASE CHAIN REACTION; RNA SPLICING; RNA, MESSENGER; SEROTONIN UPTAKE INHIBITORS; SERTRALINE;

EID: 84901922071     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.05.007     Document Type: Article

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