Aloperine protects mice against ischemia-reperfusion (IR)-induced renal injury by regulating PI3K/AKT/mToR signaling and AP-1 activity

Molecular Medicine

Volumn 21, Issue , 2015, Pages 912-923

  Hu, Shuang ^a   Zhang, Yuxing ^a   Zhang, Meng ^a   Guo, Yanchao ^a   Yang, Ping ^a   Zhang, Shu ^a   Simsekyilmaz, Sakine ^a   Xu, Jun Fa ^b   Li, Jinxiu ^c   Xiang, Xudong ^c   Yu, Qilin ^a   Wang, Cong Yi ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALOPERINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN KINASE B; QUINOLIZIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA BINDING; ENZYME ACTIVITY; ENZYME REGULATION; GEL MOBILITY SHIFT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY INFILTRATE; KIDNEY FUNCTION; KIDNEY FUNCTION TEST; KIDNEY INJURY; KIDNEY TRANSPLANTATION; KIDNEY TUBULE DAMAGE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RENAL PROTECTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TUNEL ASSAY; WESTERN BLOTTING;

EID: 84975167728     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2015.00056     Document Type: Article

References (68)

1. Glaser DS. (1996) Acute renal failure. N. Engl. J. Med. 335:1321; author reply 1321-2.
2. Mangano CM, et al. (1998) Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group. Ann. Intern. Med. 128:194-203.
3. Aydin Z, van Zonneveld AJ, de Fijter JW, Rabelink TJ. (2007) New horizons in prevention and treatment of ischaemic injury to kidney transplants. Nephrol. Dial. Transplant. 22:342-6.
4. Drazen JM, Ingelfinger JR, Curfman GD. (2003) Expression of concern: Schiffl H, et Al. Daily hemodialysis and the outcome of acute renal failure. N. Engl. J. Med. 346:305-10. N. Engl. J. Med. 348:2137.
5. Kazmers A, Jacobs L, Perkins A. (1997) The impact of complications after vascular surgery in Veterans Affairs Medical Centers. J. Surg. Res. 67:62-6.
6. Chertow GM, et al. (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 16:3365-70.
7. Thurman JM, et al. (2006) Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/ reperfusion. J. Clin. Invest. 116:357-68.
8. Li L, et al. (2007) NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J. Immunol. 178:5899-911.
9. Kelly KJ, et al. (1996) Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J. Clin. Invest. 97:1056-63.
10. Day YJ, et al. (2005) Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. Am. J. Physiol. Renal Physiol. 288:F722-31.
11. Day YJ, et al. (2006) Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma. J. Immunol. 176:3108-14.
12. El Sabbahy M, Vaidya VS. (2011) Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdiscip. Rev. Syst. Biol. Med. 3:606-18.
13. Kusch A, et al. (2013) Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. Acta Physiol. (Oxf). 208:25-40.
14. Fan LH, et al. (2012) Effect of ischemia preconditioning on renal ischemia/reperfusion injury in rats. Int. Braz. J. Urol. 38:842-54.
15. Amura CR, et al. (2012) Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Mol. Immunol. 52:249-57.
16. Lu CY, Hartono J, Senitko M, Chen J. (2007) The inflammatory response to ischemic acute kidney injury: a result of the ‘right stuff’ in the ‘wrong place’? Curr. Opin. Nephrol. Hypertens. 16:83-9.
17. Thurman JM. (2007) Triggers of inflammation after renal ischemia/reperfusion. Clin. Immunol. 123:7-13.
18. Liang CJ, et al. (2014) Endothelial progenitor cells derived from Wharton’s jelly of human umbilical cord attenuate ischemic acute kidney injury by increasing vascularization and decreasing apoptosis, inflammation, and fibrosis. Cell Transplant. 24:1363-77.
19. Du T, Zhu YJ. (2014) The regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells. Mediators Inflamm. 2014:261697.
20. Thadhani R, Pascual M, Bonventre JV. (1996) Acute renal failure. N. Engl. J. Med. 334:1448-60.
21. Zhang CL, et al. (2012) Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats. Int. J. Biol. Sci. 8:363-74.
22. Chatterjee PK, et al. (2000) Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 58:658-73.
23. Bo CJ, et al. (2013) Effects of ischemic preconditioning in the late phase on homing of endothelial progenitor cells in renal ischemia/reperfusion injury. Transplant Proc. 45:511-6.
24. Li C, et al. (2011) Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-kappaB inactivation. J. Ethnopharmacol. 135:620-5.
25. Zhou Y, et al. (2010) Total alkaloids of Sophora alopecuroides increases the expression of CD4+ CD25+ Tregs and IL-10 in rats with experimental colitis. Am. J. Chin. Med. 38:265-77.
26. Lin Z, Huang CF, Liu XS, Jiang J. (2011) In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin. Pharmacol. Toxicol. 108:304-9.
27. Yuan XY, et al. (2010) Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur. J. Pharmacol. 629:147-52.
28. Zhou CC, et al. (1989) [Anti-inflammatory and anti-allergic action of aloperine]. [Article in Chinese]. Zhongguo Yao Li Xue Bao. 10:360-5.
29. Qavi HB, Wyde PR, Khan MA. (2002) In vitro Inhibition of HHV-6 replication by sophocarpines. Phytother. Res. 16:154-6.
30. Qiong-Xu Y, et al. (2014) Aloperine attenuated neuropathic pain induced by chronic constriction injury via anti-oxidation activity and suppression of the nuclear factor kappa B pathway. Biochem. Biophys. Res. Commun. 451:568-73.
31. Meldrum KK, et al. (2001) A novel model of ischemia in renal tubular cells which closely parallels in vivo injury. J. Surg. Res. 99:288-93.
32. Wang LT, et al. (2013) Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury. PLoS One. 8:e79814.
33. Li J, et al. (2011) Neutralization of the extracellular HMGB1 released by ischaemic damaged renal cells protects against renal ischaemia-reperfusion injury. Nephrol. Dial. Transplant. 26:469-78.
34. Zhong J, et al. (2014) MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis. J. Autoimmun. 53:95-104.
35. Zou R, et al. (2014) Telmisartan protects 5/6 Nx rats against renal injury by enhancing nNOS-derived NO generation via regulation of PPARgamma signaling. Am. J. Transl. Res. 6:517-27.
36. Zheng X, et al. (2006) Preventing renal ischemia-reperfusion injury using small interfering RNA by targeting complement 3 gene. Am. J. Transplant. 6:2099-108.
37. Yang J, et al. (2013) TJ0711, a novel vasodilatory beta-blocker, protects SHR rats against hypertension induced renal injury. Am. J. Transl. Res. 5:279-90.
38. Zhang S, et al. (2012) Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling. Am. J. Pathol. 181:937-46.
39. Pandey D, et al. (2011) SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases. Arterioscler. Thromb. Vasc. Biol. 31:1634-42.
40. Yang P, et al. (2013) Loss of Jak2 impairs endothelial function by attenuating Raf-1/ MEK1/Sp-1 signaling along with altered eNOS activities. Am. J. Pathol. 183:617-25.
41. Zhang S, et al. (2009) HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes. Int. J. Clin. Exp. Pathol. 3:24-38.
42. Sharfuddin AA, Molitoris BA. (2011) Pathophysiology of ischemic acute kidney injury. Nat. Rev. Nephrol. 7:189-200.
43. Devarajan P. (2006) Update on mechanisms of ischemic acute kidney injury. J. Am. Soc. Nephrol. 17:1503-20.
44. Kim J, et al. (2006) Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice. A role for manganese superoxide dismutase. J Biol. Chem. 281:20349-56.
45. Wang X, et al. (2009) c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2. Cell Res. 19:340-7.
46. Wang ZY, et al. (2005) Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J. Immunol. 174:2098-105.
47. Yu JH, Kim KH, Kim H. (2008) SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. Int. J. Biochem. Cell Biol. 40:677-88.
48. Schroder K, Tschopp J. (2010) The inflammasomes. Cell. 140:821-32.
49. Zhang J. (2007) Yin and yang interplay of IFN-gamma in inflammation and autoimmune disease. J. Clin. Invest. 117:871-3.
50. Iyer SS, Cheng G. (2012) Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit. Rev. Immunol. 32:23-63.
51. Kezic A, Becker JU, Thaiss F. (2013) The effect of mTOR-inhibition on NF-kappaB activity in kidney ischemia-reperfusion injury in mice. Transplant Proc. 45:1708-14.
52. Zhang J, et al. (2013) Administration of dexamethasone protects mice against ischemia/ reperfusion induced renal injury by suppressing PI3K/AKT signaling. Int. J. Clin. Exp. Pathol. 6:2366-75.
53. Chen J, et al. (2013) Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway. PLoS One. 8:e56224.
54. Hao W, et al. (2006) Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J. Biol. Chem. 281:3075-84.
55. Anitha M, et al. (2006) GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. J. Clin. Invest. 116:344-56.
56. Chen L, et al. (2013) SYK inhibition modulates distinct PI3K/AKT-dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell. 23:826-38.
57. Le Belle JE, et al. (2011) Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/ Akt-dependant manner. Cell Stem Cell. 8:59-71.
58. She QB, et al. (2005) The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/ Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell. 8:287-97.
59. Hemmings BA, Restuccia DF. (2012) PI3K-PKB/ Akt pathway. Cold Spring Harb. Perspect. Biol. 4:a011189.
60. Hirsch E, et al. (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 287:1049-53.
61. Weichhart T, Saemann MD. (2008) The PI3K/ Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis. 67 Suppl 3:iii70-4.
62. Doukas J, et al. (2006) Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc. Natl. Acad. Sci. U. S. A. 103:19866-71.
63. Ravingerova T, et al. (2012) PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt. Can. J. Physiol. Pharmacol. 90:1135-44.
64. Libermann TA, Baltimore D. (1990) Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell. Biol. 10:2327-34.
65. Liang HL, et al. (2009) Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis. 14:1176-89.
66. Zhang L, et al. (2014) Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells. Int. J. Mol. Med. 33:1613-20.
67. Rui T, Kvietys PR. (2005) NFkappaB and AP-1 differentially contribute to the induction of Mn-SOD and eNOS during the development of oxidant tolerance. FASEB J. 19:1908-10.
68. Gu J, et al. (2011) Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit. Care. 15:R153.