Endoplasmic reticulum stress and store-operated calcium entry contribute to usnic acid-induced toxicity in hepatic cells

Toxicological Sciences

Volumn 146, Issue 1, 2015, Pages 116-126

  Chen, Si ^a   Zhang, Zhuhong ^a,b   Wu, Yuanfeng ^a   Shi, Qiang ^a   Yan, Hua ^b   Mei, Nan ^a   Tolleson, William H ^a   Guo, Lei ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ER stress; Liver toxicity; Store operated calcium entry; Usnic acid

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LUCIFERASE; STROMAL INTERACTION MOLECULE 1; USNIC ACID; X BOX BINDING PROTEIN 1; BENZOFURAN DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DAMAGE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME RELEASE; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; LUCIFERASE ASSAY; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN EXPRESSION; RAT; STORE OPERATED CALCIUM ENTRY; ENDOPLASMIC RETICULUM; METABOLISM; PHYSIOLOGICAL STRESS;

RATTUS;

BENZOFURANS; CALCIUM; ENDOPLASMIC RETICULUM; HEP G2 CELLS; HUMANS; STRESS, PHYSIOLOGICAL;

EID: 84936744503     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv075     Document Type: Article

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