C-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2

Cell Research

Volumn 19, Issue 3, 2009, Pages 340-347

  Wang, Xiaoming ^a   Zhang, Yafeng ^a   Xiao, Gang ^a   Gao, Xiang ^b   Liu, Xiaolong ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Bcl 2; C Fos; Positive selection; Survival; Thymocyte development

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BCL 2; PROTEIN C FOS;

ANIMAL; ARTICLE; BINDING SITE; CELL SURVIVAL; CYTOLOGY; GENETIC SELECTION; GENETICS; METABOLISM; MOUSE; PROMOTER REGION; THYMUS; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; BINDING SITES; CELL SURVIVAL; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, ANTIGEN, T-CELL; SELECTION (GENETICS); THYMUS GLAND; UP-REGULATION;

MUS;

EID: 61849171872     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2008.322     Document Type: Article

References (25)

1. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol 2003; 21:137-176.
2. Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature 1999; 402:255-262.
3. Schlissel MS. Regulating antigen-receptor gene assembly. Nat Rev Immunol 2003; 3:890-899.
4. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1994; 1:197-205.
5. Williams O, Norton T, Halligey M, Kioussis D, Brady HJ. The action of Bax and Bcl-2 on T cell selection. J Exp Med 1998; 188:1125-1133.
6. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991; 67:879-888.
7. Chiu R, Boyle WJ, Meek J, et al. The c-fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 1988; 54:541-552.
8. 2+ signal. FEBS Lett 1988; 233:64- 68.
9. Jain J, Valge-Archer VE, Rao A. Analysis of the AP-1 sites in the IL2 promoter. J Immunol 1992; 148:1240-1250.
10. Nunomura S, Sato T, Habu S. Molecular basis for functional maturation of thymocytes: increase in c-fos translation with positive selection. J Immunol 2000; 164:5590-5595.
11. Rincon M, Flavell R. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol Cell Biol 1996; 160:1074-1084.
12. + thymocytes. J Biol Chem 1997; 272:8558-8566.
13. Wang ZQ, Ovitt C, Grigoriadis AE, et al. Bone and haematopoietic defects in mice lacking c-fos. Nature 1992; 360:741-745.
14. Liu X, Bosselut R. Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo. Nat Immunol 2004; 2:280-288.
15. Wang X, Xiao G, Zhang Y, et al. Regulation of Tcrb recombination ordering by c-Fos dependent RAG deposition. Nat Immunol 2008; 9:794-801.
16. Miyazaki T, Lemonnier FA. Modulation of thymic selection by expression of an immediate-early gene, early growth response l(Egr-l). J Exp Med 1998; 188:715-723.
17. Bettini M, Xi H, Milbrandt J, Kersh GJ. Thymocytes development in early growth reponse gene 1-deficient mice. J Immunol 2002; 169:1713-1720.
18. Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 1994; 367:281-284.
19. + thymocytes. Proc Natl Acad Sci USA 1999; 96:622-627.
20. von Boehmer H, Teh HS, Kisielow P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today 1989; 10:57-61.
21. Smeyne RJ, Vendrell M, Hayward M, et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature 1993; 363:166-169.
22. Preston GA, Lyon TT, Lang JE, et al. Induction of apoptosis by c-Fos protein. Mol Cell Biol 1996; 16:211-218.
23. Inada K, Okada S, Phuchareon J, et al. c-Fos induces apoptosis in germinal center B cells. J Immunol 1998; 161:3853-3861.
24. Zhang J, Zhang D, McQuade JS, et al. c-fos regulates neuronal excitability and survival. Nat Genet 2002; 30:416-420.
25. + thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J Exp Med 2003; 197:363-373.