Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury

Acta Physiologica

Volumn 208, Issue 1, 2013, Pages 25-40

  Kusch, A ^a   Hoff, U ^a   Bubalo, G ^a   Zhu, Y ^a   Fechner, M ^a   Schmidt Ullrich, R ^b   Marko, L ^a,b   Muller D N ^a,b   Schmidt Ott, K M ^a,b   Gurgen D ^a   Blum, M ^b   Schunck, W H ^b   Dragun, D ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Eicosanoids; Ischaemia; Kidney reperfusion injury; NFK green B; PKC; Signal transduction; Sphingosine 1 P

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; 5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; ARACHIDONIC ACID; CHELERYTHRINE; CYCLOSPORIN A; CYTOCHROME P450; FENOFIBRATE; FINGOLIMOD; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLURANE; PARTHENOLIDE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C THETA; SOTRASTAURIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ACUTE KIDNEY FAILURE; AUTOIMMUNE DISEASE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TRANSPLANTATION; METABOLISM; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY; RETINA MACULA EDEMA; REVIEW;

ACUTE KIDNEY INJURY; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; EICOSANOIDS; HUMANS; KIDNEY; LYSOPHOSPHOLIPIDS; MOLECULAR TARGETED THERAPY; NF-KAPPA B; PROGNOSIS; PROTEIN KINASE C; RECEPTORS, LYSOSPHINGOLIPID; RENAL CIRCULATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84876306720     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12089     Document Type: Review

References (98)

1. Alberti, P., Bardella, L. & Comolli, R. 1993. Ribosomal protein S6 kinase and protein kinase C activation by epidermal growth factor after temporary renal ischemia. Nephron 64, 296-302.
2. Bajwa, A., Jo, S.K., Ye, H., Huang, L., Dondeti, K.R., Rosin, D.L., Haase, V.H., Macdonald, T.L., Lynch, K.R. & Okusa, M.D. 2010. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 21, 955-965.
3. Bajwa, A., Huang, L., Ye, H., Dondeti, K., Song, S., Rosin, D.L., Lynch, K.R., Lobo, P.I., Li, L. & Okusa, M.D. 2012. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 189, 2584-2596.
4. Bonventre, J.V. & Yang, L. 2011. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 121, 4210-4221.
5. Brinkmann, V., Cyster, J.G. & Hla, T. 2004. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 4, 1019-1025.
6. Campbell, W.B. & Falck, J.R. 2007. Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors. Hypertension 49, 590-596.
7. Campbell, W.B. & Fleming, I. 2010. Epoxyeicosatrienoic acids and endothelium-dependent responses. Pflugers Arch 459, 881-895.
8. Cao, C.C., Ding, X.Q., Ou, Z.L., Liu, C.F., Li, P., Wang, L. & Zhu, C.F. 2004. In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int 65, 834-845.
9. Capdevila, J.H., Falck, J.R. & Harris, R.C. 2000. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 41, 163-181.
10. Carroll, M.A. 2012. Role of the adenosine(2A) receptor-epoxyeicosatrienoic acid pathway in the development of salt-sensitive hypertension. Prostaglandins Other Lipid Mediat 98, 39-47.
11. Carroll, M.A., Balazy, M., Huang, D.D., Rybalova, S., Falck, J.R. & McGiff, J.C. 1997. Cytochrome P450-derived renal HETEs: storage and release. Kidney Int 51, 1696-1702.
12. Cheng, J., Ou, J.S., Singh, H., Falck, J.R., Narsimhaswamy, D., Pritchard, K.A. Jr. & Schwartzman, M.L. 2008. 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol 294, H1018-H1026.
13. Cheng, J., Wu, C.C., Gotlinger, K.H., Zhang, F., Falck, J.R., Narsimhaswamy, D. & Schwartzman, M.L. 2010. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. J Pharmacol Exp Ther 332, 57-65.
14. Chung, A.C. & Lan, H.Y. 2011. Chemokines in renal injury. J Am Soc Nephrol 22, 802-809.
15. Cosentino, F., Francia, P., Camici, G.G., Pelicci, P.G., Luscher, T.F. & Volpe, M. 2008. Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein. Arterioscler Thromb Vasc Biol 28, 622-628.
16. Cummins, E.P., Berra, E., Comerford, K.M., Ginouves, A., Fitzgerald, K.T., Seeballuck, F., Godson, C., Nielsen, J.E., Moynagh, P., Pouyssegur, J. & Taylor, C.T. 2006. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci USA 103, 18154-18159.
17. Delbridge, M.S., Shrestha, B.M., Raftery, A.T., El Nahas, A.M. & Haylor, J.L. 2007. Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine. Transplantation 84, 187-195.
18. Dolegowska, B., Blogowski, W. & Domanski, L. 2009. Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report. Transpl Int 22, 546-553.
19. Dragun, D., Bohler, T., Nieminen-Kelha, M., Waiser, J., Schneider, W., Haller, H., Luft, F.C., Budde, K. & Neumayer, H.H. 2004a. FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. Kidney Int 65, 1076-1083.
20. Dragun, D., Fritsche, L., Boehler, T., Peters, H., Budde, K. & Neumayer, H.H. 2004b. FTY720: early clinical experience. Transplant Proc 36, 544S-548S.
21. Egom, E.E., Mohamed, T.M., Mamas, M.A., Shi, Y., Liu, W., Chirico, D., Stringer, S.E., Ke, Y., Shaheen, M., Wang, T. et al. 2011. Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol 301, H1487-H1495.
22. Eldaif, S.M., Deneve, J.A., Wang, N.P., Jiang, R., Mosunjac, M., Mutrie, C.J., Guyton, R.A., Zhao, Z.Q. & Vinten-Johansen, J. 2010. Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation. Transpl Int 23, 217-226.
23. Elmarakby, A.A., Faulkner, J., Al-Shabrawey, M., Wang, M.H., Maddipati, K.R. & Imig, J.D. 2011. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Am J Physiol Regul Integr Comp Physiol 301, R1307-R1317.
24. Eltzschig, H.K. & Eckle, T. 2011. Ischemia and reperfusion-from mechanism to translation. Nat Med 17, 1391-1401.
25. Feng, X., Zhang, J., Barak, L.S., Meyer, T., Caron, M.G. & Hannun, Y.A. 1998. Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem 273, 10755-10762.
26. Feng, B., Chen, G., Zheng, X., Sun, H., Zhang, X., Zhang, Z.X., Xiang, Y., Ichim, T.E., Garcia, B., Luke, P., Jevnikar, A.M. & Min, W.P. 2009. Small interfering RNA targeting RelB protects against renal ischemia-reperfusion injury. Transplantation 87, 1283-1289.
27. Francescato, H.D., Costa, R.S., Scavone, C. & Coimbra, T.M. 2007. Parthenolide reduces cisplatin-induced renal damage. Toxicology 230, 64-75.
28. Freeley, M., Kelleher, D. & Long, A. 2011. Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites. Cell Signal 23, 753-762.
29. Friman, S., Arns, W., Nashan, B., Vincenti, F., Banas, B., Budde, K., Cibrik, D., Chan, L., Klempnauer, J., Mulgaonkar, S. et al. 2011. Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients. Am J Transplant 11, 1444-1455.
30. Fuller, T.F., Hoff, U., Kong, L., Naether, M., Wagner, P., Nieminen-Kelha, M., Nolting, J., Luft, F.C., Hegner, B. & Dragun, D. 2010. Cytoprotective actions of FTY720 modulate severe preservation reperfusion Injury in rat renal transplants. Transplantation 89, 402-408.
31. Fuller, T.F., Kusch, A., Chaykovska, L., Catar, R., Putzer, J., Haller, M., Troppmair, J., Hoff, U. & Dragun, D. 2012. Protein kinase C inhibition ameliorates posttransplantation preservation injury in rat renal transplants. Transplantation 94, 679-686.
32. Ghosh, S. & Hayden, M.S. 2012. Celebrating 25 years of NF-kappaB research. Immunol Rev 246, 5-13.
33. Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., Pinton, P., Rizzuto, R., Bernardi, P., Paolucci, F. & Pelicci, P.G. 2005. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233.
34. Gopalakrishnan, S., Hallett, M.A., Atkinson, S.J. & Marrs, J.A. 2007. aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion. Am J Physiol Cell Physiol 292, C1094-C1102.
35. Harper, M.T. & Poole, A.W. 2010. Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. J Thromb Haemost 8, 454-462.
36. Hemmings, D.G. 2006. Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. Naunyn Schmiedebergs Arch Pharmacol 373, 18-29.
37. Henke, N., Schmidt-Ullrich, R., Dechend, R., Park, J.K., Qadri, F., Wellner, M., Obst, M., Gross, V., Dietz, R., Luft, F.C., Scheidereit, C. & Muller, D.N. 2007. Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage. Circ Res 101, 268-276.
38. Hercule, H.C., Schunck, W.H., Gross, V., Seringer, J., Leung, F.P., Weldon, S.M., da Costa Goncalves, A., Huang, Y., Luft, F.C. & Gollasch, M. 2009. Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arterioscler Thromb Vasc Biol 29, 54-60.
39. Hla, T., Lee, M.J., Ancellin, N., Paik, J.H. & Kluk, M.J. 2001. Lysophospholipids-receptor revelations. Science 294, 1875-1878.
40. Hoff, U., Lukitsch, I., Chaykovska, L., Ladwig, M., Arnold, C., Manthati, V.L., Fuller, T.F., Schneider, W., Gollasch, M., Muller, D.N. et al. 2011. Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. Kidney Int 79, 57-65.
41. Hoitsma, A.J., Woodle, E.S., Abramowicz, D., Proot, P. & Vanrenterghem, Y. 2011. FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study. Nephrol Dial Transplant 26, 3802-3805.
42. Honetschlagerova, Z., Sporkova, A., Kopkan, L., Huskova, Z., Hwang, S.H., Hammock, B.D., Imig, J.D., Kramer, H.J., Kujal, P., Vernerova, Z., Chabova, V.C., Tesar, V. & Cervenka, L. 2011. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. J Hypertens 29, 1590-1601.
43. Imig, J.D., Zou, A.P., Stec, D.E., Harder, D.R., Falck, J.R. & Roman, R.J. 1996. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol 270, R217-R227.
44. Inoue, K., Sodhi, K., Puri, N., Gotlinger, K.H., Cao, J., Rezzani, R., Falck, J.R., Abraham, N.G. & Laniado-Schwartzman, M. 2009. Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. Am J Physiol Renal Physiol 297, F875-F884.
45. Ishii, I., Fukushima, N., Ye, X. & Chun, J. 2004. Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 73, 321-354.
46. Ishizuka, T., Cheng, J., Singh, H., Vitto, M.D., Manthati, V.L., Falck, J.R. & Laniado-Schwartzman, M. 2008. 20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther 324, 103-110.
47. Jang, H.R. & Rabb, H. 2009. The innate immune response in ischemic acute kidney injury. Clin Immunol 130, 41-50.
48. Jo, S.K., Bajwa, A., Awad, A.S., Lynch, K.R. & Okusa, M.D. 2008. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 73, 1220-1230.
49. Jo, S.K., Bajwa, A., Ye, H., Vergis, A.L., Awad, A.S., Kharel, Y., Lynch, K.R. & Okusa, M.D. 2009. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int 75, 167-175.
50. Joo, J.D., Kim, M., Horst, P., Kim, J., D'Agati, V.D., Emala, C.W. Sr & Lee, H.T. 2007. Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. Am J Physiol Renal Physiol 293, F1847-F1857.
51. Kappos, L., Antel, J., Comi, G., Montalban, X., O'Connor, P., Polman, C.H., Haas, T., Korn, A.A., Karlsson, G. & Radue, E.W. 2006. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med 355, 1124-1140.
52. Kappos, L., Radue, E.W., O'Connor, P., Polman, C., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L. & Burtin, P. 2010. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362, 387-401.
53. Karara, A., Dishman, E., Falck, J.R. & Capdevila, J.H. 1991. Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J Biol Chem 266, 7561-7569.
54. Kim, M., Kim, M., Park, S.W., Pitson, S.M. & Lee, H.T. 2010. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Am J Nephrol 31, 353-362.
55. Kim, M.G., Lee, S.Y., Ko, Y.S., Lee, H.Y., Jo, S.K., Cho, W.Y. & Kim, H.K. 2011. CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. Nephrol Dial Transplant 26, 111-124.
56. Kimura, T., Sato, K., Kuwabara, A., Tomura, H., Ishiwara, M., Kobayashi, I., Ui, M. & Okajima, F. 2001. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. J Biol Chem 276, 31780-31785.
57. Kinsey, G.R., Li, L. & Okusa, M.D. 2008. Inflammation in acute kidney injury. Nephron Exp Nephrol 109, e102-e107.
58. Kirby, R.J., Jin, Y., Fu, J., Cubillos, J., Swertfeger, D. & Arend, L.J. 2009. Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. Am J Physiol Renal Physiol 296, F634-F641.
59. Kovarik, J.M., Steiger, J.U., Grinyo, J.M., Rostaing, L., Arns, W., Dantal, J., Proot, P., Budde, K. & Sotrastaurin Renal Transplant Study Group. 2011. Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients. Transplantation 91, 317-322.
60. La Porta, C.A. & Comolli, R. 1993. Biochemical and immunological characterization of calcium-dependent and -independent PKC isoenzymes in renal ischemia. Biochem Biophys Res Commun 191, 1124-1130.
61. Lambert, I.H., Pedersen, S.F. & Poulsen, K.A. 2006. Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia. Acta Physiol (Oxf) 187, 75-85.
62. Lee, C.R., Imig, J.D., Edin, M.L., Foley, J., DeGraff, L.M., Bradbury, J.A., Graves, J.P., Lih, F.B., Clark, J., Myers, P. et al. 2010. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J 24, 3770-3781.
63. Lee, S.Y., Kim, D.H., Sung, S.A., Kim, M.G., Cho, W.Y., Kim, H.K. & Jo, S.K. 2011. Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. Nephrology (Carlton) 16, 163-173.
64. Lien, Y.H., Yong, K.C., Cho, C., Igarashi, S. & Lai, L.W. 2006. S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int 69, 1601-1608.
65. Liu, Y., Webb, H.K., Fukushima, H., Micheli, J., Markova, S., Olson, J.L. & Kroetz, D.L. 2012. Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor kappaB signaling. J Pharmacol Exp Ther 341, 725-734.
66. Loot, A.E., Popp, R., Fisslthaler, B., Vriens, J., Nilius, B. & Fleming, I. 2008. Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. Cardiovasc Res 80, 445-452.
67. Manhiani, M., Quigley, J.E., Knight, S.F., Tasoobshirazi, S., Moore, T., Brands, M.W., Hammock, B.D. & Imig, J.D. 2009. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol 297, F740-F748.
68. Matz, M., Naik, M., Mashreghi, M.F., Glander, P., Neumayer, H.H. & Budde, K. 2011. Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation. Expert Opin Drug Metab Toxicol 7, 103-113.
69. Matz, M., Lehnert, M., Lorkowski, C., Fabritius, K., Unterwalder, N., Doueiri, S., Weber, U.A., Mashreghi, M.F., Neumayer, H.H. & Budde, K. 2012. Effects of sotrastaurin, mycophenolic acid and everolimus on human B-lymphocyte function and activation. Transpl Int 25, 1106-1116.
70. McGiff, J.C. & Quilley, J. 1999. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol 277, R607-R623.
71. Meier, M., Menne, J., Park, J.K., Holtz, M., Gueler, F., Kirsch, T., Schiffer, M., Mengel, M., Lindschau, C., Leitges, M. & Haller, H. 2007. Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. J Am Soc Nephrol 18, 1190-1198.
72. Mochly-Rosen, D. & Gordon, A.S. 1998. Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12, 35-42.
73. Muller, D.N., Theuer, J., Shagdarsuren, E., Kaergel, E., Honeck, H., Park, J.K., Markovic, M., Barbosa-Sicard, E., Dechend, R., Wellner, M. et al. 2004. A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. Am J Pathol 164, 521-532.
74. Newton, A.C. 2010. Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab 298, E395-E402.
75. Nilakantan, V., Maenpaa, C., Jia, G., Roman, R.J. & Park, F. 2008. 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. Am J Physiol Renal Physiol 294, F562-F570.
76. Nithipatikom, K., DiCamelli, R.F., Kohler, S., Gumina, R.J., Falck, J.R., Campbell, W.B. & Gross, G.J. 2001. Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Anal Biochem 292, 115-124.
77. Node, K., Huo, Y., Ruan, X., Yang, B., Spiecker, M., Ley, K., Zeldin, D.C. & Liao, J.K. 1999. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285, 1276-1279.
78. Nowak, G., Bakajsova, D. & Samarel, A.M. 2011. Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Am J Physiol Renal Physiol 301, F197-F208.
79. Oliva, J.L., Griner, E.M. & Kazanietz, M.G. 2005. PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors 23, 245-252.
80. Padanilam, B.J. 2001. Induction and subcellular localization of protein kinase C isozymes following renal ischemia. Kidney Int 59, 1789-1797.
81. Panzer, U., Steinmetz, O.M., Turner, J.E., Meyer-Schwesinger, C., von Ruffer, C., Meyer, T.N., Zahner, G., Gomez-Guerrero, C., Schmid, R.M., Helmchen, U., Moeckel, G.W., Wolf, G., Stahl, R.A. & Thaiss, F. 2009. Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases. Am J Physiol Renal Physiol 297, F429-F439.
82. Park, S.W., Kim, M., D'Agati, V.D. & Lee, H.T. 2011. Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation. Kidney Int 80, 1315-1327.
83. Park, S.W., Kim, M., Brown, K.M., D'Agati, V.D. & Lee, H.T. 2012. Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 23, 266-280.
84. Polosukhina, D., Singaravelu, K. & Padanilam, B.J. 2003. Activation of protein kinase C isozymes protects LLCPK1 cells from H2O2 induced necrotic cell death. Am J Nephrol 23, 380-389.
85. Regner, K.R. & Roman, R.J. 2012. Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. Curr Opin Nephrol Hypertens 21, 33-38.
86. Regner, K.R., Zuk, A., Van Why, S.K., Shames, B.D., Ryan, R.P., Falck, J.R., Manthati, V.L., McMullen, M.E., Ledbetter, S.R. & Roman, R.J. 2009. Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. Kidney Int 75, 511-517.
87. Roman, R.J. 2002. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82, 131-185.
88. Salvadori, M., Budde, K., Charpentier, B., Klempnauer, J., Nashan, B., Pallardo, L.M., Eris, J., Schena, F.P., Eisenberger, U., Rostaing, L., Hmissi, A. & Aradhye, S. 2006. FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia. Am J Transplant 6, 2912-2921.
89. Sanz, A.B., Sanchez-Nino, M.D., Ramos, A.M., Moreno, J.A., Santamaria, B., Ruiz-Ortega, M., Egido, J. & Ortiz, A. 2010. NF-kappaB in renal inflammation. J Am Soc Nephrol 21, 1254-1262.
90. Slattery, C., Ryan, M.P. & McMorrow, T. 2008. Protein kinase C beta overexpression induces fibrotic effects in human proximal tubular epithelial cells. Int J Biochem Cell Biol 40, 2218-2229.
91. Steinberg, S.F. 2008. Structural basis of protein kinase C isoform function. Physiol Rev 88, 1341-1378.
92. Takuwa, Y., Okamoto, Y., Yoshioka, K. & Takuwa, N. 2012. Sphingosine-1-phosphate signaling in physiology and diseases. BioFactors 38, 329-337.
93. Vos, I.H., Govers, R., Grone, H.J., Kleij, L., Schurink, M., De Weger, R.A., Goldschmeding, R. & Rabelink, T.J. 2000. NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts. FASEB J 14, 815-822.
94. Wan, X., Fan, L., Hu, B., Yang, J., Li, X., Chen, X. & Cao, C. 2011. Small interfering RNA targeting IKKbeta prevents renal ischemia-reperfusion injury in rats. Am J Physiol Renal Physiol 300, F857-F863.
95. Wang, J.S., Singh, H., Zhang, F., Ishizuka, T., Deng, H., Kemp, R., Wolin, M.S., Hintze, T.H., Abraham, N.G., Nasjletti, A. & Laniado-Schwartzman, M. 2006. Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circ Res 98, 962-969.
96. Yang, B., Graham, L., Dikalov, S., Mason, R.P., Falck, J.R., Liao, J.K. & Zeldin, D.C. 2001. Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol 60, 310-320.
97. Yang, S., Lin, L., Chen, J.X., Lee, C.R., Seubert, J.M., Wang, Y., Wang, H., Chao, Z.R., Tao, D.D., Gong, J.P., Lu, Z.Y., Wang, D.W. & Zeldin, D.C. 2007. Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways. Am J Physiol Heart Circ Physiol 293, H142-H151.
98. Zhao, G., Tu, L., Li, X., Yang, S., Chen, C., Xu, X., Wang, P. & Wang, D.W. 2012. Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis. Hum Gene Ther 23, 688-699.